Topical capsaicin for pain in osteoarthritis: A literature review

Guedes, Vânia; Castro, João Paulo; Brito, Iva

doi:10.1016/j.reumae.2016.07.013

Cited by 21 publications

(16 citation statements)

References 13 publications

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“…56 Topical capsaicin has shown some efficacy in treating pain associated with knee OA. 57 One meta-analysis of RCTs concluded that topical NSAIDs and capsaicin may be equally efficacious for OA-associated pain relief, although none of the RCTs directly compared the two. 58 The major limitation of capsaicin is a patient-reported mild-to-moderate burning sensation with application that may decrease compliance.…”

Section: Topicalsmentioning

confidence: 99%

A practical approach to knee OA

Sprouse¹

2020

The Journal of Family Practice

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This review of the latest evidence on existing and emerging treatment options can help to inform your decision-making process as you endeavor to provide patients with pain relief. CASE u A 73-year-old woman presents to your clinic with 1 year of gradual-onset left knee pain. The pain is worse at the medial knee and at the beginning and end of the day, with some mild improvement after activity in the morning. The patient has already tried oral acetaminophen, an over-the-counter menthol cream, and a soft elastic knee brace, but these interventions have helped only minimally. On physical exam, there is no obvious deformity of the knee. There is a bit of small joint effusion without redness or warmth. There is mild tenderness to palpation of the medial joint line. Radiographic findings include osteophytes of the medial and lateral tibial plateaus and medial and lateral femoral condyles with mild joint-space narrowing of the medial compartment, consistent with mild osteoarthritis. How would you manage this patient's care? T he knee is the most common joint to be affected by osteoarthritis (OA) and accounts for the majority of the disease's total burden. 1 More than 19% of American adults ages ≥ 45 years have knee OA, 1,2 and more than half of the people with symptomatic knee OA in the United States are younger than 65 years of age. 3 Longer lifespan and increasing rates of obesity are thought to be driving the increasing prevalence of knee OA, although this remains debated. 1 Risk factors for knee OA are outlined in TABLE. 1,4-8 Diagnosis: Radiographs are helpful, not essential The diagnosis of knee OA is relatively straightforward. Gradual onset of knee joint pain is present most days, with pain worse after activity and better with rest. Patients are usually middleaged or older and/or have a distant history of knee joint injury.

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Section: Topicalsmentioning

confidence: 99%

A practical approach to knee OA

Sprouse¹

2020

The Journal of Family Practice

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“…В систематическом обзоре, в который вошли публикации 2004-2016 гг., отмечен хороший профиль безопасности и эффективности капсаицина в снижении боли при ОА СК, омартрозе, гонартрозе, коксартрозе [44]. Аппликации капсаицина сопровождаются жжением, которое достигает максимума к 1-й неделе лечения, после чего симптомы уменьшаются.…”

Section: капсаицинunclassified

Hand osteoarthritis: pathogenesis, diagnosis, and approaches to therapy

Шостак

Правдюк

Лила

et al. 2019

Sovremennaâ revmatologiâ

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Osteoarthritis (OA) is a widespread disease accompanied by persistent joint damage with obvious functional failure, which leads to early disability in patients. In OA, different groups of joints are involved in the pathological process. Hand joints are one of the classical sites of OA. The paper discusses the role of mechanical load, genetic factors, and sex hormone deficiency in the development of the disease. The treatment policy includes a set of non-pharmacological, pharmacological, and surgical methods.

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“…A systematic review of an RCT42 reported knee pain relief and functional outcomes improvement compared with a placebo (small-to-moderate effects).…”

Section: Pharmacological Optionsmentioning

confidence: 99%