Topical aspects of the chronic periodontitis immunopathogenesis (review)

Антонов, И. И.; Мудров, В. П.; Nelyubin, V. N.; Мураев, А. А.

doi:10.37988/1811-153x_2021_1_46

Cited by 2 publications

(1 citation statement)

References 56 publications

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“…The complexity and diversity of factors influencing the separate phases of periodontitis pathogenesis, including a combination of polymicrobial synergy and dysbiosis, chronic inflammatory dysregulation, and genetic predisposition factors [ 4 , 14 , 15 ], have made the search for an ideal animal model of periodontitis difficult and challenging [ 9 ]. In addition, the pathogenesis of comorbid conditions aggravated by periodontitis is still poorly understood.…”

Section: Introductionmentioning

confidence: 99%

A New Way to Model Periodontitis in Laboratory Animals

Moiseev,

Donskov,

Dubrovin

et al. 2023

Dentistry Journal

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The prevalence of periodontal diseases is increasing, tends to increase with age and is considered as one of the main causes of tooth loss. To assess the effectiveness of new methods of treatment of periodontal diseases, studies on laboratory animals can be promising. The aim of the study: to develop a new method of accelerated modeling of experimental periodontitis on laboratory animals. Material and methods. The study was carried out on 22 female rats. A wire ligature was applied to the cervical area of the incisors of the animals in an eight-shaped manner. Plaque obtained from a patient with periodontitis was placed under the wire, and nicotine and ethyl alcohol solutions were injected under the gingival mucosa. A complex index has been proposed to assess inflammation. At the end of the experiment the animals were euthanized, their jaws were dissected into dentoalveolar blocks and further descriptive histologic analysis was performed. Results. On the second day the gingiva of the rats acquired a cyanotic-pink color, on the fourth day the consistency of the gingiva became friable, mobility appeared in the lower incisors. Complex index of inflammation in animals of the main group: before the study—9, on the 7th day—195. Gingival preparations showed signs of exudative inflammation. In alveolar processes—irreversible resorption of bone structures. The difference of indicators in animals before and after the experiment was statistically significant (p < 0.05). Conclusion. The new experimental model of periodontitis is reproduced in a short period of time, provides intensive development of inflammation, leads to disruption of the integrity of epithelial and connective tissue attachment, destruction of alveolar bone.

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Section: Introductionmentioning

confidence: 99%

A New Way to Model Periodontitis in Laboratory Animals

Moiseev,

Donskov,

Dubrovin

et al. 2023

Dentistry Journal

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Clinical substantiation of the use of connective tissue graft transplantation technique as a surgical stage for deepening the oral cavity opening in the treatment of periodontitis

2022

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The aim of the work was to evaluate the effectiveness of vestibuloplasty with free gingival graft transplantation in patients with small oral cavity opening in the treatment of severe periodontitis. The study group consisted of 14 patients who, in the period from 2020 to 2022, on the basis of the Department of Maxillofacial Surgery of the RUDN, 14 operations were performed to deepen the vestibule of the oral cavity with the insertion of a free graft from the palate. The measurements were carried out before and 6 months after the surgical treatment with a graduated periodontal probe, the surgical operation was preceded by a conservative stage of treatment. Following the results of the vestibuloplasty operation, the depth of the vestibule in the study group increased by an average of 3.63 times (from 1.32 to 5.06 mm). An increase in the depth of the vestibule of the oral cavity was observed in all cases of treatment. The conclusion is made about the effectiveness of using this technique in the treatment of periodontitis with destructive changes in periodontal tissues in the frontal part of the mandible.

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Topical aspects of the chronic periodontitis immunopathogenesis (review)

Cited by 2 publications

References 56 publications

A New Way to Model Periodontitis in Laboratory Animals

A New Way to Model Periodontitis in Laboratory Animals

Clinical substantiation of the use of connective tissue graft transplantation technique as a surgical stage for deepening the oral cavity opening in the treatment of periodontitis

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