Topical interferon alpha 2 beta therapy in the management of conjunctival papilloma

Interferon α for the treatment of melanocytic conjunctival lesions

“…Interferon α-2b already showed good results in CIN and conjunctival papilloma [4][5][6][7], but there is still no overall answer to the application mode such as adjuvant therapy, solely therapy, intralesional application or combination therapy with other agents such as mitomycin C [8,10,13].…”

“…As a topical therapy with only very little side-effects for the patient, the subtype of topical interferon α-2b already showed effectiveness in conjunctival intraepithelial neoplasia (CIN) and conjunctival papilloma [4][5][6][7]. In previous case studies, topical interferon α-2b has been applied solely [6], adjuvant after excisional biopsy [4], in cycles combined or after being treated with mitomycin C already [8,13] or intralesionally [9].…”

Conjunctival papilloma: Clinical features, outcome, and factors related to recurrence

“…Various adjunctive therapeutic modalities such as double freeze-thaw cryotherapy, CO 2 laser, oral cimetidine, and topical MMC or interferon α-2b have been suggested to reduce the recurrence rate of conjunctiva papilloma. [ 2 3 4 5 6 7 8 9 10 11 ] In our series, the most common treatment modality was surgical excision with adjunctive cryotherapy, and/or topical MMC, and/or CO 2 laser, which got a relatively lower recurrence rate (7%) in these patients as compared to those without adjunctive treatment (50%). The double freeze-thaw cryotherapy is a preferred method of adjunctive therapy for squamous cell papillomas with less scarring formation and a relatively lower recurrence rate.…”

“…Other interventions including perilesional cryotherapy, intralesional or topical interferon-α injection, carbon dioxide (CO 2 ) laser, topical mitomycin-C (MMC), and oral cimetidine have been reported to be as adjunctive treatments. [ 2 3 4 5 6 7 8 ] Despite the multiple choices of treatment modalities for treating conjunctival papilloma, recurrences are not uncommon. In this study, we investigate the clinical features, treatment, and postoperative outcome of conjunctival papilloma, to identify the related significant factors for recurrence.…”

Resolution of recurrent conjunctival papilloma after topical and intralesional interferon α2b with partial excision in a child

“…9 Topical IFN a2b was used as an adjunct to the surgical excision / systemic IFN a2b in the reports from 1990 through 2009. 5 However, Schechter and colleagues 4 and Falco and colleagues in 2007, 10 reported complete resolution of conjunctival papilloma with topical IFN a2b alone. The resolution occurred within 3 months in the first case and within 2 weeks in the second.…”