Topical Antiglaucoma Medications and Lacrimal Drainage System Obstruction

Kashkouli, Mohsen Bahmani; Rezaee, Reza; Nilforoushan, N; Salimi, Saeedeh; Foroutan, Ali; Naseripour, Masood

doi:10.1097/iop.0b013e3181706829

Cited by 44 publications

(32 citation statements)

References 10 publications

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“…Preoperative subclinical inflammation induced by previous exposure to long-term topical ocular glaucoma medication was felt to be the cause of this inflammation and higher surgical failure rate. Punctal stenosis is not uncommon from chronic exposure to topical ocular medication [40, 41]. In the NR, there are numerous cases of unilateral punctual stenosis occurring only on the side of the patient's monocular glaucoma.…”

Section: Hypothesis 5: Long-term Topical Ocular Medications With Tmentioning

confidence: 99%

The Role of Medications in Causing Dry Eye

Fraunfelder

Sciubba²,

Mathers

2012

Journal of Ophthalmology

108

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The purpose of this paper is to review the possible role of polypharmacy in causing dry eye disease (DED), reflecting the complex interactions and complications associated with the use of multiple systemic and topical ocular medications. The pharmacological, physiological, anatomical, and histological mechanisms causing dry mouth differ little from those causing dry eye. Oral polypharmacy is the most common cause of dry mouth, but has not been investigated as a cause of dry eye. Topical ocular polypharmacy has been shown to cause DED. Information on drugs that likely cause or aggravate DED and the controversial role of preservatives in topical ocular medications are examined. Systemic or topical ocular medications and preservatives used in topical ocular drugs may cause dry eye through the drug's therapeutic action, ocular surface effects, or preservatives, and the effects probably are additive. Long-term use of topical ocular medications, especially those containing preservatives such as BAK, may play an important role in DED and the role of polypharmacy needs further study. We review possible ways to decrease the risk of medication-related dry eye.

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Section: Hypothesis 5: Long-term Topical Ocular Medications With Tmentioning

confidence: 99%

The Role of Medications in Causing Dry Eye

Fraunfelder

Sciubba²,

Mathers

2012

Journal of Ophthalmology

108

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“…In another investigation, Guzek et al 12 assessed strength and weakness of lacrimal tests including FDDT in patients with partial NLDO and claimed that an abnormal FDDT essentially confirms obstructive epiphora. 13 Kashkouli et al 8 studied on topical antiglaucoma medications associated with lacrimal drainage obstruction in adults with mean age of almost 60 years and reported that sensitivity and specificity of 5-minute FDDT were 92% and 82.7%, respectively. Similar to this study, Bowyer et al 13 also found that sensitivity and negative predictive value of FDDT in patients with congenital NLDO decreases but specificity and positive predictive value increases in time.…”

Section: Discussionmentioning

confidence: 99%

“…8 To the best of the authors' knowledge, there is no study evaluating FDDT sensitivity and specificity in adults with NLDO, which was the first aim of this study. The authors previously found a 92% sensitivity and 82.7% specificity for 5-minute FDDT in lacrimal drainage system obstruction associated with topical antiglaucoma medications.…”

mentioning

confidence: 97%

Reliability of Fluorescein Dye Disappearance Test in Assessment of Adults With Nasolacrimal Duct Obstruction

Kashkouli¹,

Mirzajani²,

Jamshidian-Tehrani³

et al. 2013

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…Docetaxel has been reported to cause epiphora due to canalicular stenosis 66. The mechanisms of drug-induced lacrimal drainage obstruction may be related to the medications themselves, preservatives or duration of topical treatment 64. This condition has been proposed to be either dose-related or idiosyncratic 19.…”

Section: Canalicular Stenosismentioning

confidence: 99%

Assessment and management of proximal and incomplete symptomatic obstruction of the lacrimal drainage system

Kashkouli

Pakdel

Kiavash

2012

Middle East Afr J Ophthalmol

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Epiphora is a common complaint of patients who present to an Ophthalmology Clinic. In many cases, epiphora is due to an obstruction in the lacrimal drainage system. However, a subgroup of symptomatic patients with epiphora has a patent lacrimal drainage system. Such cases are usually termed ‘functional obstruction’ and / or ‘stenosis of the lacrimal drainage system’. Various etiologies and diagnostic and therapeutic approaches have been described in literature, which implies the lack of a standardized approach. This article will review the evolving diagnostic and therapeutic approaches in literature, and in the end, propose a paradigm in approaching this group of patients.

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Topical Antiglaucoma Medications and Lacrimal Drainage System Obstruction

Abstract: Patients taking a combination of topical antiglaucoma medications showed significantly increased risk of developing lacrimal drainage system obstruction. Both total and upper obstruction was significantly more frequent in patients on topical antiglaucoma medications.

Cited by 44 publications

References 10 publications

The Role of Medications in Causing Dry Eye

The Role of Medications in Causing Dry Eye

Reliability of Fluorescein Dye Disappearance Test in Assessment of Adults With Nasolacrimal Duct Obstruction

Assessment and management of proximal and incomplete symptomatic obstruction of the lacrimal drainage system

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