Topical formulations containing aptamer-functionalized nanocapsules loaded with 5-fluorouracil - An innovative concept for the skin cancer therapy

Raţă, Delia Mihaela; Cadinoiu, Anca Niculina; Atanase, Leonard Ionuţ; Popa, Marcel; Mihai, Cosmin Teodor; Solcan, Carmen; Ochiuz, Lăcrămioara; Vochița, Gabriela

doi:10.1016/j.msec.2020.111591

Cited by 72 publications

(36 citation statements)

References 34 publications

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“…One of the best targeting ligands are monoclonal scFv antibodies fragments (single chain variable fragments), which, due to their relatively small size, higher (as compared to other types of ligands) binding specificity as well as the lack of complement activating region and Fc domain (which directly translates into a reduction in the immunogenicity of the modified nanocapsules) [8][9][10][11], are increasingly used to functionalize nanocarriers. Moreover, the aptamer-functionalized nanocapsules show a good compatibility with the bloodstream and do not have a cytotoxic effect [5,6]. In conclusion, nanotechnology-based therapeutic methods provide unusual control over behaviour of the drug in the body, thus providing the possibility of targeted treatment.…”

Section: Introductionmentioning

confidence: 92%

“…The main advantages of nanocarriers are their sub-cellular dimensions and tissue-cellular biocompatibility. The improvement of the compatibility of lipophilic, poorly water-soluble or even water-insoluble active compounds or increased drug permeability and absorption has been shown for various nanoformulations [3][4][5][6]. Drug encapsulation extends the duration of its action, protecting against rapid uptake and degradation, and by controlling the released dose it allows for maintaining concentration of the drug at the level of the required therapeutic concentration.…”

Section: Introductionmentioning

confidence: 99%

“…Drug encapsulation extends the duration of its action, protecting against rapid uptake and degradation, and by controlling the released dose it allows for maintaining concentration of the drug at the level of the required therapeutic concentration. Thus, such a strategy allows for reducing the size and frequency of doses [4][5][6][7]. In addition, the appropriate functionalization of the surface of the nanocarrier enables so-called "intelligent targeting", i.e., release of the drug at the appropriate destination [5,6,8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, such a strategy allows for reducing the size and frequency of doses [4][5][6][7]. In addition, the appropriate functionalization of the surface of the nanocarrier enables so-called "intelligent targeting", i.e., release of the drug at the appropriate destination [5,6,8,9]. Thanks to this, nanotherapeutics have the ability to "perform complex operations" in the right place at the right time in the patient's body, contrasting with previously developed preparations, whose greatest weakness has been non-selectivity.…”

Section: Introductionmentioning

confidence: 99%

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Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D2-Serotonin 5-HT1A Heteromers

Łukasiewicz

2021

Polymers

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Clozapine, the second generation antipsychotic drug, is one of the prominent compounds used for treatment of schizophrenia. Unfortunately, use of this drug is still limited due to serious side effects connected to its unspecific and non-selective action. Nevertheless, clozapine still remains the first-choice drug for the situation of drug-resistance schizophrenia. Development of the new strategy of clozapine delivery into well-defined parts of the brain has been a great challenge for modern science. In the present paper we focus on the presentation of a new nanocarrier for clozapine and its use for targeted transport, enabling its interaction with the dopamine D2 and serotonin 5-HT1A heteromers (D2-5-HT1A) in the brain tissue. Clozapine polymeric nanocapsules (CLO-NCs) were prepared using anionic surfactant AOT (sodium docusate) as an emulsifier, and bio-compatible polyelectrolytes such as: poly-L-glutamic acid (PGA) and poly-L-lysine (PLL). Outer layer of the carrier was grafted by polyethylene glycol (PEG). Several variants of nanocarriers containing the antipsychotic varying in physicochemical parameters were tested. This kind of approach may enable the availability and safety of the drug, improve the selectivity of its action, and finally increase effectiveness of schizophrenia therapy. Moreover, the purpose of the manuscript is to cover a wide scope of the issues, which should be considered while designing a novel means for drug delivery. It is important to determine the interactions of a new nanocarrier with many cell components on various cellular levels in order to be sure that the new nanocarrier will be safe and won’t cause undesired effects for a patient.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D2-Serotonin 5-HT1A Heteromers

