Topical capsaicin for pain in osteoarthritis: A literature review

Guedes, Vânia; Castro, João Paulo; Brito, Iva

doi:10.1016/j.reuma.2016.07.008

Cited by 42 publications

(18 citation statements)

References 13 publications

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“…These findings are also consistent with previous studies on topical capsaicin where burning sensation and erythema were the most common adverse effects reported. [18][19][20]36 With continuous use of capsaicin, these side effects were reported to diminish and were attributed to continuous desensitization and neural depletion of substance P. 16,35 The results of the present study suggest that the community preparation of the Siling Labuyo liniment is comparable to the commercially prepared capsaicin creams studied in reviewed literature. The modest improvement in pain and functionality reported with the use of the capsaicin cream in literature is similar to the improvement seen with the use of the Siling Labuyo liniment in this study.…”

Section: Discussionsupporting

confidence: 52%

A Preliminary Study on the Safety, Efficacy and Acceptability of the Community Preparation of Siling Labuyo (Capsicum frutescens) Liniment in the Management of Knee Osteoarthritis in a Six-Week, Active-Controlled Community-Based Clinical Trial

Paterno¹,

Pangilinan²,

Arollado³

et al. 2019

Acta Med Philipp

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Objective. The study determined the safety, efficacy and acceptability of a Philippine community preparation of Siling Labuyo liniment in the management of knee osteoarthritis. Methods. A 6-week randomized, double-blind, active-controlled clinical trial was conducted in three municipalities of Cavite from 2017-2018. The municipalities were randomly assigned to either the control or experimental group, using a commercially available Diclofenac 1% gel as the control agent. Knee Injury and Osteoarthritis Outcome Score (KOOS) and Pain Visual Analogue Scale (VAS) were used to measure the outcomes. Results. Forty-seven participants completed the study. Statistically significant improvement (p<0.05) in pain relief, reduction of symptoms and increase in knee functionality was reported by participants in both the experimental and control groups. Across the dimensions measured, at least 30% improvement in scores was reported by the experimental group, and at least 40% by the control group. The difference was statistically not significant (p>0.05). Itching (13%), burning sensation (11%) and reddening of the skin (15%) were experienced in both the experimental and the active control groups. Conclusion. Use of the liniment led to a modest therapeutic effect and was well-tolerated by the participants.

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Section: Discussionsupporting

confidence: 52%

A Preliminary Study on the Safety, Efficacy and Acceptability of the Community Preparation of Siling Labuyo (Capsicum frutescens) Liniment in the Management of Knee Osteoarthritis in a Six-Week, Active-Controlled Community-Based Clinical Trial

Paterno¹,

Pangilinan²,

Arollado³

et al. 2019

Acta Med Philipp

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“…Reinnervation and sensation returned several weeks after treatment. Topical capsaicin products are currently used for chronic musculoskeletal and neuropathic pain (see reviews Guedes, Castro, & Brito, 2018; Üçeyler et al, 2014). Wound instillation of dilute capsaicin has been used preemptively to reduce post‐operative pain and opioid use.…”

Section: Introductionmentioning

confidence: 99%

Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats

Uhelski

McAdams

Johns

et al. 2020

European Journal of Pain

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Background Spontaneous pain after surgical incision is a significant problem for most post‐operative patients. Pain management that relies on opioids is hindered by numerous side effects, fuelling interest in non‐opioid alternatives and multimodal approaches. Subcutaneous capsaicin infiltration has shown potential for reducing post‐operative pain, but there are unanswered questions about safety and possible side effects. In adult rats, we characterized the analgesic effects of pre‐operative capsaicin infiltration into the skin prior to plantar incision and assessed wound healing and epidermal innervation. Methods The surgical site on the plantar surface of the rat hind paw was infiltrated with 1% capsaicin or vehicle 30 min or 1 week prior to surgical incision. Spontaneous and evoked pain behaviours were assessed. Digital images of incised hind paws were used to quantify the surface area of the wound after suture removal. Epidermal nerve fibre quantification was performed on peri‐incisional tissue biopsies. Results Intraplantar administration of capsaicin 30 min before surgical incision attenuated spontaneous pain behaviours, heat hyperalgesia, epidermal innervation, but it did not alter the rate of wound healing. Incisional pain hypersensitivity returned to baseline 2 weeks post‐incision, at a time when no recovery of epidermal innervation is observed. Conclusions Subcutaneous infiltration of capsaicin prior to surgical incision attenuated incision‐induced pain behaviours and reduced epidermal innervation around the incision site. The long‐lasting epidermal denervation by capsaicin had no impact in the rate of wound healing and recovery from pain behaviours. Significance Pre‐operative capsaicin infiltration attenuated spontaneous pain‐like behaviour and prevented the development of heat hyperalgesia following plantar skin incision. While capsaicin caused long‐lasting and widespread loss of epidermal and dermal nerve fibres, there was no measurable impact on the rate of wound healing. Pre‐ or intra‐operative infiltration of capsaicin into surgical sites could act as a safe prophylactic for post‐operative pain and reduce the need for opioids during recovery.

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“…Capsaicin has been reported as a chemopreventive, tumor suppressing, radiosensitizing, and anticancer agent in various cancer models [9,10,11]. Topical application of capsaicin is used to reduce pain or may represent an effective treatment to alleviate the symptoms of osteoarthritis when oral non-steroidal anti-inflammatory drugs are not used due to side effects [12]. Capsaicin binds to a subfamily of receptor called transient receptor potential cation channel subfamily V member 1 (TRPV1).…”

Section: Capsaicinmentioning

confidence: 99%

Role of Phytochemicals in Cancer Prevention

Ranjan

Ramachandran

Gupta

et al. 2019

IJMS

274

128

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The use of synthetic, natural, or biological agents to minimize the occurrence of cancer in healthy individuals is defined as cancer chemoprevention. Chemopreventive agents inhibit the development of cancer either by impeding DNA damage, which leads to malignancy or by reversing or blocking the division of premalignant cells with DNA damage. The benefit of this approach has been demonstrated in clinical trials of breast, prostate, and colon cancer. The continuous increase in cancer cases, failure of conventional chemotherapies to control cancer, and excessive toxicity of chemotherapies clearly demand an alternative approach. The first trial to show benefit of chemoprevention was undertaken in breast cancer patients with the use of tamoxifen, which demonstrated a significant decrease in invasive breast cancer. The success of using chemopreventive agents for protecting the high risk populations from cancer indicates that the strategy is rational and promising. Dietary components such as capsaicin, cucurbitacin B, isoflavones, catechins, lycopenes, benzyl isothiocyanate, phenethyl isothiocyanate, and piperlongumine have demonstrated inhibitory effects on cancer cells indicating that they may serve as chemopreventive agents. In this review, we have addressed the mechanism of chemopreventive and anticancer effects of several natural agents.

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Topical capsaicin for pain in osteoarthritis: A literature review

Cited by 42 publications

References 13 publications

A Preliminary Study on the Safety, Efficacy and Acceptability of the Community Preparation of Siling Labuyo (Capsicum frutescens) Liniment in the Management of Knee Osteoarthritis in a Six-Week, Active-Controlled Community-Based Clinical Trial

A Preliminary Study on the Safety, Efficacy and Acceptability of the Community Preparation of Siling Labuyo (Capsicum frutescens) Liniment in the Management of Knee Osteoarthritis in a Six-Week, Active-Controlled Community-Based Clinical Trial

Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats

Role of Phytochemicals in Cancer Prevention

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