Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats

Sarwa, Khomendra Kumar; Rudrapal, Mithun; Mazumder, Bhaskar

doi:10.3109/10717544.2013.861041

Cited by 34 publications

(8 citation statements)

References 26 publications

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“…These are also employed for antiinflammatory (64,65), anti-psoriatic (66) and antimicrobial therapeutics (67). Recent research has focused on binary ethosomes that contain polyols (such as propylene glycol) in addition to alcohol and water inside the ethosome core.…”

Section: Ethosomesmentioning

confidence: 99%

Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications

et al. 2014

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-Liposomes are lipid based vesicular systems that offer novel platform for versatile drug delivery to target cell. Liposomes were first reported by Bangham and his co-workers in 1964 (1). Since then, liposomes have undergone extensive research with the prime aim to optimize encapsulation, stability, circulation time and target specific drug delivery. Manipulation of a liposome's lipid bilayer and surface decoration with selective ligands has transformed conventional liposomes into adaptable and multifunctional liposomes. Development of liposomes with target specificity provide the prospect of safe and effective therapy for challenging clinical applications. Bioresponsive liposomes offer the opportunity to release payload in response to tissue specific microenvironment. Incorporation of novel natural and synthetic materials has extended their application from stable formulations to controlled release targeted drug delivery systems. Integration and optimization of multiple features into one system revolutionized research in the field of cancer, gene therapy, immunotherapy and infectious diseases. After 50 years since the first publication, this review is aimed to highlight next generation of liposomes, their preparation methods and progress in clinical applications.

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Section: Ethosomesmentioning

confidence: 99%

Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications

et al. 2014

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“…Then, the skin was mounted onto a Franz diffusion cell (Shanghai Kai Science and Technology Trade Co., Ltd, People's Republic of China). The area of the rat skin subjected to different capsaicin preparations in the donor chamber was 2.83 cm 2 , and the volume of the receiver fluid was 6.8 mL. Tested formulations equaling 1 mg capsaicin were applied evenly on the skin surface.…”

Section: In Vitro Penetration Of Capsaicin-based Formulationsmentioning

confidence: 99%

“…1,6,7 Furthermore, capsaicin is used in other topical therapies for inflammatory diseases such as rheumatism. 2,8 The time duration of capsaicin in the blood is rather short. The bioavailability of oral administration in humans has been reported through the following pharmacokinetic Topical capsaicin formulations, such as low-concentration patches, lotions, and creams, have been accessible for daily skin application in most countries for many years.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5] Topical capsaicin acts in the skin to reduce pain and diminish cutaneous hypersensitivity by a process best described as the "defunctionalization" of nociceptor fibers. Defunctionalization can be achieved by repeated applications of capsaicin, which can render a loss of responsiveness in patients to a wide range of noxious stimuli.…”

Section: Introductionmentioning

confidence: 99%

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Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation

Wang¹,

Gao²,

Niu³

et al. 2017

IJN

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Capsaicin has been used in clinical applications for the treatment of pain disorders and inflammatory diseases. Given the strong pungency and high oil/water partition coefficient of capsaicin, capsaicin-loaded nanolipoidal carriers (NLCs) were designed to increase permeation and achieve the analgesic, anti-inflammatory effect with lower skin irritation. Capsaicin-loaded NLCs were prepared and later optimized by the Box–Behnken design. The physicochemical characterizations, morphology, and encapsulation of the capsaicin-loaded NLCs were subsequently confirmed. Capsaicin-loaded NLCs and capsaicin-loaded NLCs gel exhibited sustained release and no cytotoxicity properties. Also, they could significantly enhance the penetration amount, permeation flux, and skin retention amounts of capsaicin due to the application of NLCs. To study the topical permeation mechanism of capsaicin, 3,3′-dioctadecyloxacarbocyanine perchlorate (Dio) was used as a fluorescent dye. Dio-loaded NLCs and Dio-loaded NLCs gel could effectively deliver Dio up to a skin depth of 260 and 210 μm, respectively, primarily through the appendage route on the basis of version skin sections compared with Dio solution, which only delivered Dio up to 150 μm. In vivo therapeutic experiments demonstrated that capsaicin-loaded NLCs and capsaicin-loaded NLCs gel could improve the pain threshold in a dose-dependent manner and inhibit inflammation, primarily by reducing the prostaglandin E2 levels in the tissue compared with capsaicin cream and capsaicin solution. Meanwhile, skin irritation was reduced, indicating that application of NLCs could decrease the irritation caused by capsaicin. Overall, NLCs may be a potential carrier for topical delivery of capsaicin for useful pain and inflammation therapy.

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“…The ethosomal formulation of topically administered capsaicin was evaluated for bio-efficacy in arthritic rats. The results revealed a significant reduction of rat paw edema along with promising antinociceptive action [ 68 ]. No predictable signs of toxicity such as skin irritation were observed.…”

Section: Anti-ra Activity Of Lipid-based Nanoparticlesmentioning

confidence: 99%

Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis

et al. 2018

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Rheumatoid arthritis (RA), a chronic and joint-related autoimmune disease, results in immune dysfunction and destruction of joints and cartilages. Small molecules and biological therapies have been applied in a wide variety of inflammatory disorders, but their utility as a therapeutic agent is limited by poor absorption, rapid metabolism, and serious side effects. To improve these limitations, nanoparticles, which are capable of encapsulating and protecting drugs from degradation before they reach the target site in vivo, may serve as drug delivery systems. The present research proposes a platform for different lipid nanoparticle approaches for RA therapy, taking advantage of the newly emerging field of lipid nanoparticles to develop a targeted theranostic system for application in the treatment of RA. This review aims to present the recent major application of lipid nanoparticles that provide a biocompatible and biodegradable delivery system to effectively improve RA targeting over free drugs via the presentation of tissue-specific targeting of ligand-controlled drug release by modulating nanoparticle composition.

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Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats

Cited by 34 publications

References 26 publications

Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications

Liposomal Drug Delivery: A Versatile Platform for Challenging Clinical Applications

Capsaicin-loaded nanolipoidal carriers for topical application: design, characterization, and in vitro/in vivo evaluation

Lipid-Based Nanoparticles as a Potential Delivery Approach in the Treatment of Rheumatoid Arthritis

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