Topical and Transdermal Delivery with Chemical Enhancers and Nanoparticles

Skin-Permeable Nano-Lithocholic Lipidoid Efficiently Alleviates Psoriasis-like Chronic Skin Inflammations

“…23,24 However, their use is restricted due to local intolerance and difficulties in therapeutic feasibility. 25 In our previous studies, we developed skin-permeating liposomes that could deliver macromolecules such as peptides and nucleic acids across deeper dermal layers. 26,27 Taking cues from previous findings, in the present study, we designed and developed novel twin-chain conjugated lithocholic analogues LC6, LC8, LC10, and LC12 (Figure 1A) to reduce keratinocyte hyperproliferation and hyperimmune responses together by modulating EphA2 levels and activate the VDR to combat (Figure 1B).…”

“…Delivery of therapeutic molecules into deeper layers of the skin is the primary technical challenge due to lipophilic nature of the stratum corneum (SC) that limits the transport of therapeutic payloads into the deeper layers. , To overcome the limitation, skin permeation enhancers such as N-methyl-2-pyrrolidone (NMP) and azones were developed. , However, their use is restricted due to local intolerance and difficulties in therapeutic feasibility . In our previous studies, we developed skin-permeating liposomes that could deliver macromolecules such as peptides and nucleic acids across deeper dermal layers. , …”