Topical clobetasol propionate may not be safe for treating umbilical granuloma in infants

Aydın, Mustafa; Orman, Ayşen; Deveci, Uğur; Taşkın, Erdal

doi:10.1111/apa.12849

Cited by 11 publications

(10 citation statements)

References 2 publications

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“…Furthermore, burns in the skin have been reported after this treatment modality (Dhungel et al, 2008;Annapurna et al,2015;Hossain et al, 2010;Fiaz et al, 2017). Although local steroid treatment is recommended for UG treatment, it is not recommended for routine use in the treatment of UG because of their local and systemic side effects (Brodsgaard et al, 2015;Aydın et al, 2015). Surgical excision is another invasive method used for the treatment when a response cannot be obtained with other methods.…”

Section: Introductionmentioning

confidence: 99%

Table Salt is An Alternative to Silver Nitrate Cautery for the Treatment of Umbilical Granuloma: A Prospective Randomized Controlled Trial

2020

JSTR

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The aim of this prospective study explore a cheap and readily available alternative to silver nitrate cautery, with far-reaching implications for many populations with limited access to medical care. Seventy four patients were enrolled in this prospective randomized controlled study. Patients were divided in two groups of 37 patients each. A stick applicator of 75% silver nitrate was applied in first group by the pediatric surgeon in the outpatient clinic. The patients in the second group was applied a small amount of table salt granules twice a day for 3 days by the family members at home. In the first week after treatment, the same treatment was applied for the second time to the patients who presence of umbilical exudate in both groups. Response to treatment was evaluated in the second week. There were no statistically significant differences between the two groups in the first week and second week after treatment in regard to presence of umbilical exudate and complication (P>0,05). Table salt is a safe alternative to silver nitrate cautery in the treatment of umbilical granuloma.

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Section: Introductionmentioning

confidence: 99%

Table Salt is An Alternative to Silver Nitrate Cautery for the Treatment of Umbilical Granuloma: A Prospective Randomized Controlled Trial

2020

JSTR

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“…Therefore, the authors suggested use of clobetasol propionate cream as an alternative to silver nitrate. However, in Aydın et al [33], topical clobetasol propionate has been held for responsible in suppressing hypothalamic-pituitary-adrenal axis. So, they suggested use of it in children older than 12 years old.…”

Section: Other Treatment Optionsmentioning

confidence: 99%

Umbilical Granuloma: Modern Understanding of Etiopathogenesis, Diagnosis, and Management

Karagüzel¹,

Aldemir²

2016

JPNC

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Umbilical granuloma is a small swelling composed of granulation tissue at the base of the umbilicus. It is a relatively common problem in neonatal period, encountering after separation of the umbilical cord. The granuloma is thought to develop in response to subclinical infection or inadequate epithelialization of umbilical cord stump. The main clinical symptoms are umbilical discharge and swelling. Physical examination shows a small, moist, fragile and pinkish/red lesion at the umbilicus. Besides some benign soft tissue tumors, vitellin duct anomalies or urachal remnants should be considered in the differential diagnosis. The issue of what is the best treatment option is still controversial. Although silver nitrate application is the most common one among the actual treatment options, other therapeutic methods are also available. These include common salt application, topical antiseptics/antibiotics/steroids, ligation, excision, electrocautery, and cryotherapy. At the current practice, common salt application is suggested if silver nitrate cannot be used as the first option. In patients with treatmentresistant cases, excision should be done after ruling out other potential diseases. A detailed work-up is needed if the lesion has equivocal clinical characteristics or do not respond to therapeutic interventions mentioned above.

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“…Topical clobetasol propionate, however, has been found to suppress the hypothalamic-pituitary-adrenal axis. Hence, it has been suggested that it be used only in patients over 12 years of age [11]. Finally, surgical removal requires general anesthesia as well as an experienced physician, usually a surgeon, and sterile conditions and equipment [12].…”

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Treatment of umbilical granuloma in neonates

Nikolaevich¹,

Minaev²,

Vasilyevich³

et al. 2018

Medical news of the North Caucasus

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Medical news of north caucasus 2018. Vоl. 13. Iss. 3 U mbilical granuloma is the most common umbilical pathology in newborns and young children [1, 2], developing in about 1 in 500 births [3]. The umbilical granuloma is overgrown tissue that develops during the healing process of the navel, usually in response to a mild infection. It appears as a soft, pink or red lump and is often wet, oozing a small amount of clear or yellow fluid. Umbilical cord granulomas do not contain nerves and thus have no sensation [4]. The umbilical cord is usually separated within 7-10 days after delivery [5]. Normally, the granulation tissue of an absorbable umbilical stump of a newborn disappears by the second or third week of life. If present after this time, the persistent granuloma requires attention. Methods for treating umbilical granulomas include chemical cauterization with silver nitrate or copper sulfate, cryo-cauterization, electrical cautery, a double-ligature technique, and surgical excision. In addition, in 1972, Schmitt described the drying effect of table salt on umbilical granulomas [6].Our study aimed to evaluate the therapeutic effect of edible salt on umbilical granulomas in neonates. ЛЕЧЕНИЕ ФУНГУСаПУПКа У ГрУдНЫХ дЕТЕй ю. Н. Болотов, С. в. минаев, а. в. Качанов, Ф. в. доронин, а. С. Суханова, а. И. афанасова Ставропольский государственный медицинский университет, российская ФедерацияUmbilical granuloma is the most common umbilical abnormality in young infants and neonates. This prospective study was conducted on 21 infants (28-63 days old) with an umbilical granuloma. The treatment, performed in the patient's home, comprised application of common (edible) salt on the lesion twice a day for 5 days. Results were good in all cases. Thus, application of common salt for treating umbilical granulomas is simple and safe.Фунгус -одно из часто встречающихся заболеваний пупка у новорожденных и грудных детей. Было проведено проспективное исследование 21 ребенка в возрасте 28-63 дней, лечившихся амбулаторно. Лечение проводилось родителями дома путем аппликаций кристаллов столовой соли на фунгус под лейкопластырной наклейкой на 20 минут дважды в день, на протяжении 5 дней. У всех пациентов был получен хороший результат. Таким образом, использование предлагаемой методики показало ее эффективность и безопасность в лечении фунгуса пупка у грудных детей. Ключевые слова: фунгус пупка, дети, лечениеFor citation: Bolotov Iu. N., Minaev S. V., Kachanov A. Federation 2 s. V. ochapovsky regional clinical hospital № 1, Krasnodar, russian federation 3 city hospital № 4, sochi, russian federation 1 Кубанский государственный медицинский университет, Краснодар, российская Федерация 2 Научно-исследовательский институт -Краевая клиническая больница № 1 имени профессора С. в. очаповского, Краснодар, российская Федерация 3 Городская больница № 4, Сочи, российская Федерация 4 Ставропольский государственный медицинский университет, российская Федерация A comparative assessment of the original method of DTD for skin defects closure in the lower li...

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Topical clobetasol propionate may not be safe for treating umbilical granuloma in infants

Cited by 11 publications

References 2 publications

Table Salt is An Alternative to Silver Nitrate Cautery for the Treatment of Umbilical Granuloma: A Prospective Randomized Controlled Trial

Table Salt is An Alternative to Silver Nitrate Cautery for the Treatment of Umbilical Granuloma: A Prospective Randomized Controlled Trial

Umbilical Granuloma: Modern Understanding of Etiopathogenesis, Diagnosis, and Management

Treatment of umbilical granuloma in neonates

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