Topical Isotretinoin and Photodamage

Cunningham, W. J.; Bryce, Graeme F.; Armstrong, R. B.; Lesiewicz, Jeanne; Kim, H. J.; Sendagorta, E.

doi:10.1159/000420338

Cited by 3 publications

(2 citation statements)

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“…Cunningham evaluated the potential of topical 0.1% isotretinoin cream in a randomized study of 6 months. Isotretinoin-treated patients showed statistically significant improvement in the various symptoms of photoaging like fine wrinkles and pigmentation as compared with placebo-treated subjects (Cunningham 1990). Later, in 2 separate studies, the potential of isotretinoin in treating patients suffering from mild to moderate photodamage was evaluated by Sendagorta and colleagues (1992) (n = 776) and Armstrong and colleagues (1992) (n = 326) in double-blind, vehicle-controlled clinical trials.…”

Section: Tretinoinmentioning

confidence: 99%

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Mukherjee¹,

Date²,

Patravale³

et al. 2006

Clinical Interventions in Aging

423

318

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Aging of skin is an intricate biological process consisting of two types. While intrinsic or chronological aging is an inevitable process, photoaging involves the premature aging of skin occurring due to cumulative exposure to ultraviolet radiation. Chronological and photoaging both have clinically differentiable manifestations. Various natural and synthetic retinoids have been explored for the treatment of aging and many of them have shown histological and clinical improvement, but most of the studies have been carried out in patients presenting with photoaged skin. Amongst the retinoids, tretinoin possibly is the most potent and certainly the most widely investigated retinoid for photoaging therapy. Although retinoids show promise in the treatment of skin aging, irritant reactions such as burning, scaling or dermatitis associated with retinoid therapy limit their acceptance by patients. This problem is more prominent with tretinoin and tazarotene whereas other retinoids mainly represented by retinaldehyde and retinol are considerably less irritating. In order to minimize these side effects, various novel drug delivery systems have been developed. In particular, nanoparticles have shown a good potential in improving the stability, tolerability and efficacy of retinoids like tretinoin and retinol. However, more elaborate clinical studies are required to confirm their advantage in the delivery of topical retinoids.

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Section: Tretinoinmentioning

confidence: 99%

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Mukherjee¹,

Date²,

Patravale³

et al. 2006

Clinical Interventions in Aging

423

318

View full text Add to dashboard Cite

show abstract

“…After the first report on clinical improvement of photoaged skin with isotretinoin, 59 two vehicle‐controlled studies revealed the beneficial effects of topical isotretinoin 60,61 . In both studies, after the initial application of a 0·05% formulation, the concentration of isotretinoin was increased to 0·1% in the second part of the study 60,61 .…”

Section: Clinical Efficacy and Safety Of Topical Retinoids In The Manmentioning

confidence: 99%

Topical retinoids in the management of photodamaged skin: from theory to evidence-based practical approach

Darlenski

Surber²,

Fluhr³

2010

British Journal of Dermatology

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Skin, being exposed directly to the environment, represents a unique model for demonstrating the synergistic effects of intrinsic and extrinsic factors on the ageing process. Ultraviolet radiation (UVR) is the major factor among exogenous stressors responsible for premature skin ageing. The problem of skin ageing has captured public attention and has an important social impact. Different therapeutic approaches have been developed to treat cutaneous ageing and to diminish or prevent the negative effects of UVR. Topical retinoids represent an important and powerful class of molecules in the dermatologist's hands for the treatment of photodamaged skin. Since their introduction more than 20 years ago, topical retinoids have shown beneficial efficacy and good safety profiles in the management of photodamaged skin, and as therapeutic anti-ageing agents. This review provides a brief retrospective of the development of topical retinoids in the treatment of photodamaged skin, elucidates their mechanism of action, delineates their use and addresses clinical, pharmaceutical and regulatory issues in connection with their intended use.

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Photoaging

Cunningham¹

2002

Journal of Toxicology: Cutaneous and Ocular Toxicology

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Topical Isotretinoin and Photodamage

Cited by 3 publications

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Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety

Topical retinoids in the management of photodamaged skin: from theory to evidence-based practical approach

Photoaging

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