Topical Delivery of Anti-sense Oligonucleotides Using Low-Frequency Sonophoresis

Tezel, Ahmet; Dokka, Sujatha; Kelly, Susan; Hardee, Gregory E.; Mitragotri, Samir

doi:10.1007/s11095-004-7674-6

Cited by 80 publications

(56 citation statements)

References 21 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Focusing on the NPs-assisted ultrasound as the aim of this review, a first study supporting the delivery of oligonucleotides by the application of LFS (20 kHz, 2.4 W/cm 2 , 50% duty cycle, 10 min) across the fullthickness pig skin was reported by Tezel et al [39]. Similarly, Tran et al delivered small interfering RNA loaded into cationic liposomes to melanocytic tumors present in skin to retard melanoma development.…”

Section: Sonophoresismentioning

confidence: 98%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

353

247

View full text Add to dashboard Cite

• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

show abstract

Section: Sonophoresismentioning

confidence: 98%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

353

247

View full text Add to dashboard Cite

show abstract

“…Sonophoresis has been used for a while in physical therapy clinics for the localized treatment of pain and other indications. Several research articles have also indicated the effectiveness of this technique to deliver peptides and proteins such as insulin (67)(68)(69)(70)(71), heparin (72), γ-interferon and erythropoietin (70) along with other hormones (73) and oligoneucleotides (74). However, the degree of enhancement in drug delivery is highly dependent on the physicochemical properties of the drug (75).…”

Section: Sonophoresis/phonophoresismentioning

confidence: 99%

Transdermal Delivery of Proteins

2011

View full text Add to dashboard Cite

Abstract. Transdermal delivery of peptides and proteins avoids the disadvantages associated with the invasive parenteral route of administration and other alternative routes such as the pulmonary and nasal routes. Since proteins have a large size and are hydrophilic in nature, they cannot permeate passively across the skin due to the stratum corneum which allows the transport of only small lipophilic drug molecules. Enhancement techniques such as chemical enhancers, iontophoresis, microneedles, electroporation, sonophoresis, thermal ablation, laser ablation, radiofrequency ablation and noninvasive jet injectors aid in the delivery of proteins by overcoming the skin barrier in different ways. In this review, these enhancement techniques that can enable the transdermal delivery of proteins are discussed, including a discussion of mechanisms, sterility requirements, and commercial development of products. Combination of enhancement techniques may result in a synergistic effect allowing increased protein delivery and these are also discussed.

show abstract

“…Heterogeneous penetration led to the formation of localized transport pathways, which occupied about 5% of the total exposed skin area. Tezel et al, 2004.…”

Section: Oligonucleotidsmentioning

confidence: 99%

Chemical and Physical Enhancers for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

2012

Pharmacology

View full text Add to dashboard Cite

Topical Delivery of Anti-sense Oligonucleotides Using Low-Frequency Sonophoresis

Abstract: These results show successful delivery of anti-sense oligonucleotides using low-frequency ultrasound.

Cited by 80 publications

References 21 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Transdermal Delivery of Proteins

Chemical and Physical Enhancers for Transdermal Drug Delivery

Contact Info

Product

Resources

About