2016
DOI: 10.1002/ejp.971
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Topical gabapentin gel alleviates allodynia and hyperalgesia in the chronic sciatic nerve constriction injury neuropathic pain model

Abstract: Systemic gabapentin neuropathic pain management carries side-effects ostensibly preventable by localized therapy. This study validates the effectiveness potential of a topical gabapentin gel against an extensive range of nociceptive stimulus modalities utilizing the chronic constriction injury-induced neuropathic pain model.

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Cited by 45 publications
(51 citation statements)
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“…The constriction of nerve was minimal and was immediately stopped until a brief twitch was observed. An identical operation was performed, except that the sciatic nerve was not ligated in the sham-operated animals [70]. …”
Section: Methodsmentioning
confidence: 99%
“…The constriction of nerve was minimal and was immediately stopped until a brief twitch was observed. An identical operation was performed, except that the sciatic nerve was not ligated in the sham-operated animals [70]. …”
Section: Methodsmentioning
confidence: 99%
“…We recently noted that GBP is able to permeate TRPV1 channels activated by capsaicin, and this led to increased effectiveness (Biggs et al, 2015). Perhaps topical application of GBP (Shahid et al, 2017) combined with a TLR5 agonist such as flagellin (Xu et al, 2015) may facilitate its access to a2d-1 and thereby increase its effectiveness in the clinic.…”
Section: B Improving Gabapeninoid Effectivenessmentioning
confidence: 99%
“…GBP effectiveness was also increased in Xenopus oocytes when the system-L-neutral amino acid transporter was coexpressed with HVA-Ca 2+ channels (Hendrich et al, 2008). Additional support for an intracellular site of action comes from the observation that GBP application ipsilateral to CCI alleviates allodynia and hyperalgesia, whereas contralateral application does not (Shahid et al, 2017).…”
mentioning
confidence: 98%
“…[8] It acts in synergy with morphine and has a preemptive effect as well. [9] Several randomized controlled trials (RCT) have compared gabapentin with control groups.…”
Section: Introductionmentioning
confidence: 99%