2016
DOI: 10.1007/s00520-016-3521-7
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Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review

Abstract: There was no strong evidence that indicates differences between topical pharmacological interventions or non-pharmacological topical controls in the prevention of acute radiation dermatitis among patients with head and neck cancer undergoing radiotherapy.

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Cited by 70 publications
(57 citation statements)
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“…The list included: aloe vera, Aquaphor, udder cream, Radiaplex ® , corticosteroid creams, lidocaine cream, Silvadine ® , and antibiotic ointment. Topical agents are distributed to patients without supportive evidence of therapeutic benefit [5, 11, 30]. Many studies have evaluated the use of topical corticosteroids with mixed results [5, 39].…”
Section: Discussionmentioning
confidence: 99%
“…The list included: aloe vera, Aquaphor, udder cream, Radiaplex ® , corticosteroid creams, lidocaine cream, Silvadine ® , and antibiotic ointment. Topical agents are distributed to patients without supportive evidence of therapeutic benefit [5, 11, 30]. Many studies have evaluated the use of topical corticosteroids with mixed results [5, 39].…”
Section: Discussionmentioning
confidence: 99%
“…The severity of the RD is influenced by the treatment modality (RT or CRT), total dose and its fraction, site and volume of the tissue involved, and treatment time. Individual patient related factors such age, comorbidities, and genetic predisposition also influence the extent of skin reaction 105 …”
Section: Introductionmentioning
confidence: 99%
“…Up to 90% of the HNC patients experience skin reactions and 25% of these patients show Grade 3 RD. Higher grades of RD are usually seen in the patients who undertake CRT and they may present with thinning of the skin and even necrosis 105,106 . Such severe reactions may interrupt the treatment schedule and alter the delivery of the optimum dosage, and thus have a negative influence on the tumor prognosis 107 .…”
Section: Introductionmentioning
confidence: 99%
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“…5 Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients are still not effective and not routinely used. 6 This report follows the recommendations from the CARE Statement for writing case reports. …”
Section: Introductionmentioning
confidence: 99%