Topical Calendula officinalis L. inhibits inflammatory pain through antioxidant, anti-inflammatory and peripheral opioid mechanisms

Garrido-Suárez, Bárbara B.; Garrido, Gabino; Menéndez, Addis Bellma; Merino, Nelsón; Valdés, Odalys; Paz, Nilia de la; Romero, Aylema; Delgado, Livan; Fernández, Miguel D.; Piñeros, Octavio; Hernández, René Delgado

doi:10.1016/j.joim.2022.10.002

Cited by 3 publications

(1 citation statement)

References 85 publications

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“…The plant's flowers and leaves can be used to make galenic medicines and pharmaceutical formulations that have a variety of pharmacological effects, most notably analgesic and anti-inflammatory properties. 100 An animal study verified calendula flower extract's ability to effectively reduce inflammation. NO, a pro-inflammatory substance produced by NO synthase and strongly secreted by innate immune cells during inflammation, is influenced by flower extract of C. officinalis.…”

Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 98%

A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Calendula officinalis Linn

Sapkota,

Kunwar

2024

Natural Product Communications

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Calendula officinalis Linn, known as pot marigold, is a plant that belongs to the Asteraceae family. Various online bibliographic databases namely, Google scholar, PubMed, SciFinder, and Web of Science were used for integrating information. Calendula officinalis is extensively used in Homoeopathic, Unani, and Ayurvedic system of medication as diaphoretic, analgesic, antiseptic, and anti-inflammatory agents and used to treat gynaecological issues, gastro-intestinal disorders, inflammations of oral and pharyangeal mucosa, eye problems, skin injuries and certain burns, poor eyesight, and menstrual irregularities. Several studies have shown that Calendula officinalis is a major source of diverse classes of bioactive compounds namely terpenoids, flavonoids, coumarines, quinones, and carotenoids. Various in vivo and in vitro assessment of Calendula officinalis's pharmacological activity suggest that the plant has antidiabetic, anti-inflammatory, anti-tumor, anticancer, and gastroprotective activity. This review compiles the information about pharmacological activities, traditional medicinal uses, and phytochemicals present in Calendula officinalis.

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Section: Anti-inflammatory and Analgesic Activitymentioning

confidence: 98%

A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Calendula officinalis Linn

Sapkota,

Kunwar

2024

Natural Product Communications

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Calendula in modern medicine: Advancements in wound healing and drug delivery applications

Ejiohuo,

Folami,

Maigoro

2024

European Journal of Medicinal Chemistry Reports

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An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L.

et al. 2023

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Calendula officinalis Linn. (CO) is a popular medicinal plant from the plant kingdom’s Asteraceae family that has been used for millennia. This plant contains flavonoids, triterpenoids, glycosides, saponins, carotenoids, volatile oil, amino acids, steroids, sterols, and quinines. These chemical constituents confer multifaceted biological effects such as anti-inflammatory, anti-cancer, antihelminthic, antidiabetes, wound healing, hepatoprotective, and antioxidant activities. Additionally, it is employed in cases of certain burns and gastrointestinal, gynecological, ocular, and skin conditions. In this review, we have discussed recent research from the last five years on the therapeutic applications of CO and emphasized its myriad capabilities as a traditional medicine. We have also elucidated CO’s molecular mechanisms and recent clinical studies. Overall, this review intends to summarize, fill in the gaps in the existing research, and provide a wealth of possibilities for researchers working to validate traditional claims and advance the safe and effective use of CO in treating various ailments.

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Topical Calendula officinalis L. inhibits inflammatory pain through antioxidant, anti-inflammatory and peripheral opioid mechanisms

Cited by 3 publications

References 85 publications

A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Calendula officinalis Linn

A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Calendula officinalis Linn

Calendula in modern medicine: Advancements in wound healing and drug delivery applications

An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L.

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