Topical Benefits of Two Fucoidan-Rich Extracts from  Marine Macroalgae

Fitton, J. Helen; Dell'Acqua, Giorgio; Gardiner, Vicki-Anne; Karpiniec, Samuel S.; Stringer, Damien N.; Davis, Emma

doi:10.3390/cosmetics2020066

Cited by 90 publications

(66 citation statements)

References 25 publications

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“…Fernando et al [142] concluded that brown algae sulfated polysaccharides have notable antioxidative and anti-inflammatory properties and are able to inhibit collagenase, elastase and tyrosinase therefore causing anti-wrinkling and skin-whitening effects. Brown algae extracts evaluated in the research of Fitton et al [143] positively affected skin protection, soothing and spot reduction.…”

Section: Brown Algae Sulfated Polysaccharides As Drug Delivery Systemmentioning

confidence: 95%

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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Over the years, brown algae bioactive polysaccharides laminarin, alginate and fucoidan have been isolated and used in functional foods, cosmeceutical and pharmaceutical industries. The extraction process of these polysaccharides includes several complex and time-consuming steps and the correct adjustment of extraction parameters (e.g., time, temperature, power, pressure, solvent and sample to solvent ratio) greatly influences the yield, physical, chemical and biochemical properties as well as their biological activities. This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process. The influence of these extraction techniques and their individual parameters on yield, chemical structure and biological activities from the most current literature is discussed, along with their potential for commercial applications as bioactive compounds and drug delivery systems.(APS) is determined by algae species however it is also influenced by other factors causing inter-species variation, e.g., growth location and harvesting season [8]. Vast structural variation between the APS therefore presents a challenge in terms of pre-treatments application, extraction techniques and optimization, characterization of isolated fractions and determination of their biological properties.Chemical structure and yield of APS isolated from marine macroalgae by conventional extraction (CE) techniques can be affected by various experimental conditions (pH, time, temperature, pressure, particle size, solvent, sample to solvent ratio, agitation speed etc.). In addition, different advanced techniques such as microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), pressurized liquid extraction (PLE), enzyme-assisted extractions (EAE) are assessed and applied for APS extraction [9][10][11].In general, the chemical structure of polysaccharides determines its physical, chemical and biochemical properties as well as its biological activities [12]. Several studies have reported that their biological activity is strongly associated with their chemical structure [9]. Due to very complex mechanisms that are affected by many factors, the correlation between polysaccharide structure and biological activity is still not sufficiently clarified.In order to improve isolation of APS, pre-treatments are usually applied to the algal biomass prior to the extraction process with the two aims: (i) to prevent co-extraction of interfering bioactive compounds with similar solubility; and (ii) to disrupt cell walls and improve mass transfer of APS into extraction solvent. The first type of pre-treatments is therefore used to remove compounds which are highly bound to the APS such as proteins, phenols and lipids, as well as mannitol and chlorophyll [13]. For that purpose, the application of various pr...

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Section: Brown Algae Sulfated Polysaccharides As Drug Delivery Systemmentioning

confidence: 95%

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

et al. 2020

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“…Double-blind clinical trials with fucoidan extracts show anti-aging effects on skin and other benefits in cosmetic applications (Fitton et al 2015). A common source of FCPs used in experimental studies is Fucus vesiculosus , but fucoidans also are found in edible species such as Cladosiphon okamuranus , Saccharina japonica ( as Laminaria japonica ), and Undaria pinnatifida (Fitton 2011).…”

Section: Polysaccharidesmentioning

confidence: 99%

Algae as nutritional and functional food sources: revisiting our understanding

et al. 2016

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Global demand for macroalgal and microalgal foods is growing, and algae are increasingly being consumed for functional benefits beyond the traditional considerations of nutrition and health. There is substantial evidence for the health benefits of algal-derived food products, but there remain considerable challenges in quantifying these benefits, as well as possible adverse effects. First, there is a limited understanding of nutritional composition across algal species, geographical regions, and seasons, all of which can substantially affect their dietary value. The second issue is quantifying which fractions of algal foods are bioavailable to humans, and which factors influence how food constituents are released, ranging from food preparation through genetic differentiation in the gut microbiome. Third is understanding how algal nutritional and functional constituents interact in human metabolism. Superimposed considerations are the effects of harvesting, storage, and food processing techniques that can dramatically influence the potential nutritive value of algal-derived foods. We highlight this rapidly advancing area of algal science with a particular focus on the key research required to assess better the health benefits of an alga or algal product. There are rich opportunities for phycologists in this emerging field, requiring exciting new experimental and collaborative approaches.Electronic supplementary materialThe online version of this article (doi:10.1007/s10811-016-0974-5) contains supplementary material, which is available to authorized users.

