Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation

Wilgus, Traci A.; Ross, Mary S.; Parrett, Michelle L.; Oberyszyn, Tatiana M.

doi:10.1016/s0090-6980(00)00089-7

Cited by 123 publications

(114 citation statements)

References 62 publications

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“…Firstly, we demonstrated that COX-2 and TGF Beta-1 showed similar cellular profiles as both were expressed mainly by the infiltrating inflammatory cells in the wound area, this was in line with other studies [52][53][54][55], however, we endorsed our finding by showing for the first time actual colocalization of Cox-2 and TGF Beta-1 on the cellular level in the wound area. Secondarily, demonstrating that both mediators showed a similar pattern of expression in the wound, where COX-2 upregulation and downregulation was associated with a concomitant similar change in TGF Beta-1, this was in line with other studies in different animal models of inflammation [61][62][63][64][65][66][67][68][69][70]. Thirdly, we endorsed this COX-2 and TGF Beta-1 coordinated relation results further by a correlation studies that showed for the first time a strong correlation between COX-2 and TGF Beta-1 in dermal wounds.…”

Section: Discussionsupporting

confidence: 89%

“…Inflammatory phase of dermal wound determines the quality of the post wounding scars. While the reduction of inflammatory response with early wound closure achieved by Celecoxib application at early time point could be attributed to its direct anti-inflammatory effect [62][63][64]. The improved scar quality could be attributed to an indirect antifibrotic effect of Celecoxib through reducing wound TGF Beta-1 [61,62] with subsequent reduction in collagen deposition and scar formation [89].…”

Section: Discussionmentioning

confidence: 99%

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Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

El-Aleem¹,

Jude²

2017

J Cytol Histol

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Background: Wound healing is a highly ordered dynamic process associated with inflammation at early stages and with permanent scarring at late stages. Scars could be disfiguring and could advance to be hypertrophic or keloid scars, this would have a strong physical and psychological impact on the patients afterward. The role of inflammatory mediators which could be pro-or anti-inflammatory, pro-or -anti fibrotic was the focus of wound healing research for decades and the balance between them is the key factor determining the outcome of healing.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

El-Aleem¹,

Jude²

2017

J Cytol Histol

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“…There are at least two isozymes of cyclooxygenase namely COX-1 and COX-2. The latter functions together with prostaglandin E2 produced by fibroblasts 23) Moreover, COX-2 was described to control many aspects of inflammatory reactions and activation of inflammatory cells 24) . Immunohistochemical localization of COX-2 appeared in wound margin in particular 25) .…”

Section: Discussionmentioning

confidence: 99%

So-called ^|^ldquo;Denture Fibroma^|^rdquo;: A Histopathological and Immunohistochemical Study

Wakami

Kuyama

Sun

et al. 2012

J. Hard Tissue Biology.

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The purpose of this study was to investigate the histopathological and immunohistochemical characteristics of so-called "denture fibroma" and related stromal reaction. The tissues were histologically classified into inflammatory granulation type, matured fibrous type and myxoid type. Tenascin, LOX, fibrinogen and COX were strongly detected in inflammatory granulation type whereas a weak expression was detected in matured fibrous type. LOX was remarkably expressed by spindle shaped cells/fibroblastic cells and endothelial cells while tenascin was relatively expressed by monocytes in myxoid type. Despite strong expressions of tenascin, fibrinogen, COX-2 and LOX, their expressions decreased towards the deep part of the connective tissue. The greatest number of vessels was obtained in inflammatory granulation type and the least number of vessels was obtained in myxoid type which might contribute to hypoxic condition.The results suggest that the so-called "denture fibroma" is a consequence of acute inflammatory reaction leading to the formation of inflammatory granulation followed by the state of fibrosis which gradually was replaced by matured collagen fibers. Furthermore, myxoid degeneration occurred when blood vessels decreased which lead to hypoxic condition.

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“…[6] Meloxicam is a lipophilic drug with a logP of 3.4 having good transdermal penetration. [7] In addition, literature revealed that topical application of cyclooxygenase inhibitors suppresses ultraviolet B (UVB)-mediated cutaneous inflammation. Therefore, topical application of meloxicam seems to have another important role inhibiting UVB-mediated inflammation as well as its systemic anti-inflammatory effects without major GI side effects.…”

Section: Eloxicam (4-hydroxy-2-methyl-n-(5-methyl-13-thiazol-2-yl)mentioning

confidence: 99%

Untitled

Powar

2016

AJP

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Aim: Aim of the present investigation is to develop meloxicam incorporated Aloe vera gel (MAG) and to study its pharmacodynamics and in vitro evaluation studies. Materials and Methods: 2 3 factorial design was used to optimize the independent variables as amount of hydroxy propyl methyl cellulose (HPMC) (X1), amount of carboxy methyl cellulose (CMC) (X2), and amount of Carbopol 934 (X3) as gelling agent at varying concentration, i.e. 1% and 2%. Total 8 batches (F1-F8) were prepared and evaluated for gel consistency, spreadability, drug content, physicochemical parameters such as pH, viscosity, and in vitro diffusion assessment. Pharmacodynamic activity of MAG (batch F8) was evaluated in Wistar albino rats and compared with commercially available marketed cream (MC) against the same parameters. Results: Batch F8 containing a higher concentration of Carbopol 934, HPMC, and CMC shows improved gel consistency, with good spreadability, viscosity, and drug content. These results indicate the suitability of 2 3 factorial design for fabrication of MAG. Noteworthy, batch F8 showed significant (P < 0.05) in vitro drug release (76.72%) compared to marketed formulation (70.56%) at 150 min. Percentage inhibition of edema was greater for the batch F8 (26.48%) compared to MC (20.32%) after 60 min. This improved efficacy might be due to direct stimulation of the activity of macrophages and fibroblasts by A. vera gel and binding of mannose 6-phosphate to the growth factor receptors on the surface of the fibroblasts, thereby promoting tissue repair. Conclusion: Hence, decisively A. vera gel serves as an effective gel base to incorporate meloxicam with high drug loading capacity.

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Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation

Cited by 123 publications

References 62 publications

Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

Inhibition of Wound TGF Beta-1 by Celecoxib: A Possible Therapeutic Route for Scar Free Wound

So-called ^|^ldquo;Denture Fibroma^|^rdquo;: A Histopathological and Immunohistochemical Study

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