Topical Cidofovir for Recalcitrant Verrucae in Individuals with Severe Combined Immunodeficiency After Hematopoietic Stem Cell Transplantation

Henrickson, Sarah E.; Treat, James R.

doi:10.1111/pde.12992

Cited by 13 publications

(10 citation statements)

References 5 publications

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“…Several case reports have been presented for PSV effects on viral warts [23][24][25][26][27] (Table 1) and other HPV-related diseases [28][29][30]. For example, one study found that topical treatment with a sinecatechins 10% ointment thrice daily for three weeks in a 34-year-old man with atopic dermatitis, who had not responded to 5-fluorouracil ointment, water filtered infrared A irradiation, and topical retinoids, resulted in a complete remission of all facial warts within 20 days [23].…”

Section: Case Eeports Of Psv Effects On Viral Warts and Other Hpv-related Diseasesmentioning

confidence: 99%

Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

et al. 2020

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Most cell-based and animal experiments have shown that green tea catechins (GTC) exhibit various health benefits. In human experimental and epidemiological studies, there are conflicting results, and more precise investigations are required. One of the most effective ways to prove beneficial health effects in humans might be clinical intervention studies. Polyphenon®E was developed as a standardized GTC preparation, which was approved by Food and Drug Administration of US in 2006 as a medication to treat genital warts (Veregen® or sinecatechins). Positive efficacy of Polyphenon®E/sinecatechins/Veregen® (PSV) on anogenital warts has been demonstrated in several epidemiological studies and there have been several case reports to show the clinical effectiveness of PSV. In addition, several studies have provided evidence to suggest that PSV is effective in other human papillomavirus (HPV)-related diseases, although some studies failed to show such effects. Since (−)-epigallocatechin gallate (EGCG) is the major component of PSV, the mechanism of the action of PSV might be deduced from that of EGCG. The microarray analysis of the biopsy samples from the patients suggested that apoptosis induction and the downregulation of inflammation are involved in the mechanism of the action of PSV in the clearance of anogenital warts. Cell-based and animal experiments using PSV also demonstrated effects similar to those elicited by EGCG, explaining how PSV works to induce apoptosis and exert anti-inflammatory actions in HPV-related diseases. Future studies would clarify what kinds of diseases respond effectively to PSV, showing health benefits of GTC and EGCG in humans.

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Section: Case Eeports Of Psv Effects On Viral Warts and Other Hpv-related Diseasesmentioning

confidence: 99%

Applications of a Standardized Green Tea Catechin Preparation for Viral Warts and Human Papilloma Virus-Related and Unrelated Cancers

et al. 2020

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“…HSCT can result in prompt eradication, though JAK3 mutations and common γ chain SCID can have significant warts post-HSCT, which may be in part due to poor NK cell function ( 64 ). Topical cidofovir has recently been shown in a case report to be effective in some of these patients ( 72 ). In one case, regression was observed after papillomavirus vaccination ( 61 ).…”

Section: Chronic Viral Skin Infections In Primary Immunodeficiencymentioning

confidence: 99%

Recurrent and Sustained Viral Infections in Primary Immunodeficiencies

2017

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Viral infections are commonplace and often innocuous. Nevertheless, within the population of patients with primary immunodeficiencies (PIDDs), viral infections can be the feature that drives a diagnostic evaluation or can be the most significant morbidity for the patient. This review is focused on the viral complications of PIDDs. It will focus on respiratory viruses, the most common type of viral infection in the general population. Children and adults with an increased frequency or severity of respiratory viral infections are often referred for an immunologic evaluation. The classic teaching is to investigate humoral function in people with recurrent sinopulmonary infections, but this is often interpreted to mean recurrent bacterial infections. Recurrent or very severe viral infections may also be a harbinger of a primary immunodeficiency as well. This review will also cover persistent cutaneous viral infections, systemic infections, central nervous system infections, and gastrointestinal infections. In each case, the specific viral infections may drive a diagnostic evaluation that is specific for that type of virus. This review also discusses the management of these infections, which can become problematic in patients with PIDDs.

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“…Preliminary studies have similarly demonstrated efficacy for extragenital warts . The use in children has been limited, with only three reports of treatment with sinecatechins ointment in the literature to date . In two‐thirds of these cases, warts resolved completely after thrice daily use of sinecatechins ointment for 8‐10 weeks.…”

Section: Introductionmentioning

confidence: 99%