Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice

Kang, Jong Soon; Youm, Jong-Kyung; Jeong, Se Kyoo; Park, Byeong Deog; Yoon, Won Kee; Han, Mi Kyung; Lee, Hyunju; Han, Sang‐Bae; Lee, Kiho; Park, Song‐Kyu; Lee, Seung Hun; Yang, Kailun; Moon, Eun‐Yi; Kim, Hwan Mook

doi:10.1016/j.intimp.2007.08.009

Cited by 20 publications

(17 citation statements)

References 32 publications

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“…Adhesion molecules, such as VCAM-1 and ICAM-1, are also known to be involved in the infiltration of leukocytes into sites of inflammation. It was demonstrated that VCAM-1 and ICAM-1 contribute to the accumulation of mast cells and neutrophils in dust mite extract-induced AD mice (Kang et al, 2007). These adhesion molecules are induced by the proinflammatory cytokine TNF-␣ at sites of inflammation (Ackermann and Harvima, 1998;de Vries et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice

Sung

Yoon

Jang

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice

Sung

Yoon

Jang

et al. 2011

Journal of Ethnopharmacology

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“…The skin barrier function is commonly measured by the TEWL value which is a marker for the inside-outside barrier. It can be measured by different devices including Tewameter® (Courage + Khazaka, Cologne, Germany) [14,112], VapoMeter (Delfin, Kuopio, Finland) [16], Evaporimeter® (Asahi Biomed, Yokohama, Japan) [15], Meeco® Water Analyzer (Meeco, Warrington, PA, USA), or other similar devices [116]. …”

Section: Effect Of Oral Phytocer-based Dietary Supplements On Skin Bamentioning

confidence: 99%

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

Tessema

Gebre‐Mariam

Neubert

et al. 2017

Skin Pharmacol Physiol

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The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the skin barrier function have been investigated. Recently, however, the barrier function improving effect of plant-derived CERs has attracted much attention. Phyto-derived CERs (phytoCERs) are preferable due to their assumed higher safety as they are mostly isolated from dietary sources. The beneficial effects of phytoCER-based oral dietary supplements for skin hydration and skin barrier reinforcement have been indicated in several studies involving animal models as well as human subjects. Ingestible dietary supplements containing phytoCERs are also widely available on the market. Nonetheless, little effort has been made to investigate the potential cosmetic applications of topically administered phytoCERs. Therefore, summarizing the foregoing investigations and identifying the gap in the scientific data on plant-derived CERs intended for skin-health benefits are of paramount importance. In this review, an attempt is made to synthesize the information available in the literature regarding the effects of phytoCER-based oral dietary supplements on skin hydration and barrier function with the underlying mechanisms.

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“…* P<0.05 is the significance level compared to Wt mice. in addition, neutrophil infiltration, which indicates the presence of the inflammatory response, was detected indirectly by quantifying the neutrophil-specific MPO enzyme activity in the ear tissue, since neutrophils kill engulfed infectious pathogens by using mPo to catalyze the reaction of hydrogen peroxide with chloride ions to produce the microbicidal hypochlorite ion (18)(19)(20). the mPo activity increased in the Pa treatment group except in the 1% Pa-treated group, while it was unchanged in the aoo-treated group as expected ( fig.…”

Section: Role Of Gata3 In the Induction Of Allergic Skin Inflammationmentioning

confidence: 99%

GATA binding protein 3 overexpression and suppression significantly contribute to the regulation of allergic skin inflammation

Bae

Lee²,

Shim³

et al. 2011

Int J Mol Med

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Abstract. Gata binding protein 3 (Gata3) is a key molecule regulating the balance in the ratio of type 1 helper t (th1) cells to type 2 helper t (th2) cells, which is thought to be indicative of the pathogenesis of allergic diseases such as asthma and atopic dermatitis. the aim of this study was to investigate the role of GATA3 in allergic skin inflammation. transgenic (tg) mice overexpressing human Gata3 (hGata3) were produced by the microinjection of pCMV/hGATA3 constructs into fertilized mouse eggs. the hGata3 gene was successfully expressed at the protein level in the lymph node and thymus of cmV/hGata3 transfected cells and tg mice. CMV/hGATA3 Tg mice showed a significant increase in the allergic skin inflammation response such as ear thickness, draining auricular lymph node (aln) weight, epidermal thickness, inflammatory cell number and Th2 immunoglobulin (Ig) concentration compared to wild-type (Wt) mice after phthalic anhydride (Pa) treatment. furthermore, the secretion of th2 type cytokines was increased by Pa treatment in cmV/ hGata3 tg mice, while the secretion of th1 type cytokine was suppressed under the same conditions. However, the increased levels of th2 type cytokines in cmV/hGata3 tg mice were almost recovered by the down-regulation of Gata3 expression with D-pinitol treatment. Therefore, these findings suggest that Gata3 could be considered as a potential target regulating the mechanism responsible for the differences in allergic skin inflammation. Introductionallergic diseases, such as asthma, rhinitis and atopic dermatitis, are characterized by inflammation driven by type 2 helper T (th2) cells (1). in allergic individuals, the exposure to allergens results in activation of antigen-specific type 2 helper (Th2) cells and secretion of a variety of cytokines and inflammatory mediators that provoke the inflammatory response (2).th2 cytokines are predominantly regulated by the Gata binding protein 3 (Gata3). the zinc-finger transcription factor Gata3 is the master regulator of th2 cell differentiation and is strongly up-regulated during th2 differentiation (3). Generally, th1 and th2 cells are differentiated from common t precursor cells in the t cell developmental process (4,5). Two polarized subsets can be identified on the basis of the class of cytokines which secreted from each cell. th1 cells mainly secrete il-2 and ifn-γ, while th2 cells secrete il-4, il-5, il-6, il-10 and il-13 (6). Gata3 is believed to function by causing chromatin remodeling of the th2 cytokine locus by binding at multiple promoter sites and thus allowing th2 cells to express il-4, il-5 and il-13 (7,8). furthermore, several studies using Gata-3 deletion mutants have suggested that the Gata3 protein plays an important role in vertebrate development and th2 differentiation (9,10). in addition, transgenic (tg) mice that overexpress Gata3 spontaneously have asthma-like symptoms. in these mice, the number of Gata3-positive cells is increased in the asthmatic lung and in allergic rhinitis, while these cells are found to furthe...

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Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice

Cited by 20 publications

References 32 publications

Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice

Topical application of Rehmannia glutinosa extract inhibits mite allergen-induced atopic dermatitis in NC/Nga mice

Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function

GATA binding protein 3 overexpression and suppression significantly contribute to the regulation of allergic skin inflammation

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