Topical immunology of nasal allergy and mucosal IgE antibodies

Abstract

In the present study, the in vitro tissue-radioallergosorbent test (t-RAST) was performed in two groups of patients: one with perennial attacks of sneezing, serous hypersecretion and nasal congestion, the other with nasal congestion only. The results obtained were compared with those obtained by a series of conventional allergy tests. We then found that t-RAST provided objective data comparable to those obtained with serum-RAST and that the t-RAST is a reliable means of quantitatively detecting specific IgE antibodies in the nasal mucosa. t-RAST is of special value to diagnosticians because it is able to discern unequivocally and easily those patients with localized nasal allergy.

Nasal Allergy and Nasal Polyp with Special Reference to the Mucosal IgE Antibodies

“…This value was much smaller compared with that of inferior turbinate mucosa (104.6 ± 46.9 PRU/g) demonstrated by our previous study [Ohashi et al, 1985], It is tempting to suggest that IgE antibody located in nasal polyps may have been consequent on transfer of IgE antibody produced elsewhere and that the mucosa of nasal polyps may not actively synthesize IgE antibodies.…”

“…Thus, much remains to be established as to the interrelation between nasal allergies and nasal polyps. The present study was aimed at ascertaining by the t-RAST [Ohashi et al, 1983[Ohashi et al, , 1984[Ohashi et al, , 1985 whether and, if at all, to what extent IgE antibody might be de tected in the mucosa of nasal polyps of pa tients with nasal allergies and in those with out nasal allergies.…”

“…C; house dust, HD), provocation tests on infe rior turbinate mucosa (C, HD), nasal smear tests and serum RAST (s-RAST). and by the t-RAST of Ohashi et al [1985] on surgically obtained samples of nasal polyp mucosa. The level of HD-specific IgE antibodies thus detected in the nasal polyp mucosa was expressed as PRU/g.…”

“…The present study was designed to exam ine the relationship of nasal polyps and nasal allergies by the tissue-radioallergosorbent test (t-RAST) [Ohashi et al, 1983[Ohashi et al, , 1984[Ohashi et al, , 1985 on mucosal specimens of nasal polyps to measure the IgE antibody level in the tis sue. Electron microscopy of mast cells in nasal polyps was also conducted after a prov ocation with antigen applied onto the nasal polyp mucosa.…”

Nasal Allergen Sensitivity and Mucosal IgE Antibodies

“…As previously reported, the t-RAST shows an excellent specificity in diagnosing nasal allergies unequivocally and easily [Ohashi et al 1985b].…”