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“…This has been demonstrated successfully using several terrestrial plant extracts [137,138], but marine sources have received less attention. Recently, sulphated polysaccharide fucoidan was obtained from the phaeophyte Undaria pinnatifida and was shown to inhibit bacterial collagenase and human neutrophil elastase in vitro [139]. Additionally, a polyphenolic extract, containing fucoidan from the Figure 3 Approximate dry mass yields of collagen from different marine sources; fish skin and bone [127][128][129][130], cephalopods [134,135], echinoderm tests [131] and cnidarians [132,133].…”

Section: Collagenmentioning

confidence: 99%

The promise of marine molecules as cosmetic active ingredients

Brunt

Burgess

2017

Intern J of Cosmetic Sci

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The marine environment represents an underexploited resource for the discovery of novel products, despite its high level of biological and chemical diversity. With increasing awareness of the harmful effects of chronic ultraviolet exposure, and a universal desire to improve cosmetic appearance, the market for new cosmetic ingredients is growing, and current trends have generated a greater demand for products sourced from the environment. A growing number of novel molecules from marine flora and fauna exhibit potent and effective dermatological activities. Secondary metabolites isolated from macroalgae, including carotenoids and polyphenols, have demonstrated antioxidant, anti-ageing and anti-inflammatory activities. In addition, marine extremophilic bacteria have recently been shown to produce bioactive exopolymeric molecules, some of which have been commercialized. Available data on their activities show significant antioxidant, moisturizing and anti-ageing activities, but a more focussed investigation into their mechanisms and applications is required. This review surveys the reported biological activities of an emerging and growing portfolio of marine molecules that show promise in the treatment of cosmetic skin problems including ultraviolet damage, ageing and cutaneous dryness.R esum e L'environnement marin repr esente une ressource sous-exploit ee pour la d ecouverte de nouveaux produits, malgr e son niveau elev e de diversit e biologique et chimique. Avec la prise de conscience croissante des effets n efastes de l'exposition chronique aux ultraviolets et un d esir universel d'am eliorer l'apparence, le march e des nouveaux ingr edients cosm etiques est en croissance et les tendances actuelles ont g en er e une plus grande demande pour les produits issus de l'environnement. Un nombre croissant de nouvelles mol ecules issues de la flore et de la faune marines pr esentent des activit es dermatologiques efficaces et performantes. Les m etabolites secondaires isol es des macroalgues, y compris les carot eno€ ıdes et les polyph enols, ont d emontr e des activit es antioxydantes, antivieillissement et anti-inflammatoires. De plus, il a et e d emontr e r ecemment que les bact eries extrêmophiles marines produisent des mol ecules exopolym eriques bioactives, dont certaines ont et e commercialis ees. Les donn ees disponibles sur leurs activit es montrent des activit es antioxydantes, hydratantes et anti-ages significatives, mais une investigation plus cibl ee de leurs m ecanismes et applications est requise. Cette revue etudie les activit es biologiques rapport ees d'une gamme emergente et croissante de mol ecules marines prometteuses, dans le traitement des probl emes de peau cosm etiques, y compris les dommages caus es par les ultraviolets, le vieillissement et la s echeresse cutan ee.

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Topical Benefits of Two Fucoidan-Rich Extracts from Marine Macroalgae

Cited by 90 publications

References 25 publications

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Advanced Technologies for the Extraction of Marine Brown Algal Polysaccharides

Algae as nutritional and functional food sources: revisiting our understanding

The promise of marine molecules as cosmetic active ingredients

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