Topical butyrate improves efficacy of 5‐ASA in refractory distal ulcerative colitis: results of a multicentre trial

Vernia, Piero; Annese, Vito; Bresci, G.; d’Albasio, G; D’Incà, R.; Giaccari, S.; Ingrosso, M.; Mansi, C.; Riegler, G.; Valpiani, D.; Caprilli, R.; Gisc,; Retto, del

doi:10.1046/j.1365-2362.2003.01130.x

Cited by 189 publications

(177 citation statements)

References 24 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…Although a decreased butyrate oxidation was observed in active ulcerative colitis (Den Hond et al, 1998), there was, however, no difference between controls and patients with quiescent colitis, speaking against a primary defect in colonic butyrate oxidation (Simpson et al, 2000). Some studies demonstrate a therapeutic effect of rectal butyrate and mixed CAs in distal colitis (Scheppach et al, 1992;Vernia et al, 2003). Although well-controlled clinical trials have not fully verified this finding (Scheppach, 1996;Steinhart et al, 1996), they suggest that butyrate may be effective in a subset of patients.…”

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with β-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects

et al. 2007

View full text Add to dashboard Cite

Background/Objective: Carboxylic acids (CAs), especially butyric acid, have been suggested to counteract colonic diseases, such as ulcerative colitis and colon cancer. Colonic formation of CAs can be influenced by the diet, but the concentrations and pattern formed need to be evaluated for different food products in humans. To elucidate how the colonic concentration of CAs in healthy subjects is influenced by dietary supplementation with oat bran, and whether the concentration varies over time and during consecutive days. Subjects/Methods: Twenty-five healthy subjects (age 2471.3) were recruited to the study. The subjects were given 40 g b-glucan enriched oat bran per day, corresponding to 20 g dietary fibre, in 4 slices of bread. CAs were analysed in faeces during three consecutive days after 0, 4, 8 and 12 weeks on this diet. Results: The concentration of acetic, propionic, butyric, isobutyric and isovaleric acid was higher (Po0.05-0.001) after 8 weeks on the oat bran diet as compared with values at entry, whereas that of lactic acid was lower (Po0.05). After 12 weeks, the concentrations of acetic, propionic and isobutyric acid were still higher and that of lactic acid lower. The variation between individuals was considerable, whereas in the same individuals there was little variation. Conclusions: Oat bran increased the faecal concentration of CAs after 8 weeks, indicating an increased concentration also in the distal colon. The concentration of all main acids increased, except for lactic acid, which decreased. Oat bran may therefore have a preventive potential adjunct to colonic diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Dietary supplementation with β-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects

et al. 2007

View full text Add to dashboard Cite

show abstract

“…There is evidence that SCFAs in colon feces are decreased in human UC and also in DSS-induced colitis [31,32]. Use of n-butyrate enema has been proposed for the treatment of refractory distal UC [10,11]. Moreover, n-butyrate may exert anti-inflammatory effects by suppressing the activation of the TNF-a-induced nuclear factor (NF)-jB [33].…”

Section: Discussionmentioning

confidence: 99%

“…Generally, dietary carbohydrates that escape digestion in the small intestine undergo bacterial fermentation in the colon and generate short-chain fatty acids (SCFAs). One of the SCFAs, n-butyrate, is used in the treatment of distal ulcerative colitis (UC) [10,11].…”

Section: Introductionmentioning

confidence: 99%

Effects of Proteoglycan on Dextran Sulfate Sodium-Induced Experimental Colitis in Rats

et al. 2008

View full text Add to dashboard Cite

Proteoglycans (PG) are macromolecules composed of glycosaminoglycan chains covalently attached to a protein core. In this study, we examined the effects of PG on dextran sulfate sodium (DSS)-induced experimental colitis in rats. First, to examine whether PG may ameliorate acute established DSS colitis, PG was administered orally for 5 days to the model animals. We evaluated the effects of PG on the basis of clinical symptoms, hematological analysis, macroscopic observation, and microscopic examination. We then examined whether PG administered orally to rats was detectable in their colonic lumen. After administration of PG, the colonic contents were collected, and the molecular weight of PG in the sample was analyzed by gel filtration high-performance liquid chromatography. Furthermore, we examined whether orally administered PG affected the concentrations of short-chain fatty acids (SCFAs) in the colonic feces. Orally administered PG ameliorated the clinical symptoms of bloody stools and diarrhea, and attenuated the increase in the white blood cell count in rats with established DSS colitis. Histologically, orally administered PG reduced the degree of mucosal erosion and inflammatory cell infiltration into the erosive area induced by DSS. Orally administered PG was detected in rat colon, although its molecular weight was slightly decreased. Orally administered PG significantly increased the concentration of total SCFAs and n-butyrate in rat colonic feces. This is the first study to indicate that exogenous PG ameliorates experimental colitis, suggesting the potential usefulness of PG for clinical treatment of colitis.

show abstract

“…[9][10][11] UC is a chronic inflammatory disorder of the colon that is characterized by alternating periods of flareups and quiescent disease. 35,36 It is generally considered that the disorder is the result of an exaggerated intestinal host response against luminal bacteria or their components, particularly in genetically susceptible individuals.…”

Section: Anti-inflammatory Role Of Butyric Acid Via Mfg-e8mentioning

confidence: 99%

“…7,8 In humans, butyrate enemas are used as therapy for inflammatory bowel disease as well as a variety of other diseases characterized by colonic inflammation. [9][10][11] However, the detailed mechanisms initiated by butyrate related to its protective effects have not been completely elucidated.…”

mentioning

confidence: 99%

Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8

Mishiro

Kusunoki

Otani

et al. 2013

Laboratory Investigation

View full text Add to dashboard Cite

Butyric acid, a short-chain fatty acid and one of the main metabolites of intestinal microbial fermentation of dietary fiber, has been shown to have an important role in maintaining the integrity of the intestinal mucosa, while it also has been shown to exert potent anti-inflammatory effects both in vitro and in vivo. However, the precise mechanisms underlying those effects have not been fully identified. We exposed colonic epithelial cells to butyric acid, then extracted total RNA samples, and subsequently hybridized them to microarray chips. Among the upregulated genes, milk fat globuleepidermal growth factor 8 (MFG-E8) was elevated by approximately fivefold. We previously reported that the potential therapeutic benefits of MFG-E8 in intestinal tissue injury were dependent not only on enhanced clearance of apoptotic cells but also required diverse cellular events for maintaining epithelial integrity. The influence of butyric acid on cell function is often attributed to its inhibition of histone deacetylases (HDACs). We found that acetylation on histone 3 lysine 9 (acetyl-H3K9) around the MFG-E8 promoter was significantly increased with butyric acid exposure. Experimental colitis was induced by administration of dextran sodium sulfate (DSS) in C57BL/6N (MFG-E8 þ / þ ) and MFG-E8 À / À mice. Although the colonic bacterial compositions in wild-type (WT) and MFG-E8 À / À mice were not significantly different, intrarectal administration of butyric acid during an acute phase of colitis attenuated intestinal inflammatory parameters and inhibited body weight loss in the WT mice. Our novel findings suggest that butyric acid has significant antiinflammatory effects partly via MFG-E8 on DSS-induced murine experimental colitis.

show abstract

Topical butyrate improves efficacy of 5‐ASA in refractory distal ulcerative colitis: results of a multicentre trial

Cited by 189 publications

References 24 publications

Dietary supplementation with β-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects

Dietary supplementation with β-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects

Effects of Proteoglycan on Dextran Sulfate Sodium-Induced Experimental Colitis in Rats

Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8

Contact Info

Product

Resources

About