Topical Application of Metal Allergens Induces Changes to Lipid Composition of Human Skin

Knox, Sophie; Hagvall, Lina; Malmberg, Per; O’Boyle, Niamh M.

doi:10.3389/ftox.2022.867163

Cited by 4 publications

(2 citation statements)

References 49 publications

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“…Co also raised the monoacylglycerols (MAG) level in the epidermis. In contrast, Ni reduced DAG and MAG in the epidermis [ 79 ].…”

Section: Mechanisms and Biomarkersmentioning

confidence: 99%

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

Zemelka‐Wiącek¹

2022

JCM

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Metal allergy is mainly an environmental disorder which can cause allergic contact dermatitis. Environmental metal exposures include jewelry, everyday metal items, mobile phones, leather, metal-rich food and implants, including stents or anchors. While consumer exposure is liable for the majority of metal hypersensitivity cases, the significance of occupational exposure to metals remains relevant. Although the most common metal allergens are nickel, chromium, and cobalt; however, lately, gold, palladium, titanium, and some others have also attracted attention. This review highlights advances in metal allergy mechanisms, biomarkers for potential patients’ stratification as well as biological treatments. The most recent evidence of human exposure to metal for risk assessment is discussed, as well as the relationship between the occurrence of metal hypersensitivity and implanted devices, including non-characteristic symptoms. The latest data on the diagnosis of metal hypersensitivity are also reported.

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“…Co also raised the monoacylglycerols (MAG) level in the epidermis. In contrast, Ni reduced DAG and MAG in the epidermis [ 79 ].…”

Section: Mechanisms and Biomarkersmentioning

confidence: 99%

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

Zemelka‐Wiącek¹

2022

JCM

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“…Foreign authors study the problems of diagnosing possible allergic reactions to medical products based on titanium alloys [17][18][19][20][21][22]. It should be noted that a modified test for sensitisation or delayed-type hypersensitivity (DTH) to the surface of certified titanium alloy medical devices has now been developed under laboratory conditions before surgical intervention [23].…”

Section: Introductionmentioning

confidence: 99%

Emission and Migration of Nanoscale Particles during Osseointegration and Disintegration of Dental Implants in the Clinic and Experiment and the Influence on Cytokine Production

Labis

Bazikyan

Сизова

et al. 2023

IJMS

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The emission of nanoscale particles from the surfaces of dental implants leads to the cumulative effect of particle complexes in the bone bed and surrounding soft tissues. Aspects of particle migration with the possibility of their involvement in the development of pathological processes of systemic nature remain unexplored. The aim of this work was to study protein production during the interaction of immunocompetent cells with nanoscale metal particles obtained from the surfaces of dental implants in the supernatants. The ability to migrate nanoscale metal particles with possible involvement in the formation of pathological structures, in particular in the formation of gallstones, was also investigated. The following methods were used: microbiological studies, X-ray microtomography, X-ray fluorescence analysis, flow cytometry, electron microscopy, dynamic light scattering, and multiplex immunofluorescence analysis. For the first time, titanium nanoparticles in gallstones were identified by X-ray fluorescence analysis and electron microscopy with elemental mapping. The multiplex analysis method revealed that the physiological response of the immune system cells, in particular neutrophils, to nanosized metal particles significantly reduced TNF-a production both through direct interaction and through double lipopolysaccharide-induced signaling. For the first time, a significant decrease in TNF-a production was demonstrated when supernatants containing nanoscale metal particles were co-cultured with proinflammatory peritoneal exudate obtained from the peritoneum of the C57Bl/6J inbred mice line for one day.

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Metabolipidomic changes induced by dermal nickel penetration determined in an ex vivo porcine ear skin model

Rezaei,

Ganashalingam,

Schindler

et al. 2024

Rapid Comm Mass Spectrometry

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RationalNickel is one of humans' most prevalent triggers of allergic contact dermatitis. However, the underlying mechanisms of this allergy still need to be fully understood. One aspect that has yet to be explored is the direct impact of common metal allergens on the skin's metabolites and lipids composition.MethodOur study employed matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) to analyze spatially resolved metabolic alterations induced by nickel exposure. Cross‐sections of ex vivo porcine ear skin exposed to increasing nickel (II) ion concentrations (17–167 μg/cm2) were measured with an AP‐SMALDI5 AF ion source coupled to Q Exactive HF Orbitrap mass spectrometer. Additionally, the penetration of nickel ions into the skin was observed through its pink complexation with dimethylglyoxime under light microscopy.ResultsFor nickel ion concentrations up to 84 μg/cm2, most nickel ions were stopped within the stratum corneum, while only a very small proportion of nickel ions penetrated the viable epidermis and dermis. Stratum corneum locations with high nickel ion concentrations showed a decrease in arginine and ceramides. Furthermore, several phosphatidylcholine and sphingomyelin species were found to be downregulated in the viable epidermis and dermis due to the nickel exposure.ConclusionNickel penetrates at a trace level into the viable skin and induces severe metabolomic and lipidomic changes in the stratum corneum, epidermis, and dermis, indicating a change in the skin (barrier) function. These findings contribute to a deeper understanding of nickel‐induced skin allergies and provide a solid foundation for further research.

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Topical Application of Metal Allergens Induces Changes to Lipid Composition of Human Skin

Cited by 4 publications

References 49 publications

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

Emission and Migration of Nanoscale Particles during Osseointegration and Disintegration of Dental Implants in the Clinic and Experiment and the Influence on Cytokine Production

Metabolipidomic changes induced by dermal nickel penetration determined in an ex vivo porcine ear skin model

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