Topical anti-inflammatory activity of quillaic acid from <i>Quillaja saponaria</i> Mol. and some derivatives

Rodríguez-Díaz, Maité; Delporte, Carla; Cartagena, Carlos; Cassels, Bruce K.; González, Patricia; Silva, Ximena; León, Fredy; Wessjohann, Ludger A.

doi:10.1111/j.2042-7158.2011.01263.x

Cited by 22 publications

(13 citation statements)

References 28 publications

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“…The relevance of the carboxyl group for a strong anti-inflammatory effect, particularly against TPA, has been reported [24]. It is worth noting that 3 and both anti-inflammatory drugs 4 and 5 have the acid group, and all showed a significant anti-inflammatory effect against TPA.…”

Section: Resultsmentioning

confidence: 99%

Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs

et al. 2015

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Abstract:The aim of the study was to assess changes in the activity of anti-inflammatory terpenes from Chilean medicinal plants after the formation of derivatives incorporating synthetic anti-inflammatory agents. Ten new hybrid molecules were synthesized combining terpenes (ferruginol (1), imbricatolic acid (2) and oleanolic acid (3)) with ibuprofen (4) or naproxen (5). The topical anti-inflammatory activity of the compounds was assessed in mice by the arachidonic acid (AA) and 12-O-tetradecanoyl phorbol 13-acetate (TPA) induced ear edema assays. Basal cytotoxicity was determined towards human lung fibroblasts, gastric epithelial cells and hepatocytes. At 1.4 µmol/mouse, a strong anti-inflammatory effect in the TPA assay was observed for oleanoyl ibuprofenate 12 (79.9%) and oleanoyl ibuprofenate methyl ester 15 (80.0%). In the AA assay, the best activity was observed for 12 at 3.2 µmol/mouse, with 56.8% reduction of inflammation, in the same range as nimesulide (48.9%). All the OPEN ACCESSMolecules 2015, 20 11220 terpenyl-synthetic anti-inflammatory hybrids showed better effects in the TPA assay, with best activity for 6, 12 and 15. The cytotoxicity of the compounds 8 and 10 with a free COOH, was higher than that of 2. The derivatives from 3 were less toxic than the triterpene. Several of the new compounds presented better anti-inflammatory effect and lower cytotoxicity than the parent terpenes.

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Section: Resultsmentioning

confidence: 99%

Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs

et al. 2015

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“…This leads to the prevention of the catalytic conversion of angiotensin I to angiotensin II that causes vasodilation 17 . Stylopine 18 and quillaic acid exhibits anti-inflammatory activity 19 . Cinobufagin, CBF, has antitumor activity as it is known to inhibit the growth of PC3 cells both in vitro and in vivo along with inducing apoptosis of tumor cells as per reports 20 .…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic study to discover natural molecules with activity against COVID-19

Singh

Flórez

2020

F1000Res

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Background: In 2020, the world has struggled to deal with coronavirus disease 2019 (COVID-19), which started in 2019 in China and has spread throughout the globe, affecting at least 31,175,835 humans globally and claiming 962,634 lives reported till 22nd September, 2020 by the World Health Organization. The main causative agent for this disease is known as severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). So far, there is no cure or proven therapeutics available till date. Therefore, we undertook this study to ﬁnd the most probable drug candidate through a bioinformatics study. Methods: Thus, we virtually screened the Zinc natural database using HTVS tool through molecular docking studies to analyze molecules recommended for the treatment of COVID-19. Results: Ramipril benzyl ester, propafenone dimer and Lariciresinol are three important drugs found from the present study due to their medicinal application which could be helpful in treating the disease. Stylopine, quillaic acid, cinobufagin, vitisinol C, segetalin A, scopolamine, 3-oxo glycyrrhetinic acid, conchinone B, lactimidomycin and cardinalins 4 are the other lead molecules that could be used as therapeutics against COVID-19 disease. Conclusions: The studied molecules could act as an effective inhibitory drug against COVID-19.

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“…Earlier topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives [19] has been reported. Antinociceptive activity of Quillaja saponaria Mol.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the anti-inflammatory activities of Quillaja saponaria Mol. saponin extract in mice

Sarkhel

2016

Toxicology Reports

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ObjectiveQuillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as antiinflammatory and analgesic agent in Chilean folk medicine.In the Present study the anti-inflammatory activities of the aqueous extract of commercially partially purified saponin from Quillaja saponaria Mol. in in vivo animal models.Methods & materials:Aqueous extract of the plant material was prepared by cold maceration. The anti-inflammatory activity of a commercial Quillaja saponaria Mol. (QS) saponin extract was investigated by carragenan induced mice paw edema model for acute inflammation (Winter, 1962) [16].ResultsThe anti-inflammatory activity was evaluated by carragenan in paw edema model in swiss albino mice (18–20 g). The anti-inflammatory activity was found to be dose dependent in carragenan induced paw edema. QS was found to significantly (p < 0.05) reduce the carragenan induced mice paw edema (38.59%; 20 mg/kg bw) as compared to carragenan control. The percentage inhibition of standard anti-inflammatory drug indomethacin was (55%; 10 mg/kg, bw).ConclusionThe results of the present study demonstrate that the aqueous extract of Quillaja saponaria saponins (QS) possess significant anti-inflammatory activity.

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Topical anti-inflammatory activity of quillaic acid from Quillaja saponaria Mol. and some derivatives

Abstract: The structural modifications performed and the biological results suggest that the aldehyde and carboxyl groups are relevant to the anti-inflammatory activity in these models.

Cited by 22 publications

References 28 publications

Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs

Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs

Bioinformatic study to discover natural molecules with activity against COVID-19

Evaluation of the anti-inflammatory activities of Quillaja saponaria Mol. saponin extract in mice

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