Topical Heparin Enhances Patency in a Rat Model of Arterial Thrombosis

Braam, M. J. I.; Cooley, Brian C.; Gould, John

doi:10.1097/00000637-199502000-00006

Cited by 25 publications

(13 citation statements)

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“…Treating locally with an irrigating solution containing 100 U/ml of hep- arin was shown to prolong APTT in rats within 20 min after reperfusion was established. 18 In our study, where a similar local treatment was given, there was no prolongation of APTT 120 min after reperfusion. From the above, it can be suggested that there is a possibility of a short-lived hemorrhagic risk in a small animal such as the rat.…”

Section: Bleedingsupporting

confidence: 45%

“…These findings are in agreement with previous studies. 18,19,22 To get an antithrombotic effect similar to local heparin treatment, our study showed that a fairly high systemic dosis of heparin (200 U/kg) is needed. This is likely to cause hemostatic problems in a large percentage of patients needing microvascular surgery.…”

Section: Bleedingmentioning

confidence: 91%

“…However, there was no statistical significant difference in blood loss between the two groups, and the amount of bleeding did not cause any observable hemostatic problems. In a rat with a total blood volume of 14 ml, 18 17-ll bleeding accounts for 0.12% of the blood volume. This corresponds to less than 10-ml blood loss in an average human being.…”

Section: Bleedingmentioning

confidence: 99%

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Local heparin is superior to systemic heparin in preventing arterial thrombosis

2002

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Thrombosis poses a significant problem in microvascular surgery, despite antithrombotic therapy. The purpose of the present study was to investigate whether a topical application of unfractionated heparin is equally efficient as a systemic bolus in avoiding thrombosis. A rat femoral artery model was used. Three different doses of systemic heparin (50, 100, and 200 U/kg) and one dose of locally administered heparin (100 U/ml) were evaluated and compared to a control group receiving isotonic saline. A thrombogenic injury, simulating poor microsurgical technique, was applied to the artery. The thrombus area was visualized by transillumination, and recorded for 60 min on video, for subsequent measurement. In addition, the level of activated partial thromboplastin time (APTT) and of anti-activated clotting factor X (aXa) was determined. Local heparin significantly reduced thrombus size as compared to isotonic saline and systemic heparin (50 and 100 U/kg). High-dose systemic heparin (200 U/kg) was equally potent, but local heparin had significantly less influence on the hemostatic parameters.

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Section: Bleedingsupporting

confidence: 45%

Section: Bleedingmentioning

confidence: 91%

Section: Bleedingmentioning

confidence: 99%

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Local heparin is superior to systemic heparin in preventing arterial thrombosis

2002

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“…Systemic infusions of heparin in some experimental models produce no improvement in skin flap survival over control solutions. 35 In practice, the authors use heparin topically as an irrigating solution at the site of microvascular thrombosis. Termed "low molecular weight heparin" (LMW heparin), this substance maintains inhibition of activated clotting factor X (factor Xa), while causing less elongation of clotting times (ptt).…”

Section: Pharmacotherapeutics: An Effort To Improve Free Flap Survivalmentioning

confidence: 99%

Ischemia/reperfusion injury in microvascular surgery

2000

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“…Expérimentalement, les résultats sont contradictoires, certains observent une diminution [16] du taux de thrombose postopératoire en ajoutant de l'héparine au sérum tandis que d'autres n'en retrouvent pas [17] (niveau III expérimental). Dans l'étude clinique prospective multicentrique de Khouri et al [3] (niveau III), l'adjonction d'héparine n'avait pas d'effet significatif sur le résultat des lambeaux.…”

Section: Auteursunclassified