Topical anti-inflammatory activity of Serjania erecta Radlk (Sapindaceae) extracts

Gomig, Franciane; Pietrovski, Evelise Fernandes; Guedes, Alessandro; Dalmarco, Eduardo Monguilhott; Calderari, Mirele Titton; Guimarães, Cláudio L.; Pinheiro, Rafael Mota; Cabrini, Daniela Almeida; Otuki, Michel Fleith

doi:10.1016/j.jep.2008.03.017

Cited by 30 publications

(30 citation statements)

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“…Neste estudo, foram avaliados os efeitos de três extratos de plantas medicinais que possuem alguma indicação de uso popular para distúrbios do trato gastrointestinal, a Persea major (Nees) Kopp, a Piper mollicomum Kunth e a Serjania erecta Radlk (Peckolt & Peckolt, 1888;Cosmo et al, 2007;Gomig et al, 2008). Apesar das indicações de uso, não há descrição na literatura de estudos que validem a ação destas plantas sobre a motilidade gastrointestinal.…”

Section: Discussionunclassified

“…e Serjania erecta Radlk. (Peckolt & Peckolt, 1888;Cosmo et al, 2007;Gomig et al, 2008). A Serjania erecta (Sapindaceae) é comumente conhecida como "cinco-folhas", "cipó-cinco-folhas" ou "retrato de teiú" e alguns estudos com diferentes espécies de Serjania e os compostos isolados demonstraram atividades analgésica, antiinflamatória tópica, antibacteriana, antifúngica e gastroprotetora (di Stasi et al, 1988;Ekabo et al, 1996;de Lima et al, 2006;Gomig et al, 2008;Castelo et al, 2009).…”

Section: Introductionunclassified

“…A Serjania erecta (Sapindaceae) é comumente conhecida como "cinco-folhas", "cipó-cinco-folhas" ou "retrato de teiú" e alguns estudos com diferentes espécies de Serjania e os compostos isolados demonstraram atividades analgésica, antiinflamatória tópica, antibacteriana, antifúngica e gastroprotetora (di Stasi et al, 1988;Ekabo et al, 1996;de Lima et al, 2006;Gomig et al, 2008;Castelo et al, 2009). As análises fitoquímicas do extrato hidroalcoólico de caules e folhas da S. erecta mostraram a presença de saponinas, flavonóides, triterpenóides, esteróides, taninos, catequinas, cumarinas e quinonas (Gomig et al, 2008). O "pau de Andrade" ou "abacateiro do mato", nomes populares da Persea major (Lauraceae), apresentou atividade analgésica, anti-edematogênica e gastroprotetora em estudos anteriores (Assis et al, 2003a;Assis et al, 2003b;Cosmo et al, 2007).…”

Section: Introductionunclassified

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Ação de extratos de plantas medicinais sobre a motilidade do trato gastrointestinal

Potrich

Baggio

Freitas

et al. 2014

Rev. bras. plantas med.

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Palavras-chave: plantas medicinais, distúrbios gastrointestinais, esvaziamento gástrico, trânsito intestinalABSTRACT: Action of medicinal plant extracts on the gastrointestinal tract motility. Many plants are popularly used for the treatment and healing of diseases. The Persea major Kopp, Piper mollicomum Kunth. and Serjania erecta Radlk. are used in several illnesses, including the treatment of disorders of the gastrointestinal tract. The aim of this study was to evaluate the effects of the extracts of these plants on the gastrointestinal motility. Swiss mice were orally treated with extracts one hour before the administration of a semisolid solution of 1.5% carboxymethylcellulose and 0.05% phenol red. After 15 minutes, the gastric emptying and intestinal transit were determined. The hydroalcoholic extract of P. major (100 to 1000 mg Kg -1 , p.o.) and the hydroalcoholic extract of P. mollicomum (100 and 300 mg Kg -1 , p.o.) increased the intestinal transit. However, only the P. major extract (100 and 300 mg Kg -1 ) increased the gastric emptying. The ethanolic extract of S. erecta (100 to 1000 mg Kg -1 , p.o.) did not alter the gastrointestinal motility. These results suggest that Persea major and Piper mollicomum can be of interest for further studies in the search of active principles or effective plant material for the treatment of disorders of the gastrointestinal tract, such as constipation. INTRODUÇÃOA utilização de plantas no tratamento de enfermidades é relatada como sendo uma das práticas mais antigas da humanidade (Calixto, 2001). E por isso, acredita-se que as plantas medicinais foram testadas e homologadas através do seu uso prolongado, considerando-as eficazes e seguras, sem efeitos colaterais (Lapa et al., 2000). Neste contexto, são de extrema importância o estudo e a validação do uso de plantas medicinais que apresentem indicações populares.

