Topical administration of Curcuma longa L. extract gel increases M2 macrophage polarization and collagen density in skin excision

Berbudi, Afiat; Anshori, Hendi; Andromeda, Andromeda; Kwarteng, Alexander; Putri, Almahitta Cintami; Atik, Nur

doi:10.7324/japs.2021.110111

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…The anti-inflammatory activity of turmeric was also evaluated: first, a gel of turmeric was applied to the wounds of mice. The gel induced an increase in ARG-1, which is a marker of M2 polarization, and a decrease in iNOS, which is a marker of M1 [131]. This same observation could be made on RAW264.7 cells [132].…”

Section: Curcuma Longa L 1753supporting

confidence: 71%

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Accipe,

Abadie,

Neviere

et al. 2023

Antioxidants

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Diabetic wound healing is a global medical challenge. Several studies showed that delayed healing in diabetic patients is multifactorial. Nevertheless, there is evidence that excessive production of ROS and impaired ROS detoxification in diabetes are the main cause of chronic wounds. Indeed, increased ROS promotes the expression and activity of metalloproteinase, resulting in a high proteolytic state in the wound with significant destruction of the extracellular matrix, which leads to a stop in the repair process. In addition, ROS accumulation increases NLRP3 inflammasome activation and macrophage hyperpolarization in the M1 pro-inflammatory phenotype. Oxidative stress increases the activation of NETosis. This leads to an elevated pro-inflammatory state in the wound and prevents the resolution of inflammation, an essential step for wound healing. The use of medicinal plants and natural compounds can improve diabetic wound healing by directly targeting oxidative stress and the transcription factor Nrf2 involved in the antioxidant response or the mechanisms impacted by the elevation of ROS such as NLRP3 inflammasome, the polarization of macrophages, and expression or activation of metalloproteinases. This study of the diabetic pro-healing activity of nine plants found in the Caribbean highlights, more particularly, the role of five polyphenolic compounds. At the end of this review, research perspectives are presented.

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Section: Curcuma Longa L 1753supporting

confidence: 71%

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Accipe,

Abadie,

Neviere

et al. 2023

Antioxidants

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“…Generally, the prophylactic activity of these compounds may be due to inhibited proliferation of plasmodial parasites as a result of direct cytotoxicity [62]. Curcumin is a flavonoid and its metabolites have immunomodulatory effects, including activation of TLR2, increased IL-10, production of parasite antibodies, and stimulation of macrophages (M2) in murine models [63][64][65]. Curcumin has also been demonstrated to inhibit histone acetylation and generate reactive oxygen species that can be cytotoxic to Plasmodium [26].…”

Section: Discussionmentioning

confidence: 99%

Piperine Enhances the Antimalarial Activity of Curcumin in Plasmodium berghei ANKA-Infected Mice: A Novel Approach for Malaria Prophylaxis

Khairani

Fauziah

Wiraswati

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Malaria is a prevalent vector-borne infectious disease in tropical regions, particularly in the absence of effective vaccines and because of the emergence resistance of Plasmodium to available antimalarial drugs. An alternative strategy for malaria eradication could be the combination of existing compounds that possess antimalarial activity to target multiple stages of the parasite. This study evaluated the antimalarial activity of a combination of curcumin and piperine in mice. A total of 42 mice were assigned to six groups depending on the treatment administered: group I (normal group) with aquadest; group II (negative control) with 0.2 ml DMSO; group III received a standard malarial drug (artesunate 5 mg/kg BW); groups IV, V, and VI with curcumin 300 mg/kg BW, curcumin 300 mg/kg BW and piperine 20 mg/kg BW, and piperine 20 mg/kg BW, respectively. The antimalarial activity was evaluated using prophylactic assays in Plasmodium berghei ANKA-infected mice, including the percentage parasitemia, clinical signs, survival rate, serum biochemical analysis, parasitic load in the liver, and liver histopathology. All treatments showed significant ( p < 0.05 ) antiplasmodial activity, with considerable parasite inhibition (>50%), curcumin 300 mg/kg BW (60.22%), curcumin 300 mg/kg BW, and piperine 20 mg/kg BW (77.94%) except for piperine 20 mg/kg BW (47.20%), eliciting greater inhibition relative to that of artesunate (51.18%). The delayed onset of clinical symptoms and prolonged survival rate were also significant ( p < 0.05 ) in the combination of curcumin and piperine treated group. In addition, the low parasitic load in the liver and mild histopathological changes in the liver suggest that the combination of curcumin and piperine had synergistic or additive effects. These findings demonstrate the promising use of these combined compounds as a malarial prophylactic. Further studies were recommended to assess their clinical usefulness.

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Topical administration of Curcuma longa L. extract gel increases M2 macrophage polarization and collagen density in skin excision

Cited by 2 publications

References 2 publications

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Antioxidant Activities of Natural Compounds from Caribbean Plants to Enhance Diabetic Wound Healing

Piperine Enhances the Antimalarial Activity of Curcumin in Plasmodium berghei ANKA-Infected Mice: A Novel Approach for Malaria Prophylaxis

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