Topical Anti-Inflamatory Activity of Some Iridoids and Phenylpropanoids

Giner, Rosa M.; Sanz, M. J.; Ferrándiz, Marı́a Luisa; Recio, M. C.; Terencio, M. C.; Rı́os, José Luis

doi:10.1055/s-2006-960312

Cited by 8 publications

(6 citation statements)

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“…1). Some species of the genus Scrophularia are traditionally used in folk medicine, for example S. ningpoensis in Chinese medicine for treatment of inflammation (1), and some iridoids isolated from S. auriculata have shown anti-inflammatory activity (2).…”

Section: Introductionmentioning

confidence: 99%

Effects of Some Iridoids from Plant Origin on Arachidonic Acid Metabolism in Cellular Systems

Bermejo¹,

Lanza²,

Şen³

et al. 2000

Planta Med

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Seven iridoid glycosides isolated from different extracts of Scrophularia scorodonia L., namely bartsioside, aucubin, harpagide, harpagoside, 8-acetylharpagide, scorodioside and scropolioside B, had been evaluated for their in vitro anti-inflammatory activity in cellular systems generating COX and LOX metabolites. Structure-activity relationships obtained from in vitro screening results were discussed. Most compounds assayed did not exhibit any significant effect on PGE2- and LTC4-release from calcium ionophore-stimulated mouse peritoneal macrophages. In the LTC4-assay, only aucubin showed a significant effect, with an IC50 value of 72 microM. Harpagoside and harpagide also inhibited release of LTC4, but neither effect reached statistical significance. The release of PGE2 by mouse peritoneal macrophages stimulated with calcium ionophore was inhibited by harpagoside and 8-acetylharpagide, but this effect is not statistically significant. However, most iridoids assayed showed a significant effect on TXB2-release from calcium ionophorestimulated human platelets, with inhibition percentages slightly lower than the reference drug ibuprofen. Only harpagide, scorodioside and scropolioside B had no significant effect on TXB2-release. Our results indicate that selective inhibition of the TX-synthase enzyme may be the primary target of action of most of these iridoids, and one of the mechanisms through which they exert their anti-inflammatory effects.

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Section: Introductionmentioning

confidence: 99%

Effects of Some Iridoids from Plant Origin on Arachidonic Acid Metabolism in Cellular Systems

Bermejo¹,

Lanza²,

Şen³

et al. 2000

Planta Med

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“…Scrophularia auriculata, with the highest activity in the study of DTH, can be considered the most active species in the different models. In a previous study (Giner et al, 1991) we demonstrated the activity of this species on the acute TPA test, and isolated different iridoids as active principles.…”

Section: Discussionmentioning

confidence: 80%

Screening of antiinflammatory medicinal plants used in traditional medicine against skin diseases

Cuéllar¹,

Giner²,

Recio³

et al. 1998

Phytother. Res.

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The antiinflammatory activity of twelve medicinal plants used against skin disorders were tested in different experimental models of topical inflammation and one in vitro inhibitory test against phospholipase A 2 (PLA 2 ) from Naja naja venom. Forsythia suspensa was the most active species on the arachidonic acid (AA) topical test. This last species together with Astragalus membranaceus and Ranunculus sceleratus were the most active on the 12-O-tetradecanoylphorbol-13-acetate (TPA) acute ear oedema test. Scrophularia auriculata was the most active on multiple topical applications of TPA and on the oxazolone-induced delayed type hypersensitivity (DTH). Santolina chamaecyparissus was the only species that inhibited PLA 2 in vitro.

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“…Two catalpol derivates 12)], isolated from S. auriculata L., exert high antiinflammatory activity on mouse ear edema induced by tetradecanoylphorbol acetate (TPA). When these products were assayed at the same dose as indomethacin (0.5 mg/ear), they exhibited nearly the same effect as this reference drug with an edema percentage inhibition of 73.4% (Giner et al, 1991).…”

Section: Antiinflammationmentioning

confidence: 89%