Topical caffeine-loaded nanostructured lipid carriers for enhanced treatment of cellulite: A 32 full factorial design optimization and in vivo evaluation in rats

Kassem, Ahmed Alaa; Asfour, Marwa Hasanein; El-Alim, Sameh Hosam Abd; Khattab, M.; Salama, Abeer

doi:10.1016/j.ijpharm.2023.123271

International Journal of Pharmaceutics

2023

DOI: 10.1016/j.ijpharm.2023.123271

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Topical caffeine-loaded nanostructured lipid carriers for enhanced treatment of cellulite: A 32 full factorial design optimization and in vivo evaluation in rats

Ahmed Alaa Kassem

Marwa Hasanein Asfour

Sameh Hosam Abd El-Alim

et al.

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Cited by 14 publications

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“…In recent years, nanocarriers have emerged as a global focal point in pharmaceutical and cosmetic sciences, with nanostructured lipid carriers (NLC) standing out as a particularly promising advancement [17][18][19][20][21] . NLC offer a host of advantageous attributes, ranging from heightened therapeutic efficacy to enhanced skin hydration and prolonged stability of encapsulated active ingredients [22,23] .…”

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Enhanced Topical Delivery of Rosehip Oil (RO) through Nanostructured Lipid Carriers (NLC)

Sağıroğlu

2024

Haydarpasa Numune Med J

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Introduction: Rosehip oil (RO) is rich in bioactive constituents with potential for various formulations. This investigation aims to design and analyze Nanostructured Lipid Carriers (NLC) containing RO to protect its delicate components, prolong RO's shelf life, and enhance its permeability. Methods: The NLC formulation was created using high shear homogenization, with RO as the liquid lipid and Compritol 888 ATO (C888) as the solid lipid. A series of assessments was conducted to evaluate encapsulation effectiveness, particle size distribution, polydispersity index, zeta potential, ex vivo skin penetration, and stability. Results: The NLCs showed uniform spherical morphology, average particle sizes of 180 nm, PDI below 0.3, and zeta potential around -30 mV. High encapsulation efficiency was also observed. Ex vivo experiments indicated improved Quercetin retention in both Stratum Corneum (SC) and viable epidermis/dermis layers with NLC-encapsulated RO compared to RO alone. Stability assessments showed that the NLC formulation remained stable at 4°C for at least 90 days. Discussion and Conclusion: The findings support NLC's efficacy in delivering active compounds to the skin, presenting an encouraging alternative for treating skin conditions.

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Enhanced Topical Delivery of Rosehip Oil (RO) through Nanostructured Lipid Carriers (NLC)

Sağıroğlu

2024

Haydarpasa Numune Med J

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Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices

Birla,

Khandale,

Bashir

et al. 2024

Drug Deliv. and Transl. Res.

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Novel anti-psoriatic nanostructured lipid carriers for the cutaneous delivery of luteolin: A comprehensive in-vitro and in-vivo evaluation

Hatem,

El-Kayal

2023

European Journal of Pharmaceutical Sciences

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Topical caffeine-loaded nanostructured lipid carriers for enhanced treatment of cellulite: A 32 full factorial design optimization and in vivo evaluation in rats

Cited by 14 publications

References 87 publications

Enhanced Topical Delivery of Rosehip Oil (RO) through Nanostructured Lipid Carriers (NLC)

Enhanced Topical Delivery of Rosehip Oil (RO) through Nanostructured Lipid Carriers (NLC)

Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices

Novel anti-psoriatic nanostructured lipid carriers for the cutaneous delivery of luteolin: A comprehensive in-vitro and in-vivo evaluation

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