Topical Allopurinol or Corticosteroids and Acetylcysteine in the Early Treatment of Experimental Corneal Alkali Burns: A Pilot Study

Sekundo, Walter; Augustin, Albert J.; Strempel, I

doi:10.1177/112067210201200504

Cited by 20 publications

(16 citation statements)

References 15 publications

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“…9 In addition, topical NAC 8% eye drops have also been reported to improve the initial treatment of experimental alkali corneal burns. 22 In our study, better wound healing ratios and epithelialization ratios were obtained in the NAC group than in the control group, and the mean fibrosis score was significantly higher in the NAC group than in the control group.…”

Section: Discussionmentioning

confidence: 61%

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

Oğuz

Uslukaya

Alabalık

et al. 2015

International Surgery

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In this study, we aimed to compare the effects of dexpanthenol and N-acetylcysteine on wound healing. The wound healing process is a multifaceted sequence of activities associated with tissue restoration process. A number of investigations and clinical studies have been performed to determine new approaches for the improvement of wound healing. A total of 30 rats were divided into 3 equal groups. A linear 2-cm incision was made in the rats' skin. No treatment was administered in the first (control) group. Dexpanthenol cream was administered to the rats in the second group and 3% Nacetylcysteine cream was administered to the rats in the third group. The wound areas of all of the rats were measured on certain days. On the 21st day, all wounds were excised and histologically evaluated. The epithelialization and granulation rates between the groups were revealed to be similar in microscopic evaluations. Although the fibrosis was remarkable in the control group as compared with the other groups, it was similar in Nacetylcysteine and dexpanthenol groups. Angiogenesis rate was remarkable in the Nacetylcysteine group compared with the others. In multiple-comparison analysis, Dexpanthenol and N-acetylcysteine groups had similar results in terms of wound healing rates (P , 0.05), which were both higher than in the control group (P . 0.05). The efficacy of N-acetylcysteine in wound healing is comparable to dexpanthenol, and both substances can be used to improve wound healing.

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Section: Discussionmentioning

confidence: 61%

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

Oğuz

Uslukaya

Alabalık

et al. 2015

International Surgery

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“…Alkali, once applied onto eyes, is difficult to be completely rinsed away due to its rapid penetration into the anterior chamber and, therefore, an effective maneuver(s) is required to prevent alkali injury-induced CNV. Glucocorticoids are widely used for alkali injury of eyes with limited therapeutic benefits (59,60). In this study, we demonstrated that topical application of CX3CL1 markedly augmented the intraocular expression of antiangiogenic molecules, TSP-1 and ADAMTS-1, without affecting VEGF expression.…”

Section: Discussionmentioning

confidence: 62%

Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression

Kuno

et al. 2008

The Journal of Immunology

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Macrophage infiltration is observed during the course of corneal neovascularization. We examined corneal neovascularization process after alkali injury in mice deficient in fractalkine receptor/CX3CR1, which is expressed by macrophages. The mRNA expression of CX3CR1 and its ligand CX3CL1/fractalkine was augmented together in the corneas after alkali injury. Compared with WT mice, CX3CR1‐deficient (KO) mice exhibited enhanced corneal neovascularization 2 weeks after injury, as evidenced by enlarged CD31‐positive areas. Concomitantly, the infiltration of F4/80‐positive macrophages but not Gr‐1‐positive neutrophils was significantly attenuated in KO mice comparing with WT mice. The intraocular mRNA expression of angiogenic factor, vascular endothelial factor, was enhanced to similar extents in WT and KO after the injury. In contrast, the mRNA expression of anti‐angiogenic factors, a disintegrin and metalloprotease with thrombospondin (ADAMTS)‐1 and thrombospondin (TSP)‐1 was enhanced in wild‐type mice but the enhancement was attenuated in KO mice. A double immunofluorescence analysis demonstrated that F4/80‐positive cells also expressed CX3CR1 and ADAMTS‐1, TSP‐1 and ADAMTS‐1 were detected in CX3CR1‐positive cells. CX3CL1 enhanced the ADAMTS‐1 and TSP‐1 expression by peritoneal macrophages. Moreover, topical application of CX3CL1 inhibited corneal neovascularization at 2 weeks, together with enhanced intraocular ADAMTS‐1 and TSP‐1 expression. Thus, these observations indicate that intraocular infiltrating CX3CR1‐positive macrophages can dampen alkali‐induced corneal neovascularization by producing anti‐angiogenic factors, such as ADAMTS‐1 and TSPs.

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“…Topical 8% NAC eye drops also have been shown to be effective in the early treatment of experimental alkali corneal burns. 32 However, the potential benefits and action mechanisms of NAC administration are little documented in the high glucose-induced pathologic process of pHCECs, which mimics hyperglycemia-induced conjunctival complications.…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant N-Acetylcysteine Inhibits Inflammatory and Apoptotic Processes in Human Conjunctival Epithelial Cells in a High-Glucose Environment

Park

Kang

Kim

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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Topical Allopurinol or Corticosteroids and Acetylcysteine in the Early Treatment of Experimental Corneal Alkali Burns: A Pilot Study

Abstract: In the present study, topical allopurinol was as effective as established drugs, namely steroids and acetylcysteine, in the early treatment of experimental alkali corneal burns.

Cited by 20 publications

References 15 publications

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

Topical N-Acetylcysteine Improves Wound Healing Comparable to Dexpanthenol: An Experimental Study

Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression

The Antioxidant N-Acetylcysteine Inhibits Inflammatory and Apoptotic Processes in Human Conjunctival Epithelial Cells in a High-Glucose Environment

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