Łukasiewicz

2021

Polymers

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“…The in vitro cell viability, targeting capability, and apoptotic effects of liposomes on the human dermal fibroblasts and on BCC cell lines were also evaluated. The results indicated that the functionalized liposomes, as nanocapsules [47] are more efficient as nanocarriers than the non-functionalized ones.…”

Section: Vesicular Systemsmentioning

confidence: 98%

Recent Advances in Nanotechnology for the Treatment of Melanoma

et al. 2021

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Melanoma is one of the most aggressive forms of skin cancer, with few possibilities for therapeutic approaches, due to its multi-drug resistance and, consequently, low survival rate for patients. Conventional therapies for treatment melanoma include radiotherapy, chemotherapy, targeted therapy, and immunotherapy, which have various side effects. For this reason, in recent years, pharmaceutical and biomedical research has focused on new sito-specific alternative therapeutic strategies. In this regard, nanotechnology offers numerous benefits which could improve the life expectancy of melanoma patients with very low adverse effects. This review aims to examine the latest advances in nanotechnology as an innovative strategy for treating melanoma. In particular, the use of different types of nanoparticles, such as vesicles, polymers, metal-based, carbon nanotubes, dendrimers, solid lipid, microneedles, and their combination with immunotherapies and vaccines will be discussed.

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Targeted Anticancer Drug Delivery Using Chitosan, Carbon Quantum Dots, and Aptamers to Deliver Ganoderic Acid and 5‐Fluorouracil

Mazandarani,

Taravati,

Mohammadnejad

et al. 2023

Chemistry & Biodiversity

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Breast cancer is a deadly disease that usually affects women. The nano‐drug delivery system's ligand‐functionalized nanoparticles have great cancer‐treatment potential. This study developed a potential method for drug loading and sustained release of breast cancer model medications 5‐fluorouracil (5‐FU) and Ganoderic acid (GA). CS/Apt/COQ NPs were produced. FT‐IR, XRD, DLS, zeta potentiometer, and SEM analyzed NP's chemical structure, particle size, and shape. In vitro MTT experiments examined MCF‐7 cell viability. Real‐time PCR quantified cell apoptosis. XRD and FTIR showed nanocarrier generation, crystalline structure, and molecular interactions. DLS indicated that nanocarriers contain 250.6 nm NPs with PDI 0.057. Zeta potential and SEM indicated their spherical shape and +37.8 mV surface charge. pH 5.4 released most 5‐FU and GA in 48 h. 5‐FU entrapment efficiency was 84.7 ± 5.2 and GA 80.2% ± 2.3. The 5‐FU‐GA‐CS‐CQD‐Apt group killed the most MCF‐7 cells, 57.9%. 5‐FU and GA in CS‐CQD‐Apt increased flow cytometry‐induced apoptosis. 5‐FU‐GA‐CS‐CQD‐Apt increased Caspase 9 and decreased Bcl2. Thus, pH‐sensitive NPs may release 5‐FU and GA to treat breast cancer.

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Topical formulations containing aptamer-functionalized nanocapsules loaded with 5-fluorouracil - An innovative concept for the skin cancer therapy

Cited by 72 publications

References 34 publications

Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D2-Serotonin 5-HT1A Heteromers

Development of a New Polymeric Nanocarrier Dedicated to Controlled Clozapine Delivery at the Dopamine D2-Serotonin 5-HT1A Heteromers

Recent Advances in Nanotechnology for the Treatment of Melanoma

Targeted Anticancer Drug Delivery Using Chitosan, Carbon Quantum Dots, and Aptamers to Deliver Ganoderic Acid and 5‐Fluorouracil

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