Topical cyclosporine 5% cream in Zoon's balanitis resistant to other therapies: A case report

Giorgio, Caterina M.; Briatico, Giulia; Licata, Gaetano; Babino, Graziella; Fulgione, Elisabetta; Ronchi, Andrea; Argenziano, Giuseppe

doi:10.1111/dth.14807

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Topical Cyc‐A has been prescribed in various mucocutaneous conditions 22 . Giorgio et al, 2021 23 administered 5% topical Cyc‐A cream in the treatment of a 46‐year‐old patient with Zoon's balanitis. Zoon's balanitis is also known as balanitis circumscripta plasmacellularis, and in this case was resistant to other therapies such as topical antimycotics and antibiotics.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the efficacy and safety of topical cyclosporine in dermatology

Sadeghi

Kalantari

Seirafianpour

et al. 2022

Dermatologic Therapy

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Cyclosporine-A (Cyc-A) was initially prescribed as systemic therapy for patients receiving solid organ transplants or in patients with graft versus host disease (GVHD). Topical Cyc-A is an ideal form of cyclosporine in the treatment of mucocutaneous disorders as it causes fewer systemic side effects and has more stable results than steroids; however, poor absorption through the skin makes the development of new formulations necessary to improve skin permeability. The aim of this study was to evaluate the efficacy and safety of topical Cyc-A in different dermatological conditions. A thorough systematic review was performed on PubMed/Medline, Embase, Scopus, and Web of Science databases as well as Google Scholar, and relevant studies from 2000 until January 3, 2022, were selected. The study was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA). Topical Cyc-A was observed to be an effective medication in the treatment of oral lichen planus, psoriasis, burning mouth syndrome, Pyoderma Gangrenosum, and Zoon's balanitis. Adverse side effects such as dysphagia, burning sensation, lips swelling, and gastrointestinal upset were reported following Cyc-A mouthwash use, whereas mild erythema, dryness, and fissuring of the skin were observed following the Cyc-A lipogel application. Topical Cyc-A was found to be a good alternative to traditional treatment regimens for immune-mediated mucocutaneous conditions. Cyc-A can be considered as a safe and efficient option in cases of long-term treatment as it does not have the same adverse effects of long-term steroids.

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Section: Resultsmentioning

confidence: 99%

A systematic review of the efficacy and safety of topical cyclosporine in dermatology

Sadeghi

Kalantari

Seirafianpour

et al. 2022

Dermatologic Therapy

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“…[ 31 32 ] Topical cyclosporine is the newest therapeutic option as observed by Giorgio CMR et al . [ 36 ] who used galenical cream with cyclosporine 5% twice a day to cure an erythematous plaque on glans in a 46-year-old male, non-responsive to antibiotics and antifungals. Improvement was observed in a span of 4 weeks.…”

Section: Discussionmentioning

confidence: 99%

Zoon’s Balanitis – Update of Clinical Spectrum and Management

Relhan,

Kumar,

Kaur

2024

Indian Journal of Dermatology

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Zoon’s balanitis or balanitis plasmacellularis circumscripta is a chronic inflammatory disorder of the genital mucosa that can affect both males and females (Zoon’s vulvitis). It is not a sexually transmitted disease but can still cause anxiety to the patients because of its chronic nature. Hence, proper diagnosis and early management are necessary. It is a clinical mimicker of other commoner genital dermatoses and is mostly a diagnosis of exclusion when other diseases have been ruled out. It is characterised by a well-demarcated shiny erythematous patch or plaque over the genital mucosa. Histopathological examination becomes necessary when we are unable to differentiate it from premalignant lesions. It reveals lozenge-shaped keratinocytes with siderophages, haemorrhages and variable plasma cell infiltrate in the dermis. Dermoscopy shows spermatozoa-like, convoluted vessels with structureless red orange areas. Response to topical therapy alone is not always satisfactory. However, lasers and surgical management can provide long-term remission.

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“…We read with interest the case ‘Topical Cyclosporine 5% Cream in Zoon's Balanitis Resistant To Other Therapies: A Case Report’ reported by our colleagues Giorgio et al 1 recently published in this journal.…”

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confidence: 99%

Reply to: Topical cyclosporine 5% cream in Zoon's balanitis resistant to other therapies: A case report

Watchorn

Helen

Kravvas

et al. 2021

Dermatologic Therapy

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Topical cyclosporine 5% cream in Zoon's balanitis resistant to other therapies: A case report

Cited by 5 publications

References 10 publications

A systematic review of the efficacy and safety of topical cyclosporine in dermatology

A systematic review of the efficacy and safety of topical cyclosporine in dermatology

Zoon’s Balanitis – Update of Clinical Spectrum and Management

Reply to: Topical cyclosporine 5% cream in Zoon's balanitis resistant to other therapies: A case report

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