Topical application of α‐tocopherol modulates the antioxidant network and diminishes ultraviolet‐induced oxidative damage in murine skin

López-Torres, Mónica; Thiele, Jens J.; Shindo, Yasuko; Han, Derick; Packer, Lester

doi:10.1046/j.1365-2133.1998.02062.x

Cited by 183 publications

(99 citation statements)

References 63 publications

(101 reference statements)

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“…The main advantage of the topical administration when compared to the oral administration to treat and prevent skin conditions is the direct delivery of bioactive substances to the target area, thus eliminating concerns about systemic circulation Page 2 / 10 (Meinke et al, 2010;Palombo et al, 2007). The cutaneous delivery of antioxidants is a complementary and well known treatment to prevent skin aging and to avoid dermal diseases, such as skin cancer (Sander et al, 2004;Pinnell, 2003;Dreher et al, 1998;Lopez-Torres et al, 1998). Pinnell (2003) explains that antioxidants are an important alternative to protect the skin from photodamage, and should be associated with sunscreens.…”

Section: Introductionmentioning

confidence: 99%

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Chiari-Andréo

Trovatti

Marto

et al. 2017

Braz. J. Pharm. Sci.

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Guava (Psidium guajava L.) is a native fruit of the American tropics with commercial applications for its taste, flavor and aroma. Numerous pharmacological uses have been described for it, such as the antiseptic effect of its leaves, the use of the fresh fruit and tea from its leaves for the treatment of diarrhea, dysentery, diabetes mellitus, and others. However, considering its rich composition, the guava also is a potential source of antioxidants to be used in the development of new formulations for cosmetic and/or dermatological applications, the main focus of this research. Herein, we describe the study of the phytochemical composition and the antioxidant activity of a guava extract prepared with non-toxic solvents aiming its use at biological applications. High performance liquid chromatography and mass spectrometry were employed to identify the major components, while thermoanalytical measurements and hot stage microscopy were used to assess the chemical stability of guava fruit extract. The antioxidant activity was also evaluated assessing the SOD-like activity and ABTS free radical scavenger. The results show that the extract is a rich source of phenolic compounds, such as quercetin, kaempferol, schottenol, among many others. All of the components found in guava extract exhibit biological effects according to the literature data, mainly antioxidant properties. Uniterms

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Section: Introductionmentioning

confidence: 99%

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Chiari-Andréo

Trovatti

Marto

et al. 2017

Braz. J. Pharm. Sci.

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“…These effects are mediated in part by UV induced oxidative stress through ROS production (20) cou pled to the impairment of tissue antioxidant defense systems (21). Several studies have indicated that topical applications of antioxidants like a-tocopherols have photoprotective effects on the epidermis in different models of UV photodamage, protecting cutaneous tissues from oxidative damage induced by UV irradiation in vivo (22)(23). The high level of 8iso-PGF2a found in UV irradiated skin and in BCC could also have an intrinsic biologic acti vity 8iso-PGF2 is a well-known mitogen for endothelial cell (24) neutrophil adhesion (25) and cytokine's production (26)(27).…”

