Topical Halometasone Reduces Acute Adverse Effects Induced by Pulsed Dye Laser for Treatment of Port Wine Stain Birthmarks

Gao, Lin; Qian, Linhan; Wang, Li; Li, Kai; Yin, Rong; Wang, Yanting; Kang, Hanmei; Song, Wenting; Wang, Gang

doi:10.15171/jlms.2018.05

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…In addition, photoprotection with sun avoidance and broad‐spectrum SPF 50 sunscreen is recommended to reduce the effects of epidermal damage. The use of topical steroids may be considered to reduce acute adverse effects from treatment 28 …”

Section: Laser and Light‐based Modalitiesmentioning

confidence: 99%

Light‐based treatment of pediatric port‐wine birthmarks

Tran

Kelly

Drolet

et al. 2020

Pediatric Dermatology

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Port-wine birthmarks (PWBs), often referred to as port-wine stains or capillary malformations, are progressive malformations composed of capillaries and post-capillary venules. They occur in up to 0.3% of newborns, present at birth as a pink to red patch, and often involve cosmetically sensitive areas including the face. 1 Over time, many PWBs darken in color, acquire secondary changes, including nodules and pyogenic granulomas, and develop soft-tissue hypertrophy that may involve underlying structures. 2,3 PWBs are now known to be caused by somatic mosaic mutations in genes that control cell-cycle regulation, including GNAQ, GNA11, PiK3CA, and others that are also implicated in cell-cycle signaling. 4 This finding has transformed our fundamental understanding of their pathophysiology, as these genes share oncogenic pathways that result in synchronous, tightly regulated cellular proliferation and growth. PWB can be isolated, or syndrome-associated, including Sturge-Weber syndrome (SWS), phakomatosis pigmentovascularis (PPV), or PiK3CA-related overgrowth syndromes (PROS). Genotypephenotype correlations exist for the most common mutations in vascular stains (GNAQ, GNA11, and PiK3CA hot spot, Figure 1). 4 While detailed mechanisms are not yet characterized, causative gain-offunction somatic mosaic mutations may explain the progressive development of nodularity, soft-tissue hypertrophy, and secondary vascular change of PWBs. [4][5][6] Given the progressive disfigurement associated with PWBs, parents often seek early treatment with laser and other light-based modalities. Early treatment of PWBs reduces the likelihood and severity of disfigurement and psychosocial morbidity. 3,7 In particular, the development of vascular-selective lasers led to a therapeutic shift in the management of PWBs and remains the first-line standard of treatment. In this article, we review principles of light-based treatment for pediatric port-wine birthmarks. | Selective photothermolysisThe use of lasers to treat vascular lesions relies on the theory of selective photothermolysis (SP); chromophores or light-absorbing targets can be targeted, heated, and damaged with minimal injury to the surrounding structures (Figure 2A). 8 For PWBs, the light-absorbing targets are oxyhemoglobin (absorption peaks at 418, 542, and 577 nm), deoxyhemoglobin (absorption peak between 750 and 800 nm), or methemoglobin (absorption at 620 nm, Figure 2B). 9 Three elements are necessary to achieve desired clinical effects in PWB lesions. First, the wavelength chosen must be preferentially

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Section: Laser and Light‐based Modalitiesmentioning

confidence: 99%

Light‐based treatment of pediatric port‐wine birthmarks

Tran

Kelly

Drolet

et al. 2020

Pediatric Dermatology

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Section: Resultsmentioning

confidence: 99%

“…It is very important to relieve these side effects, especially in the young population. Topical corticosteroids have been used to decrease the inflammatory response and prevent scarring (Bernstein, Schomacker, Paranjape, & Jones, ; Gao et al, ). Nd YAG lasers are also an important treatment option as they can affect the deep vascular structures of PWSs (Wang et al, ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of 577‐nm Pro‐Yellow laser in port wine stain treatment

Saraç

Kapıcıoğlu

2019

Dermatologic Therapy

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A port‐wine stain (PWS) is a congenital capillary malformation that is seen in 0.3–0.5% of newborns. Although many types of lasers have been used to treat PWSs, few studies have investigated the efficacy of 577‐nm Pro‐Yellow lasers. The aim of this study was to establish the efficacy of Pro‐Yellow lasers in PWS treatment. In total, 26 patients, comprising 15 females (57.7%) and 11 males (42.3%) with a mean age of 24.7 ± 11.8 (range 1–50) years were included in the study. All were treated with a 577‐nm Pro‐Yellow laser at 4‐week intervals, 3–10 times. The sessions initially used scan mode and a fluence dose of 24 J/cm2 per session, on average. The mean dose was increased by 4 J/cm each session and the maximum dose administered was 44 J/cm2. A mean regression of 68.8 ± 13.9% in the size of the lesions over 5.23 ± 2.7 sessions was observed. There was no statistically significant difference between the female and male patients when they were compared in terms of the number of treatment sessions (p = .789) and treatment success (p = .39). These case series demonstrate that the Pro‐Yellow laser is a safe and well‐tolerated treatment for PWSs. However, deep‐seated lesions required more treatment sessions and it was observed that clinically the lesions did not completely disappear.

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Complication rates and safety of pulsed dye laser treatment for port-wine stain: a systematic review and meta-analysis

Shi,

Yang,

et al. 2023

Lasers Med Sci

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Topical Halometasone Reduces Acute Adverse Effects Induced by Pulsed Dye Laser for Treatment of Port Wine Stain Birthmarks

Cited by 4 publications

References 23 publications

Light‐based treatment of pediatric port‐wine birthmarks

Light‐based treatment of pediatric port‐wine birthmarks

Efficacy of 577‐nm Pro‐Yellow laser in port wine stain treatment

Complication rates and safety of pulsed dye laser treatment for port-wine stain: a systematic review and meta-analysis

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