Topical erythromycin and zinc therapy for acne

Schachner, Lawrence A.; Eaglstein, William; Kittles, Carol; Mertza, Patricia

doi:10.1016/0190-9622(90)70034-f

Cited by 34 publications

(11 citation statements)

References 21 publications

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“…This study has proved that erythromycin-zinc complex was highly effective in treatment of acne vulgaris, act earlier and much more effective than erythromycin gel alone. These results are comparable to other studies in which the treatment with Zineryt lotion was found to be more effective than with 2% erythromycin [16], clindamycin lotion [17] and placebo [18,19] as regards the reduction in number of the acne lesions and the severity grade of the acne. There was a significant decrease (77.9%) in inflammatory lesions (papules and pustules) shown for the erythromycin/zinc treatment group at week 8.…”

Section: Resultssupporting

confidence: 81%

Topical erythromycin-zinc acetate complex lotion versus topical erythromycin gel in treatment of mild to moderate acne vulgaris

Al-Hamamy¹,

Sharquie²,

Noaimi³

et al. 2014

Our Dermatol Online

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Introduction: Topical antibiotics are the main step in the treatment of mild to moderate acne vulgaris. Erythromycin is one of the effective topical therapies for this disease. Zinc sulfate 5% solution was reported to be effective in treatment of acne vulgaris and rosacea. Aim: To compare the effectiveness and side effects of topical erythromycin in combination with zinc and erythromycin alone in treatment of mild to moderate acne vulgaris. Material and Methods: This single, blind, therapeutic, comparative study was done in the Department of Dermatology -Baghdad Teaching Hospital, Baghdad, Iraq; from May 2012 -August 2013.Scoring of acne was carried out and the patients were examined every two weeks for 10 weeks of treatment. One month after stopping drugs, patients were evaluated for drug complications and disease recurrence. Eighty patients fulfilling enrollment criteria were included in this study. Patients were divided into two groups: Group A (40 patients) treated twice daily with topical erythromycin-zinc complex lotion and Group B (40 patients) treated twice daily with topical 2% erythromycin gel. Results: Both topical erythromycin-zinc lotion and erythromycin gel were statistically an effective therapy starting after 6 weeks treatment and up to 4 weeks after stopping treatment. Erythromycin-zinc lotion was more effective and act earlier than erythromycin gel starting from 4 weeks of therapy till the end of treatment (after 10 week) and even after 4 weeks after stopping the treatment (p value <0.0001). Conclusions: Erythromycin-zinc complex lotion was an effective and well tolerated topical therapy for mild to moderate inflammatory acne vulgaris and was more effective than erythromycin gel alone.

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Section: Resultssupporting

confidence: 81%

Topical erythromycin-zinc acetate complex lotion versus topical erythromycin gel in treatment of mild to moderate acne vulgaris

Al-Hamamy¹,

Sharquie²,

Noaimi³

et al. 2014

Our Dermatol Online

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“…Of these, the combination of 4% erythromycin with 1.2% zinc acetate has proved its efficacy [3,4]. The beneficial effect of the zinc supplementation has been ascribed to four mechanisms including: (a) modulation of epithelial differentiation, either directly or through the vitamin A retinol-binding protein metabolism; (b) anti-inflammatory effects; (c) antibacterial effects; and (d) anti-androgen activity [5][6][7][8][9].…”

mentioning

confidence: 99%

A double-blind controlled evaluation of the sebosuppressive activity of topical erythromycin-zinc complex

Piérard-Franchimont

Goffin

Visser

et al. 1995

Eur J Clin Pharmacol

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In a double-blind randomised study, 14 volunteers applied 4% erythromycin plus 1.2% zinc (Zineryt lotion) and 4% erythromycin lotions, each on half of the forehead twice daily for 3 months. The sebum output was evaluated at 3-week intervals using the photometric and the lipid-sensitive film methods. Evaluations of casual level (CL) and sebum excretion rate (SER) were made with a Sebumeter, and total area of lipid spots (TAS) was measured on Sebutapes. Compared to baseline values, the formulation of the erythromycin-zinc complex induced significant reductions in SER after 6 and 9 weeks, and in CL and TAS at 3, 6, 9 and 12 weeks. The mean reduction in TAS was over 20% for four successive 1-h samplings on completion of the study. Significant reductions in CL, SER and TAS were observed for the erythromycin-zinc formulation compared to the control lotion at 6 and 9 weeks, and also at 3 weeks for SER and TAS, and at 12 weeks for CL and TAS. This study indicates that sebum output is significantly reduced by the erythromycin-zinc complex. This reduction is theoretically beneficial for the acneic patient.

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“…Allerdings unterschied sich die klinische Wirksamkeit einer Erythromycin 4 %‐Zinkacetat 1,2 %‐Kombination nicht von der Wirksamkeit von Erythromycin 4 % alleine [21] (Empfehlungsgrad B, Evidenzstufe 2b, n = 45) und verhinderte auch nicht das Auftreten von Erythromycin‐resistenten Propionibakterien unter Therapie. Die Kombination aus 4 % Erythromycin und 1,2 % Zinkacetat erwies sich in weiteren Studien zwar als wirksam, eine Kontrollgruppe mit Erythromycin alleine, die zur Beurteilung des Anteils von Zinkacetat am Behandlungserfolg erforderlich ist, fehlte jedoch entweder [22, 23] oder ist aufgrund einer geringeren Erythromycin‐Konzentration (2 %) und Unterschieden in der Grundlage schwer einzuschätzen [24].…”

Section: Zinkunclassified

Ergänzende Verfahren in der Aknetherapie

Degitz

Plewig

2005

J Deutsche Derma Gesell

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The mainstays of modern acne therapy include comedolytic, antimicrobial, and anti-inflammatory substances, as well as antiandrogens. Additionally, traditional or newly developed therapeutic approaches may be considered, including pharmacologic (dapsone, zinc) and physical measures (phototherapy, photodynamic therapy, comedone extraction, abrasives). This article reviews such adjunctive therapies with regard to efficacy and their roles in acne therapy.

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Topical erythromycin and zinc therapy for acne

Cited by 34 publications

References 21 publications

Topical erythromycin-zinc acetate complex lotion versus topical erythromycin gel in treatment of mild to moderate acne vulgaris

Topical erythromycin-zinc acetate complex lotion versus topical erythromycin gel in treatment of mild to moderate acne vulgaris

A double-blind controlled evaluation of the sebosuppressive activity of topical erythromycin-zinc complex

Ergänzende Verfahren in der Aknetherapie

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