Section: Discussionmentioning

confidence: 99%

Elevated 8-Isoprostane Levels in Basal Cell Carcinoma and in Uva Irradiated Skin

Belli

Amerio

Brunetti

et al. 2005

Int J Immunopathol Pharmacol

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Isoprostanes are prostaglandin isomers produced from the peroxidation of polyunsaturated fatty acids from the cellular membrane. They have been used as a specific index of cellular Iipoperoxidation and as an indirect measure of oxidative stress. However, these molecules also present several biological activities. An oxidative environment measured as the presence of other indirect measurements of reactive oxygen species Iipoperoxidation has recently been described in basal cell carcinoma, the most frequent type of non-melanoma skin cancer. This study aims to measure the levels of 8-isoprostaglandin F2a, an isoprostane widely studied in other models as a by-product of ROS-induced lipid peroxidation, in basal cell carcinoma and in UVA irradiated healthy skin. We found that 8-iso-PGF2a is present in higher levels in Bee specimens compared to healthy non sun-exposed skin, confirming previous studies on the production of Iipoperoxidation in this tumor. Moreover, we demonstrated that topical pre-treatment with a compound containing vitamin E is capable of reducing 8-iso-PG}<'2a fncmation in UV irradiated skin suggesting a role for isoprostanes in UV induced inflammation and eventually carcinogenesis and confirming the function of vitamin E as an antioxidant in this model. F2 isoprostanes are a family of prostaglandin isomers produced by non-enzymatic free radical catalyzed peroxidation ofpolyunsaturated fatty acids from the cellular membrane. Due to their chemical stability isoprostanes can be seen as a sensitive and specific index of cellular lipoperoxidation in biological fluids and human tissues as shown by in vitro and in vivo studies.(l) Measurement of isoprostanes has been shown to be more reliable than other commonly used tests to measure the degree of oxatidative stress (2).8-iso-Prostaglantin-F2a (8-isoPGF2a) is the most widely studied F2 isoprostane and, besides its role as an indirect index of lipid peroxidation, it presents several biological activities mediated through tromboxane A2 receptor (3-4).Basal Cell Carcinoma (BCC) is a very common cutaneous cancer in Caucasians, locally invasive, with a low metastatic potential (5). Previous studies have demonstrated the presence of an "oxidative microenvironment" in BCC evaluated by different oxidative stress markers such as the thiobarbituric acid reactive substances (TBARS) a lipoperoxidation

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“…This comprehensive system provides the skin with a protective antioxidant barrier and is well interlinked between its various components [44][45][46]. Most of the system's components were found distributed in skin layers, with higher concentrations in the epidermis than the dermis, correlating with ROS exposure of skin layers [47].…”

Section: Antioxidant Defense Systemmentioning

confidence: 99%

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

et al. 2016

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Abstract:The skin, being the largest organ of the body, functions as a barrier between our body and the environment. It is consistently exposed to various exogenous and endogenous stressors (e.g., air pollutants, ionizing and non-ionizing irradiation, toxins, mitochondrial metabolism, enzyme activity, inflammatory process, etc.) producing reactive oxygen species (ROS) and physical damage (e.g., wounds, sunburns) also resulting in reactive oxygen species production. Although skin is equipped with an array of defense mechanisms to counteract reactive oxygen species, augmented exposure and continued reactive oxygen species might result in excessive oxidative stress leading to many skin disorders including inflammatory diseases, pigmenting disorders and some types of cutaneous malignancy. The nuclear factor erythroid 2-related factor 2 (Nrf2) is an emerging regulator of cellular resistance and of defensive enzymes such as the phase II enzymes. Induction of the Keap1-Nrf2 pathway may have a beneficial effect in the treatment of a large number of skin disorders by stimulating an endogenous defense mechanism. However, prolonged and enhanced activation of this pathway is detrimental and, thus, limits the therapeutic potential of Keap1-Nrf2 modulators. Here, we review the consequences of oxidative stress to the skin, and the defense mechanisms that skin is equipped with. We describe the challenges of maintaining skin redox balance and its impact on skin status and function. Finally, we suggest a novel strategy for maintenance of skin redox homeostasis by modulating the Keap1-Nrf2 pathway using nanotechnology-based delivery systems.

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Topical application of α‐tocopherol modulates the antioxidant network and diminishes ultraviolet‐induced oxidative damage in murine skin

Cited by 183 publications

References 63 publications

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Guava: phytochemical composition of a potential source of antioxidants for cosmetic and/or dermatological applications

Elevated 8-Isoprostane Levels in Basal Cell Carcinoma and in Uva Irradiated Skin

Skin Redox Balance Maintenance: The Need for an Nrf2-Activator Delivery System

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