Topical application of NADH for the treatment of rosacea and contact dermatitis

Abstract

Among many important physiological functions played by NADH (the reduced form of beta-nicotinamide adenine dinucleotide) its antioxidative properties are remarkable. Acting directly as an antioxidant, NADH can effectively protect the cell and its membrane from destruction by free radicals. NADH can be stabilized as a suspension in hydrophobic ointments prepared in a way that prevents contact with atmosphere containing oxygen and water. We present the first report of NADH as a treatment for some inflammatory dermatoses. It was found that topical application of 1% NADH diluted in Vaseline ointment can be very effective in the treatment of rosacea and contact dermatitis. Since no adverse effects were observed, therapy with NADH can be viewed as a potential alternative to other established treatments.

Nicotinamide – biologic actions of an emerging cosmetic ingredient

“…There has been no post-inflammatory desquamation or skin dryness noticed. NADH is discussed as a safe alternative to conventional treatment of inflammatory skin disease like rosacea and contact dermatitis [13].…”

Plasma reactive oxygen species activity and antioxidant potential levels in rosacea patients: correlation with seropositivity to Helicobacter pylori

“…Intrafollicular neutrophils, which release potent inflammatory mediators, including ROS, have been observed in stage II disease 1 . In addition, effective treatment of the disease with topical 21 or systemic 22,23 drugs with remarkable antioxidant properties suggests that rosacea may be related to increased ROS activity and deficient function of the antioxidant system of the individual.…”

In Search for New Antipsoriatic Agents: NAD⁺ Topical Composition

“…Those findings encouraged us to return to the concept of purines as antipsoriatic agents by employing NAD + as their precursor. Our previous studies [14][15][16] on mechanistic aspects concerning oxidation of the reduced ␤ -nicotinamide adenine dinucleotide (NADH) analogs have led to favorable effects of NADH application in the treatment of some inflammatory dermatoses [17] .…”

“…The degree of NAD + decomposition during storage of the ointment was determined by the enzymatic method. The simple spectrophotometric method that was previously applied [17] to determine NADH stability would be useless in the case of NAD + as this compound and the products of its degradation absorb in the same spectral region.…”