Topical calcitriol (BPM31543) for the prevention of chemotherapy-induced alopecia (CIA): Efficacy findings from a phase I safety study.

Lacouture, Mario E.; Konner, Jason; Stevens, Janice R.; Brouwer, Susan; Narain, Niven R.; Ye, Ran; Ravipaty, Shobha; Sarangarajan, Rangaprasad; Akmaev, Viacheslav R; Jiménez, Joaquín J.; Belum, Viswanath Reddy; Kitts, Sarah; Ciccolini, Kathryn; Berman, Brian; Goldfarb, Shari

doi:10.1200/jco.2016.34.15_suppl.2564

Cited by 2 publications

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“…A phase I safety study found topical calcitriol to have a favorable safety and tolerability profile with potential CIAprevention activity at higher dose levels. 74 Avoiding chemical trauma or direct heat to the hair (eg, bleaching, perming, curling); using a soft pillowcase, hair brush, and shampoo; cutting hair shorter; and other CIA-limiting measures may also be suggested to patients receiving taxane-based chemotherapy, although evidence to support these interventions is lacking. 65 Preventive strategies for taxane-induced nail and skin changes include the use of FG or FS, CGP, cold water immersion, hydrating nail solution, and systemic corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

“…Aside from scalp hypothermia, topical calcitriol may inhibit alopecia in patients receiving taxane-based chemotherapy. A phase I safety study found topical calcitriol to have a favorable safety and tolerability profile with potential CIA-prevention activity at higher dose levels . Avoiding chemical trauma or direct heat to the hair (eg, bleaching, perming, curling); using a soft pillowcase, hair brush, and shampoo; cutting hair shorter; and other CIA-limiting measures may also be suggested to patients receiving taxane-based chemotherapy, although evidence to support these interventions is lacking …”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events

2018

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IMPORTANCE Chemotherapy-induced alopecia as well as nail and cutaneous changes occur in up to 89% of patients receiving taxane-based chemotherapy and are associated with cosmetic concerns, psychosocial distress, and overall morbidity.OBJECTIVE To review the efficacy and safety of interventions to prevent taxane-induced dermatologic adverse events.EVIDENCE REVIEW PubMed and Scopus databases were systematically reviewed for studies published in the English language from January 1, 1980, to August 13, 2018. Specific search terms included but were not limited to taxane, docetaxel, paclitaxel, prevent, nail, skin, hair, alopecia, and onycholysis. Primary clinical studies that detailed preventive interventions for taxane-induced dermatologic adverse events and that classified results according to a taxane-specific chemotherapy regimen were reviewed and graded according to a 5-point scale, modified from the Oxford Centre for Evidence-based Medicine.FINDINGS The 34 original reports that met the inclusion criteria consisted of 6 randomized clinical trials, 4 nonrandomized clinical trials, 18 cohort studies, 3 case-control studies, 1 cross-sectional study, and 2 case reports and involved a total of 5647 unique participants. A total of 22 studies addressed preventive interventions for alopecia associated with taxane use, whereas 12 studies focused on taxane-induced skin and nail changes. Specifically, 20 (95%) of 21 studies supported the use of either a cold cap or a scalp cooling system to reduce alopecia but reported substantial differences in efficacy depending on the chemotherapy regimen. Scalp cooling was generally considered safe by all pertinent studies despite a single report of scalp skin metastasis. Similarly, use of frozen gloves and frozen socks in the prevention of nail and cutaneous hand and foot toxic effects was considered safe in 7 (88%) of 8 studies, although discomfort was common and frostbite was noted in 1 patient. Overall, use of frozen gloves was endorsed by 4 (67%) of 6 studies to prevent nail toxic effects and by 3 (60%) of 5 studies to prevent cutaneous hand changes.CONCLUSIONS AND RELEVANCE Scalp hypothermia with cold caps or scalp cooling systems has demonstrated efficacy as a monotherapy in preventing taxane-induced alopecia, and use of frozen gloves and socks has been associated with reduced nail and skin changes. Future studies should establish the routine usage protocols, standard outcome measures, and long-term efficacy and safety for these interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events

2018

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Current and emerging treatments targeting the neuroendocrine system for disorders of the skin and its appendages

Soeberdt

Kilić

Abels

2020

Experimental Dermatology

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The skin as a neuroendocrine organ and the role of neuroendocrine signalling in the development of disorders affecting the skin and its appendages has received increasing attention in the last years. Different neuroendocrine systems have been described in the barrier organ skin, including the thyroid system, the hypothalamicpituitary-adrenal axis, the opioid, the endocannabinoid, the cholinergic, the secosteroidogenic and the serotonergic systems. All of these systems have been implicated in the development of skin diseases, which often have an inflammatory origin. These discoveries have led to an increase in the development of new drugs targeting components of neuroendocrine signalling pathways. Additionally, attempts have been made to repurpose already approved drugs targeting neuroendocrine signalling pathways in other organs for the treatment of skin diseases. Recently published results from preclinical and clinical studies look promising and may offer improved therapies to patients suffering from skin diseases in the near future. In this review, from a pharmaceutical point of view, we focus on recent progress in synthetic drug development of compounds targeting neuroendocrine signalling in the skin and its appendages to treat skin diseases such as atopic dermatitis, psoriasis, acne, alopecia areata and hyperhidrosis.

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Topical calcitriol (BPM31543) for the prevention of chemotherapy-induced alopecia (CIA): Efficacy findings from a phase I safety study.

Cited by 2 publications

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Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events

Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events

Current and emerging treatments targeting the neuroendocrine system for disorders of the skin and its appendages

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