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Section: Discussionunclassified

Section: Introductionunclassified

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Ação de extratos de plantas medicinais sobre a motilidade do trato gastrointestinal

Potrich

Baggio

Freitas

et al. 2014

Rev. bras. plantas med.

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“…4 Qualitative phytochemical analysis of the hydroalcoholic extract obtained from stem and leaves of S. erecta showed the presence of saponins, flavonoids, triterpenoids, steroids, tannins, and catechins. 5 Pharmacological evaluation of S. erecta showed topical anti-inflammatory activity in mice. 5 The aim of the present study is to evaluate the gastroprotective action of two preparations of crude extracts from S. erecta leaves.…”

Section: Introductionmentioning

confidence: 99%

“…5 Pharmacological evaluation of S. erecta showed topical anti-inflammatory activity in mice. 5 The aim of the present study is to evaluate the gastroprotective action of two preparations of crude extracts from S. erecta leaves.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effect ofSerjania erectaRadlk (Sapindaceae): Involvement of Sensory Neurons, Endogenous Nonprotein Sulfhydryls, and Nitric Oxide

Arruda

Coelho

Honda

et al. 2009

Journal of Medicinal Food

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The present study reveals the pharmacological action of Serjania erecta Radlk. (Family Sapindaceae), an important medicinal plant species used in the Brazilian Pantanal against gastric pain. The methanolic (Me) and chloroformic (Se) extracts obtained from leaves of S. erecta were challenged by a very strong necrotizing agent in rodents, absolute ethanol. Se was also confronted with a nitric oxide synthase inhibitor (N G -nitro-l-arginine methyl ester), a capsaicin cation channel transient receptor potential vanilloid type 1 antagonist (ruthenium red), or a sulfhydryl-blocker (N-ethylmaleimide) to evaluate the participation of these cytoprotective factors in gastroprotection. In an in vivo experimental model, Me and Se presented several degrees of gastroprotective action without signs of acute toxicity. The best gastroprotective effect was restricted to all doses of Se. The mechanisms involving the gastroprotective action of Se are related to an augmented defense mechanism of the gastrointestinal mucosa consisting of sensory neurons, nitric oxide, and sulfhydryl groups that prevent and attenuate the ulcer process. The presence of polyisoprenoids in the Se explains the potent gastroprotective action of this medicinal species. Effective gastroprotective action and the absence of acute toxicity indicate this species may be a promising herbal drug against gastric disease.

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In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula

et al. 2011

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Ethanol extracts of Senna villosa, Serjania yucatanensis, Byrsonima bucidaefolia, and Bourreria pulchra were evaluated for their in vitro activity against epimastigotes and trypomastigotes of Trypanosoma cruzi. Results showed that the leaf extracts of S. yucatanensis and B. pulchra were the most active against epimastigotes (IC(100) = 100 μg/mL) and trypomastigotes of T. cruzi (95% or more reduction in the number of parasites at 100 and 50 μg/mL). However, only the leaf extract of S. yucatanensis showed significant trypanocidal activity when tested in vivo, reducing 75% of the parasitemia in infected mice at 100 mg/kg. This same extract inhibited the egress of trypomastigotes from infected cells and proved not to be cytotoxic (IC(50) = 318.8 ± 2.3 μg/mL).

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Topical anti-inflammatory activity of Serjania erecta Radlk (Sapindaceae) extracts

Cited by 30 publications

References 17 publications

Ação de extratos de plantas medicinais sobre a motilidade do trato gastrointestinal

Ação de extratos de plantas medicinais sobre a motilidade do trato gastrointestinal

Gastroprotective Effect ofSerjania erectaRadlk (Sapindaceae): Involvement of Sensory Neurons, Endogenous Nonprotein Sulfhydryls, and Nitric Oxide

In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula

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