Topical Ciclosporin in Nail Psoriasis

Psoriasis of the nail: Anatomy, pathology, clinical presentation, and a review of the literature on therapy

“…Similarly, topical cyclosporine also showed impressive clearing of nail pitting and onycholysis, but the lone study was based on the lesions of only one patient. 91 In general, topical therapies appear to be an easy and relatively effective form of treatment for nail psoriasis, especially with respect to subungual hyperkeratosis, but lack convincing evidence for other dystrophies. Even though the use of topical medications is safe and effective on specific nail dystrophies, there still remains a legitimate need for more wellcontrolled and well-documented studies within the literature.…”

Modulation of linear nail growth to treat diseases of the nail

“…In 1990, Tosti et al 70 reported clinical improvement in nail psoriasis following application of topical cyclosporine to the proximal nailfold for 3 months. Similarly, efficacy was demonstrated in a recent randomized placebo-controlled trial of topical cyclosporine.…”

Various pharmacological options are used to treat nail psoriasis, but choosing the best regimen is difficult

“…Dithranol may have antiproliferative and anti-inflammatory properties, and short contact treatment with the drug for 5 months appeared to be effective in treating psoriatic nail bed dystrophies and, to a lesser extent, matrix disease (table I), [10] although the local irritation and temporary nail staining associated with dithranol may not be acceptable to some patients. [12] Its efficacy has since been confirmed in a vehicle-controlled study [11] (table I). [12] Its efficacy has since been confirmed in a vehicle-controlled study [11] (table I).…”