Topical AHA in Dermatology: Formulations, Mechanisms of Action, Efficacy, and Future Perspectives

Abstract

The utilization of topical formulations containing alpha hydroxy acids (AHAs) has garnered considerable attention. This review summarizes the effectiveness of the most common topical AHA formulations, including mechanisms of action and future research directions. AHAs have a dramatic impact on diverse skin conditions, enhancing texture and stimulating collagen synthesis. Uncertainties persist regarding optimal concentration, pH, and vehicle for maximum efficacy. Advancements in formulation technologies offer opportunities for AHA penetration and stability. Understanding mechanisms is vital for skincare optimization. The review covers AHAs, their concentrations, formulation considerations, safety measures, and future directions.

Evaluating the Efficacy and Safety of Alpha-Hydroxy Acids in Dermatological Practice: A Comprehensive Clinical and Legal Review

“…This process not only improves skin texture and reduces fine lines but also enhances overall brightness and increases collagen production, thereby aiding in hydration and reducing hyperpigmentation. 6 However, the use of AHAs is not without disadvantages; they can increase skin’s sensitivity to sunlight, necessitating the consistent application of sunscreen, and can cause side effects like swelling, burning, and itching when used in higher concentrations for professional peels. 9 …”

“…These acids are available in different concentrations and formulations, making them suitable for a wide range of skin types and conditions. 5 , 6 …”