Topical delivery of extracted curcumin as curcumin loaded spanlastics anti-aging gel: Optimization using experimental design and ex-vivo evaluation

El Hosary, Rania; Teaima, Mahmoud H.; El-Nabarawi, Mohamed; Yousry, Yousra; Eltahan, Mahmoud; Bakr, Ahmed; Aboelela, Hussein; Abdelmonem, Rehab; Nassif, Rafik M.

doi:10.1016/j.jsps.2023.101912

Cited by 3 publications

(1 citation statement)

References 45 publications

(49 reference statements)

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“…Curcumin, as a natural hydrophobic dissolves easily in substances like dimethyl sulfoxide, acetone, ethanol, and oils [136]. However, it does not demonstrate good permeability through skin [137].…”

Section: Anti-aging/angiogenesismentioning

confidence: 99%

Potential of Curcumin in the Management of Skin Diseases

Kasprzak-Drozd,

Niziński,

Hawrył

et al. 2024

IJMS

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Curcumin is a polyphenolic molecule derived from the rhizoma of Curcuma longa L. This compound has been used for centuries due to its anti-inflammatory, antioxidant, and antimicrobial properties. These make it ideal for preventing and treating skin inflammation, premature skin ageing, psoriasis, and acne. Additionally, it exhibits antiviral, antimutagenic, and antifungal effects. Curcumin provides protection against skin damage caused by prolonged exposure to UVB radiation. It reduces wound healing times and improves collagen deposition. Moreover, it increases fibroblast and vascular density in wounds. This review summarizes the available information on the therapeutic effect of curcumin in treating skin diseases. The results suggest that curcumin may be an inexpensive, well-tolerated, and effective agent for treating skin diseases. However, larger clinical trials are needed to confirm these observations due to limitations in its in vivo use, such as low bioavailability after oral administration and metabolism.

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Section: Anti-aging/angiogenesismentioning

confidence: 99%

Potential of Curcumin in the Management of Skin Diseases

Kasprzak-Drozd,

Niziński,

Hawrył

et al. 2024

IJMS

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Augmented glycerosomes as a promising approach against fungal ear infection: Optimization and microbiological, ex vivo and in vivo assessments

Ahmed,

Attia,

Saher

et al. 2024

International Journal of Pharmaceutics: X

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Overview of Spanlastics: A Groundbreaking Elastic Medication Delivery Device with Versatile Prospects for Administration via Various Routes

Kumar,

Rana,

Kukreti

et al. 2024

CPD

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When compared to the challenges associated with traditional dosage forms, medication delivery systems based on nanotechnology have been a huge boon. One such candidate for medication delivery is spanlastics, an elastic nanovesicle that can transport a diverse array of medicinal compounds. The use of spanlastics has been associated with an increase in interest in alternative administration methods. The non-ionic surfactant or surfactant blend is the main component of spanlastics. The purpose of this review was primarily to examine the potential of spanlastics as a delivery system for a variety of medication classes administered via diverse routes. Science Direct, Google Scholar, and Pubmed were utilized to search the academic literature for this review. Several studies have demonstrated that spanlastics greatly improve therapeutic effectiveness, increase medication absorption, and decrease drug toxicity. This paper provides a summary of the composition and structure of spanlastics along with their utility in the delivery of various therapeutic agents by adopting different routes. Additionally, it provides an overview of the numerous disorders that may be treated using drugs that are contained in spanlastic vesicles.

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Topical delivery of extracted curcumin as curcumin loaded spanlastics anti-aging gel: Optimization using experimental design and ex-vivo evaluation

Cited by 3 publications

References 45 publications

Potential of Curcumin in the Management of Skin Diseases

Potential of Curcumin in the Management of Skin Diseases

Augmented glycerosomes as a promising approach against fungal ear infection: Optimization and microbiological, ex vivo and in vivo assessments

Overview of Spanlastics: A Groundbreaking Elastic Medication Delivery Device with Versatile Prospects for Administration via Various Routes

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