Topical glycopyrrolate reduces axillary hyperhidrosis

Baker, DM

doi:10.1111/jdv.13745

Cited by 19 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…11 Although it is emerging as a promising option for focal HH, experience is strictly limited to craniofacial and axillary locations. 15,[85][86][87][88][89] Palmar use is limited by low skin permeability, as sufficient penetration through the stratum corneum remains an unmet need. 78 Since electric current application via iontophoresis has been shown to facilitate the absorption of glycopyrrolate across the palmar skin, research exploiting penetration-enhancing strategies, e. g., incorporation of permeation enhancers, may provide the rationale for successful palmar use.…”

Section: Emerging Therapies Of Palmar Hyperhidrosismentioning

confidence: 99%

<p>Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions</p>

Gregoriou

Sidiropoulou

Kontochristopoulos

et al. 2019

CCID

View full text Add to dashboard Cite

Palmar hyperhidrosis is a potentially disabling condition for which management remains a therapeutic challenge. Given the significant impact on quality of life, various treatment options are available, ranging from topical agents and medical devices to systemic therapies and surgical interventions. Nonsurgical approaches, i.e. topical antiperspirants, botulinum toxin injections, iontophoresis, and systemic agents, are all supported by the current literature. Patients with mild-to-moderate disease can often benefit from topical therapies only. As disease severity progresses, systemic oral medication, such as anticholinergic drugs, usually becomes necessary. Last-line surgical approaches (sympathetic denervation) should be reserved for severe refractory cases. Recently, therapeutic strategies have been evolving with several new agents emerging as promising alternatives in clinical trials. In practice, however, each modality comes with its own benefits and risks. An individual therapeutic ladder is generally recommended, taking into account disease severity, benefit-to-risk profile, treatment cost, patient preference, and clinician expertise. This review will provide an update on current and emerging concepts of management for excessive hand sweating to help clinicians optimize therapeutic decision-making.

show abstract

Section: Emerging Therapies Of Palmar Hyperhidrosismentioning

confidence: 99%

<p>Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions</p>

Gregoriou

Sidiropoulou

Kontochristopoulos

et al. 2019

CCID

View full text Add to dashboard Cite

show abstract

“…10 Subjects receiving topical anticholinergics have also reported systemic side-effects, the most common of which included dry mouth, dry eyes, urinary hesitation or less frequently, retention and constipation. 16 However, these systemic AEs could be prevented by developing a spray formulation 17 or the use of storage containers for drugimpregnated cotton pads. 18 In our case, based on the previous Phase 1 study in healthy subjects, it was expected that systemic exposure for the 1.85% solution would be observed when UMEC was administered to subjects with hyperhidrosis.…”

Section: Discussionmentioning

confidence: 99%

A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis

Nasir

Bissonnette

Maari

et al. 2017

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…[ 175 ] Topical application was also tested for the treatment of axillary hyperhidrosis. Patients treated with a 2% glycopyrrolate spray experienced a significant improvement of symptoms, [ 176 ] similar to patients treated with injections of botulinum toxin type A, a commonly used off‐label treatment for axillary hyperhidrosis. [ 177 ] Cream formulations containing 1% [ 178 ] or 2% [ 179 ] GPB were applied to successfully treat patients.…”

Section: Modulators Of the Cholinergic Systemmentioning

confidence: 99%

Current and emerging treatments targeting the neuroendocrine system for disorders of the skin and its appendages

Soeberdt

Kilić

Abels

2020

Experimental Dermatology

View full text Add to dashboard Cite

The skin as a neuroendocrine organ and the role of neuroendocrine signalling in the development of disorders affecting the skin and its appendages has received increasing attention in the last years. Different neuroendocrine systems have been described in the barrier organ skin, including the thyroid system, the hypothalamicpituitary-adrenal axis, the opioid, the endocannabinoid, the cholinergic, the secosteroidogenic and the serotonergic systems. All of these systems have been implicated in the development of skin diseases, which often have an inflammatory origin. These discoveries have led to an increase in the development of new drugs targeting components of neuroendocrine signalling pathways. Additionally, attempts have been made to repurpose already approved drugs targeting neuroendocrine signalling pathways in other organs for the treatment of skin diseases. Recently published results from preclinical and clinical studies look promising and may offer improved therapies to patients suffering from skin diseases in the near future. In this review, from a pharmaceutical point of view, we focus on recent progress in synthetic drug development of compounds targeting neuroendocrine signalling in the skin and its appendages to treat skin diseases such as atopic dermatitis, psoriasis, acne, alopecia areata and hyperhidrosis.

show abstract

Topical glycopyrrolate reduces axillary hyperhidrosis

Abstract: Topical glycopyrrolate spray could provide a further treatment modality to manage axillary hyperhidrosis.

Cited by 19 publications

References 24 publications

<p>Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions</p>

<p>Management Strategies Of Palmar Hyperhidrosis: Challenges And Solutions</p>

A phase 2a randomized controlled study to evaluate the pharmacokinetic, safety, tolerability and clinical effect of topically applied Umeclidinium in subjects with primary axillary hyperhidrosis

Current and emerging treatments targeting the neuroendocrine system for disorders of the skin and its appendages

Contact Info

Product

Resources

About