Topical dose justification: benzoyl peroxide concentrations

Brandstetter, Andreas J.; Maibach, Howard I.

doi:10.3109/09546634.2011.641937

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…BPO has been a safe, cheap, and effective option for treating skin-based C acnes for many decades. 4 It penetrates the epidermis and deep sebaceous glands within the hair follicles and has a bactericidal effect on C acnes through a free radical mechanism without a risk of bacteria-specific resistance. BPO emollient foam (5.3%) has been shown to significantly reduce C acnes counts on the back by 1.9 log in 1 week and 2.1 log in 2 weeks, with reduced baseline after discontinued use.…”

Section: Discussionmentioning

confidence: 99%

“…Acne vulgaris caused by C acnes can be successfully treated clinically using benzoyl peroxide (BPO) solutions, which enhance follicular penetration of the sebaceous glands. 3,4,12 Consequently, BPO is a potentially promising presurgical skin treatment to decrease the C acnes burden and possibly decrease the risk of wound contamination and infection. However, the effect of BPO on C acnes in patients undergoing shoulder surgery compared with the effect of CHG is unknown.…”

mentioning

confidence: 99%

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Neer Award 2018: Benzoyl peroxide effectively decreases preoperative Cutibacterium acnes shoulder burden: a prospective randomized controlled trial

Kołakowski

Lai

Duvall

et al. 2018

Journal of Shoulder and Elbow Surgery

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Neer Award 2018: Benzoyl peroxide effectively decreases preoperative Cutibacterium acnes shoulder burden: a prospective randomized controlled trial

Kołakowski

Lai

Duvall

et al. 2018

Journal of Shoulder and Elbow Surgery

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“…The authors of this review compared different strengths (2.5%, 5% and 10%) of benzoyl peroxide . They searched PubMed, EMBASE and Science Citation Index, and included 10 studies overall.…”

Section: Treatments: Topicalmentioning

confidence: 99%

What's new in acne? An analysis of systematic reviews published in 2011-2012

Bhate

Williams

2014

Clin Exp Dermatol

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This review summarizes important clinical developments in acne vulgaris identified from 17 systematic reviews published between February 2011 and August 2012. Regarding causes, Demodex mites have been shown to be associated with both acne vulgaris and rosacea, although it is unclear if their eradication improves either disease. Some weak evidence has emerged that suggests a possible link between dairy produce and acne, which warrants further research. With reference to the effects of acne, there is good evidence that acne negatively affects quality of life, self-esteem and mood in adolescents. Acne is also associated with an increased risk of anxiety, depression and suicidal ideation, highlighting the importance of asking patients with acne directly about psychological issues in order to identify those who might benefit from early psychiatric support. Regarding treatment, there seems to be no additional benefit to using higher strengths of benzoyl peroxide, and lower strengths such as 2.5% have fewer side effects. Despite earlier concerns of increased mortality in those using topical tretinoin for skin cancer prevention, a systematic review on this topic has not found any convincing evidence of a link between such non-cutaneous events and once-daily application of 0.02-0.05% tretinoin. Combined oral contraceptives are of benefit in both inflammatory and non-inflammatory acne. Current surveys suggest that implementation of the pregnancy prevention programme for isotretinoin may not be stringent, and a high level of monitoring and audit is recommended. Ablative and non-ablative laser resurfacing for the treatment of acne scars may be beneficial, but further studies with a longer follow-up period are required.

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“…Adverse events included erythema and peeling skin where applied, but these were within tolerable limits. 13 According to studies 14 comparing the efficacy of BPO 10%, 5% and 2.5% and past published work reviews, 15 there is little difference in efficacy if the concentration is at least 2.5% and adverse events intensify at 10%. 14 As such, a concentration of 5% or less is advisable.…”

Section: Strength Of Recommendation: Amentioning

confidence: 99%

Japanese Dermatological Association Guidelines: Guidelines for the treatment of acne vulgaris 2017

Hayashi

Akamatsu

Iwatsuki

et al. 2018

The Journal of Dermatology

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The Guidelines for the Treatment of Acne Vulgaris of the Japanese Dermatological Association was first published in Japanese in 2008 and revised in 2016 and 2017. These guidelines (GL) indicate the standard acne treatments in Japan and address pharmaceutical drugs and treatments applicable or in use in Japan. In these GL, the strength of the recommendation is based on clinical evidences as well as availability in Japanese medical institutions. In the 2016 and 2017 GL, some of the clinical questions were revised, and other questions were added in accordance with approval of topical medicines containing benzoyl peroxide (BPO). Rather than monotherapies of antibiotics, the 2017 GL more strongly recommend combination therapies, especially fixed-dose combination gels including BPO in the aspects of pharmacological actions and compliance in the acute inflammatory phase to achieve earlier and better improvements. The 2017 GL also indicate to limit the antimicrobial treatments for the acute inflammatory phase up to approximately 3 months and recommend BPO, adapalene, and a fixed-dose combination gel of 0.1% adapalene and 2.5% BPO for the maintenance phase to avoid the emergence of antimicrobial-resistant Propionibacterium acnes. The 2017 GL also discuss rosacea, which requires discrimination from acne and a different treatment plan.

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Topical dose justification: benzoyl peroxide concentrations

Abstract: The extent of free fatty acids and the percutaneous penetration of BPO may not play a critical role in acne vulgaris.

Cited by 11 publications

References 6 publications

Neer Award 2018: Benzoyl peroxide effectively decreases preoperative Cutibacterium acnes shoulder burden: a prospective randomized controlled trial

Neer Award 2018: Benzoyl peroxide effectively decreases preoperative Cutibacterium acnes shoulder burden: a prospective randomized controlled trial

What's new in acne? An analysis of systematic reviews published in 2011-2012

Japanese Dermatological Association Guidelines: Guidelines for the treatment of acne vulgaris 2017

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