Topical gels of lidocaine HCl using cashew gum and Carbopol 940: Preparation and in vitro skin permeation

Das, B. Krishna; Nayak, Amit Kumar; Nanda, Upendranath

doi:10.1016/j.ijbiomac.2013.09.049

Cited by 105 publications

(35 citation statements)

References 23 publications

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“…pHs of formulated 4 % lidocaine HCl gels were determined using a pH meter (Systronics Instruments, India) by inserting glass electrode into the gel, completely [22].…”

Section: Ph Determinationmentioning

confidence: 99%

“…The Franz diffusion cell comprises 2 chambers: the donor chamber and the receptor chamber [22]. The diffusion area of the Franz diffusion cell was 0.79 cm2.…”

Section: Ex Vivo Skin Permeation Experiments Of 4 % Lidocaine Hcl Gelsmentioning

confidence: 99%

“…These benefits favour the topical delivery of lidocaine for local action. In the previous literature, a few topical formulations of lidocaine are reported [18][19][20][21][22]. In the current research, we made an attempt to prepare 4 % lidocaine HCl topical gels of using cashew bark exudate gum.…”

Section: Introductionmentioning

confidence: 99%

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Use of Cashew Bark Exudate Gum in the Preparation of 4 % Lidocaine HCL Topical Gels

Hasnain

Rishishwar

Ali

2017

Int J Pharm Pharm Sci

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Objective: The objective of the current work was to prepare and evaluate ex vivo skin permeation of cashew bark exudate gum based 4 % lidocaine HCl topical gels.Methods: In the current work, 4 % lidocaine HCl topical gels were prepared by using different concentrations of cashew bark exudate gum, HPMC K4M, lidocaine HCl, methyl paraben (as preservative) and glycerin (as plasticizer). The formulated topical gels were evaluated for pH, viscosity, and ex vivo skin permeation through excised porcine ear skin membrane. Results:The pHs of these formulated 4 % lidocaine HCl topical gels were found within the range of 6.04±0.02 to 6.52±0.04; whereas, the viscosities were measured within the range, 4.38±0.02 x 10 6 to 4.74±0.04 x 10 6 cps. Sustained ex vivo permeation of lidocaine was measured over 7 h. Highest ex vivo permeation flux was measured when 0.1 % menthol was incorporated as a permeation enhancer. It was also higher than that of the marketed 4 % lidocaine HCl topical gel. The stability study by freeze thaw cycle method revealed physically stable gels without the occurrence of syneresis. Conclusion:The results clearly indicate a promising potential of the use of cashew bark exudate gum as a gelling material with HPMC K4M to prepare 4 % lidocaine HCl topical gels of good skin permeation capability.

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“…pHs of formulated 4 % lidocaine HCl gels were determined using a pH meter (Systronics Instruments, India) by inserting glass electrode into the gel, completely [22].…”

Section: Ph Determinationmentioning

confidence: 99%

“…The Franz diffusion cell comprises 2 chambers: the donor chamber and the receptor chamber [22]. The diffusion area of the Franz diffusion cell was 0.79 cm2.…”

Section: Ex Vivo Skin Permeation Experiments Of 4 % Lidocaine Hcl Gelsmentioning

confidence: 99%

See 1 more Smart Citation

Use of Cashew Bark Exudate Gum in the Preparation of 4 % Lidocaine HCL Topical Gels

Hasnain

Rishishwar

Ali

2017

Int J Pharm Pharm Sci

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“…The anomalous diffusion mechanism describes both diffusioncontrolled, and swelling-controlled drug permeation. 24 …”

Section: Ex Vivo Permeationmentioning

confidence: 99%

Buccal patches of atenolol formulated using fenugreek (Trigonella foenum-graecum L.) seed mucilage

Adhikari¹,

Panda²

2017

Polim. Med.

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“…The drug permeated or retainerd [34][35][36][37] through the skin (mg cm -2 ) using franz diffusion was calculated. Drug flux (permeation rate) at steady state (Jss) was calculated by dividing the slope of the graph linear portion with the diffusion cell area (mg cm -2 h -1).…”

Section: Permeation Data Analysismentioning

confidence: 99%

Design Development and Evaluation of Topical Microemulsion

Muzaffar¹,

Singh²

2017

Int. Res. J. Pharm.

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A microemulsion based gel was designed for the topical and targeted delivery of sertaconazole nitrate for the treatment of su perficial fungal infection. The microemulsion region was obtained using a ternary diagram, different ratio of oil and Smix were used. The microemulsion of sertaconazole containing 2% (w/w) of sertaconazole, 6.67% (w/w) of oil phase (Eugenol+Oleic acid 1:1), 60.18% (w/w) of surfactant mixture 2:1 ratio (Tween-80 and Transcutol-P) and 33.15% (w/w) with distilled water. The prepared microemulsion gel and commercial cream of sertaconazole were evaluated for in-vitro and ex-vivo studies. The highest drug retention was achieved with Tween 80 and Transcutol P (T80TC45) when the optimized formulation was converted to a gel. The designed formulation MG2 was safe to be used over the skin as the PDI=0 when compared with commercial cream and MG1. The optimized formulation also posse's anti-inflammatory activity. The average zone of inhibition of MG2 was (23.19 ± 0.478) which was more than the commercial cream (15.34 ± 0.382) or MG1 (17.78 ± 0.715). Candida albicans which may be due to better permeation and retention effect of microemulsion gel 2. The MG2 was found to be stable after six month. The results obtained in this research from in vitro and in vivo data it can be concluded that the developed microemulsions have great potential for topical drug delivery in the treatment of inflammation and fungal infection.

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Topical gels of lidocaine HCl using cashew gum and Carbopol 940: Preparation and in vitro skin permeation

Cited by 105 publications

References 23 publications

Use of Cashew Bark Exudate Gum in the Preparation of 4 % Lidocaine HCL Topical Gels

Use of Cashew Bark Exudate Gum in the Preparation of 4 % Lidocaine HCL Topical Gels

Buccal patches of atenolol formulated using fenugreek (Trigonella foenum-graecum L.) seed mucilage

Design Development and Evaluation of Topical Microemulsion

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