Topical and Transdermal Drug Delivery Systems

Gujarathi, Nayan A.; Abriata, Juliana Palma; Keservani, Raj K.; Sharma, Anil Kumar

doi:10.1201/9781003284017

Cited by 2 publications

(5 citation statements)

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“…In this approach, the drug is absorbed through the capillary blood vessels situated within dermis and subsequently distributed to the target site via systemic circulation. 147 TDDSs represent a valid alternative to oral and parenteral drug delivery methods, effectively mitigating and avoiding their inherent limitation. As a result, TDDSs have emerged as one of the most widely investigated routes for noninvasive drug delivery into the body.…”

Section: Transdermal Drug Delivery: Fundamentals and Applicationsmentioning

confidence: 99%

“…Additionally, the dermis encompasses lymphatic and capillary blood vessels, sensory nerve endings and appendages (hair follicles, sebaceous and sweat glands). 147,151 Notably, the capillaries within the dermis play a pivotal role in drug absorption, driven by the concentration gradient between the skin's surface and dermal layer. 151 The epidermis represents the outermost layer of the skin which is organized into two main parts: the viable epidermis, encompassing the stratum basale, stratum spinosum, and stratum granulosum, and nonviable epidermis, represented by the stratum corneum.…”

Section: Structure Of the Skinmentioning

confidence: 99%

“…150 Instead, the diffusion coefficient D depends on MW of the drug. 147 Based on these factors, the optimal candidate drug should have low molecular mass (high D) up to 600 Da, and moderately high partition coefficient K m in the range of 0.1-0.5. Other important drug characteristics to keep in account are the following: high potency (dose o 10 mg per day), and melting point o250 1C.…”

Section: Drug Absorption Via the Skinmentioning

confidence: 99%

“…These systems employ suitable equipment linked to TDDS for drug delivery and has different benefits, such as speedy and dependable drug delivery, amplified therapeutic efficacy of the administered medication, 148 and ease of transporting biomolecules and nanoparticles through the This journal is © The Royal Society of Chemistry 2024 stratum corneum. 147 Table 2 outlines the pros and cons of passive and active delivery systems.…”

Section: Transdermal Drug Delivery Systems In a Glimpsementioning

confidence: 99%

See 3 more Smart Citations

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Scattolin,

Tonon,

Botter

et al. 2024

J. Mater. Chem. B

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Section: Transdermal Drug Delivery: Fundamentals and Applicationsmentioning

confidence: 99%

Section: Structure Of the Skinmentioning

confidence: 99%

Section: Drug Absorption Via the Skinmentioning

confidence: 99%

Section: Transdermal Drug Delivery Systems In a Glimpsementioning

confidence: 99%

See 2 more Smart Citations

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Scattolin,

Tonon,

Botter

et al. 2024

J. Mater. Chem. B

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“…Згідно з рівнянням (3), яке було представлено фізіологом А. Фіком, швидкість дифузії може бути описана в контексті зазначених факторів [13]:…”

Section: вступunclassified

Assessment and Control of the Penetration of Drugs Into Biological Tissues Under the Influence of a Magnetic Field

Rohozhnikov,

Tereshchenko

2023

Bull. Kyiv Polytech. Inst. Ser. Instrum. Mak.

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The processes of assessment and control of the penetration of drugs into biological tissues under the influence of a magnetic field are investigated and systematically analysed.The aim of the work is to improve the methods for assessing magnetic field penetration and to develop new automated systems for optimising the penetration of drugs into tissues. The paper presents a mathematical model for estimating the depth of penetration of drugs into the biological environment and experimental studies of the influence of magnetic field parameters on the depth of penetration of drugs into biological tissues, followed by an analysis of the results. The features of the mathematical model of drug penetration through the cell membrane are considered in detail, and factorssuch as physical properties of the membrane, magnetic field parameters, temperature changes, and ion concentration are taken into account.The proposed model allows to effectively take into account the interaction of various factors with the value of magnetic induction. The influence of diffusion processes on the regulation of metabolism in cellular systems is highlighted and their role in the penetration of drugs through the skin is considered. A model describing the penetration of drugs into biological tissues through the parameters of magnetic induction is presented. It is noted that the study of the penetration of drugs into biological tissues is important for pharmaceutical research and the development of new methods of drug delivery.The model presented in this paper can serve as a powerful tool for optimising the parameters of magnetic therapy systems and improving the effectiveness of treatment. A methodology for studying the penetration of drugs and conducting experiments to assess and measure the depth of penetration is presented. The obtained research results can be used to further improve magnetic therapy methods and develop new treatment strategies.

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Topical and Transdermal Drug Delivery Systems

Cited by 2 publications

References 0 publications

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Synergistic applications of cyclodextrin-based systems and metal–organic frameworks in transdermal drug delivery for skin cancer therapy

Assessment and Control of the Penetration of Drugs Into Biological Tissues Under the Influence of a Magnetic Field

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