Topical Antimicrobial Microparticle-Based Polymeric Materials for Burn Wound Infection

doi:10.26538/tjnpr/v5i10.1

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…However, it should be used with caution due to its cytotoxicity to cells and tissues compared to classic ionic compounds ( 27 , 34 , 38 ) . The absorption of silver at the cellular level with a potential cytotoxic effect and the antimicrobial resistance of pathogens colonized in the wound bed as a result of prolonged use ( 39 , 40 ) reinforce the need to control and ration the use of silver for a period of no more than four weeks ( 41 ) .…”

Section: Discussionmentioning

confidence: 99%

Nanocomposites used in the treatment of skin lesions: a scoping review

Deus,

Lima,

Negreiros

et al. 2024

Rev. esc. enferm. USP

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Objective: To map the nanocomposites used in the treatment of skin lesions. Method: A scoping review, according to the Joanna Briggs Institute methodology, carried out on eight databases, a list of references and Google Scholar to answer the question: “Which nanocomposites are used as a cover for the treatment of skin lesions?”. Two independent reviewers selected the final sample using inclusion/exclusion criteria using the EndNote® and Rayyan programs. Data was extracted using an adapted form and reported using the PRISMA checklist extension, and the protocol was registered in the Open Science Framework (OSF). Results: 21 articles were selected, with nanofibers, nanogels and nanomembranes as the nanocomposites described in wound healing, alone or in association with other therapies: negative pressure and elastic. Silver nanomaterials stand out in accelerating healing due to their antimicrobial and anti-inflammatory action, but caution should be exercised due to the risk of cytotoxicity and microbial resistance. Conclusion: Nanocomposites used in wound treatment are effective in accelerating healing and reducing costs, and the addition of bioactives to nanomaterials has added extra properties that contribute to healing.

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Section: Discussionmentioning

confidence: 99%

Nanocomposites used in the treatment of skin lesions: a scoping review

Deus,

Lima,

Negreiros

et al. 2024

Rev. esc. enferm. USP

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“…Contudo a sua utilização deve ser cautelosa, em virtude da citotoxicidade às células e tecidos em uso dos compostos iônicos clássicos (27,34,38) . A absorção da prata a nível celular com potencial efeito citotóxico e resistência antimicrobiana de patógenos colonizados no leito da ferida decorrente do uso prolongado (39,40) reforçam a necessidade de controle e racionamento na utilização da prata por um período não superior a quatro semanas (41) .…”

Section: Discussionunclassified

Nanocompostos utilizados no tratamento de lesões cutâneas: revisão de escopo

Deus,

Lima,

Negreiros

et al. 2024

Rev. esc. enferm. USP

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RESUMO Objetivo: Mapear os nanocompostos utilizados no tratamento de lesões cutâneas. Método: Revisão de escopo, conforme metodologia Joanna Briggs Institute, realizada em oito bases de dados, lista de referências e Google Scholar para responder à pergunta: “Quais os nanocompostos utilizados como cobertura para o tratamento de lesões cutâneas?”. Dois revisores independentes, selecionaram a amostra final mediante critérios de inclusão/exclusão usando os programas EndNote® e Rayyan. Os dados foram extraídos com formulário adaptado e reportados pela extensão do checklist PRISMA, o protocolo foi registrado na Open Science Framework (OSF). Resultados: 21 artigos selecionados, trouxeram nanofibras, nanogéis e nanomembranas como os nanocompostos descritos na cicatrização de feridas, isolados ou em associação a outras terapias: pressão negativa e elástica. Os nanomateriais com prata destacam-se em acelerar a cicatrização pela ação antimicrobiana e anti-inflamatória, recomenda-se cautela no uso pelo risco de citotoxicidade e resistência microbiana. Conclusão: Os nanocompostos utilizados no tratamento de feridas são eficientes em acelerar a cicatrização e reduzir custos, a adição de bioativos aos nanomateriais agregaram propriedades extras que contribuem com a cicatrização.

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“…Similar to liposomes, niosomes are multilamellar vesicular structure 3,4 containing nonionic surfactants that can entrap together hydrophilic and hydrophobic, antigens and hormonal drugs. 5,6 Niosome can be prepared by using various types of non-ionic surfactants to form a vesicle to entrap the active drugs in it. [7][8][9] The drug was loaded to the vesicle at a minimum concentration to produce fewer side effects and stability and modified the release pattern.…”

Section: Introductionmentioning

confidence: 99%

Mupirocin Loaded Niosomal Gel for Topical Wound Healing Applications

2023

TJNPR

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Mupirocin-loaded niosomal gel has been developed to enhance the drug deposition for a longer period at the targeted site and sustained the rate of release of the drug. A lipid hydration technique was employed to formulate niosome with polymers Carbopol and Chitosan at various concentrations. Tween 80 is a non-ionic surfactant utilized in the formulation to improve the entrapment efficiency of the drug. Cholesterol is utilized in the formulation to improve vesicle stability and glycerin is a gelling and moistening agent. In addition, to improve the stability of the niosomal gel Methylparaben is also added to the formulation.FTIR and DSC studies are used to find out the compatibility study of the drug and other excipients. The post-evaluation studies confirm that yield percentage lies between 85 -93%, entrapment efficiency 83 -97%, drug content lies within the limit of 87 -98%, pH range matches the skin pH and the obtained range is 6.25 -7.3. Viscosity and Spreadability show the result within the limit of 410 -560 cps and 3.8 -5.4 g cm/s respectively. The post-evaluation study was further subjected to an in-vitro diffusion study. The formulation F5 has shown a better sustained release of active drug (98% at 12hr) which contains a higher ratio of carbopol and tween 80. A higher concentration of tween 80 increases the entrapment efficiency of mupirocin in the niosome and carbopol helps to sustain the release rate to an optimum period as a swellable gelling agent.

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Topical Antimicrobial Microparticle-Based Polymeric Materials for Burn Wound Infection

Cited by 3 publications

References 32 publications

Nanocomposites used in the treatment of skin lesions: a scoping review

Nanocomposites used in the treatment of skin lesions: a scoping review

Nanocompostos utilizados no tratamento de lesões cutâneas: revisão de escopo

Mupirocin Loaded Niosomal Gel for Topical Wound Healing Applications

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