Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Benson, Heather A. E.; Grice, Jeffrey E.; Mohammed, Yousuf; Namjoshi, Sarika; Roberts, Michael S.

doi:10.2174/1567201816666190201143457

Cited by 230 publications

(150 citation statements)

References 177 publications

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“…For enhancement, Several new approaches are involved in the application of electrical (Iontophoresis, sonophoresis, electroporation, and innovative methods such as magnetic energy and laser energy for commercial purposes) (Benson et al, 2019).…”

Section: Indirect Physical Methodsmentioning

confidence: 99%

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Transdermal drug delivery an emerging approach for antipsychotics

Tekawade

Nandgude

2020

ijrps

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Transdermal drug delivery system is one of the leading technology which gives extensive benefits compared to other dosage forms. In the case of drugs having a first-pass metabolism problem, small doses of drugs can be delivered. Oral drug delivery is associated with several problems like pain interrelated with the use of injections,needles, and the researchers mainly focus on the development of the transdermal route. The aim is to provide a rationale for improvement of the transdermal system of antipsychotics by highlighting the antipsychotic formulation and safely delivering medications across the skin.The present review emphasis on the latest advances in a transdermal delivery system which acts as a platform for effective transdermal delivery of antipsychotic. By using this technique, the pharmacotherapy of patients who have psychosis can be improved. There are numeral physical methods, and the skin penetration enhancement techniques have been developed that helps in delivering drugs through the skin.This technique helps to alter the barrier properties of skin and improves the penetration of the drug.It majorly highlights the possible role of microneedle in the transdermal system and acts as a different carrier in delivering several therapeutic agents effectively. This article summarizes thenovel transdermal delivery approaches, advantages, and the choice of antipsychotropic drugs.

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Section: Indirect Physical Methodsmentioning

confidence: 99%

“…By potential gradient, the charged drugs are passed from the skin and into the body. For the enhancement of a wide range of drugs, Iontophoresis has been widely studied (Benson et al, 2019). In September 2015 the security patch was introduced, but its sales were ceased in June 2016 as it showed burns at the application site.…”

Section: Iontophoresismentioning

confidence: 99%

Transdermal drug delivery an emerging approach for antipsychotics

Tekawade

Nandgude

2020

ijrps

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“…The ability to permeate through skin layers enhances the activity of invasomes, which exert their effects by fluidizing the bilayer structure of SC lipids and disturbing lipids and intracellular protein interactions [27]. Although there are comprehensive review literatures about topical dermal and transdermal drug delivery [28] and literatures about invasomes [29], this review deals with various aspects of invasomes with new organization and includes the latest studies about invasome.…”

Section: Introductionmentioning

confidence: 99%

Invasome: A Novel Nanocarrier for Transdermal Drug Delivery

Babaie

Bakhshayesh

et al. 2020

Nanomaterials

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Invasomes are novel vesicular systems that exhibit improved transdermal penetration compared to conventional liposomes. These vesicles contain phospholipids, ethanol, and terpene in their structures; these components confer suitable transdermal penetration properties to the soft vesicles. The main advantages of these nanovesicles lie in their ability to increase the permeability of the drug into the skin and decrease absorption into the systemic circulation, thus, limiting the activity of various drugs within the skin layer. In this paper, several features of invasomes, including their structure, mechanism of penetration, applications, characterization, and potential advantages in dermal drug delivery, are highlighted. Overall, this review suggests that enhanced transdermal penetration of drugs using invasomes provides an appropriate opportunity for the development of lipid vesicular carriers.

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“…In addition to enhancing drug bioavailability by helping to overcome the skin barrier, these nanosystems can enhance stability of the active compound, and aid in the formulation of poorly water-soluble (lipophilic) compounds. They may be further improved by incorporating penetration enhancers [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Compared to other nanovesicular systems, emulsions are simple to prepare and are effective in enhancing permeation into the skin by (i) providing a high solubilization capacity for both lipophilic and hydrophilic compounds, thereby increasing the loading capacity and dose application of the formulation; (ii) facilitating a large area of surface contact with the stratum corneum through their large surface area and good skin contact combined with their occlusive nature; (iii) having the possibility of direct permeation enhancement effect on the stratum corneum lipid structure due to their oil and surfactant content [ 12 ]. Such permeation enhancing components can be specifically chosen to maximize the response.…”

Section: Introductionmentioning

confidence: 99%

Development of an Oil-in-Water Self-Emulsifying Microemulsion for Cutaneous Delivery of Rose Bengal: Investigation of Anti-Melanoma Properties

et al. 2020

Self Cite

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The topical delivery route is proposed as an alternative or adjunctive approach to melanoma treatment, since the target site for melanoma treatment—the epidermal basal layer—is potentially accessible by this route. Microemulsion systems are effective delivery vehicles for enhanced, targeted skin delivery. This work investigated the effect of Rose Bengal (RB) and RB-loaded self-emulsifying microemulsions (SEMEs) on growth inhibition of human melanoma and normal skin cell monolayers, the safety of the excipients incorporated in SEMEs on human cell lines, and the in-vitro human skin penetration of RB delivered in SEMEs and control solution. Cellular toxicity was assessed by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and the growth inhibitory mechanism of RB was investigated by flow cytometry using PI staining. Unloaded SEMEs caused reduced cellular toxicity compared to the surfactant excipient, Labrasol®. RB-loaded SEMEs increased cell growth inhibition compared to the RB aqueous solution. Flow cytometry revealed apoptotic cells after treatment with RB-loaded SEMEs, indicating that apoptosis may be one of the mechanisms of cell death. Preliminary results of multiphoton microscopy with fluorescence lifetime imaging (MPM-FLIM) analysis showed deeper penetration with greater skin concentrations of RB delivered from SEMEs compared to the RB aqueous solution. This study highlights the enhanced skin penetration and antimelanoma effects of RB loaded in a SEME system.

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Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies

Cited by 230 publications

References 177 publications

Transdermal drug delivery an emerging approach for antipsychotics

Transdermal drug delivery an emerging approach for antipsychotics

Invasome: A Novel Nanocarrier for Transdermal Drug Delivery

Development of an Oil-in-Water Self-Emulsifying Microemulsion for Cutaneous Delivery of Rose Bengal: Investigation of Anti-Melanoma Properties

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