Topical isotretinoin in Darier's disease

Burge, Susan; Buxton, P K

doi:10.1111/j.1365-2133.1995.tb06927.x

Cited by 49 publications

(19 citation statements)

References 14 publications

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“…26 Topical therapies, such as steroids or vitamin D3 ointment, are widely used for the treatment of DD. 22 In addition, isotretinoin, 27 tazarotene 28 and adapalene (naphthoic acid) 29 have been evaluated as treatments for DD symptoms. For refractory proliferative lesions, surgical dissection using an yttrium-aluminum-garnet laser is sometimes performed.…”

Section: Treatmentmentioning

confidence: 99%

Darier disease

Takagi

and

Ikeda

2016

The Journal of Dermatology

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Darier disease (DD) is a type of inherited keratinizing disorder that exhibits autosomal dominant inheritance. DD is caused by the mutations of ATP2A2, which encodes an endoplasmic reticulum calcium pump, sarco/endoplasmic reticulum ATPase type 2 (SERCA2). DD often develops in childhood, persists through adolescence, and causes small papules predominantly in seborrheic areas such as the face, chest and back. Further, scales and scabs may gradually develop. DD may be accompanied by non-dermal symptoms, including psychiatric symptoms. Histologically, DD is characterized by corps ronds and grains in addition to suprabasal cleavage. There are no currently validated curative treatments available for DD, with the majority of cases treated symptomatically. Despite demonstrating efficacy in the treatment of DD, the use of oral retinoids has been limited due to the association with various adverse effects.

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Section: Treatmentmentioning

confidence: 99%

Darier disease

Takagi

and

Ikeda

2016

The Journal of Dermatology

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“…Use of accutane/isotretinoin, a 13-cis retinoic acid formulation, commonly prescribed for the treatment of nodular acne, has proven to provide temporary symptomatic relief in DD [1,10,60]. Withdrawal from an accutane regimen has been reported to cause the return of DD symptoms [10,60]. Although, it is not known how accutane functions in DD, our results indicate that in DD keratinocytes, isotretinoin suppresses cell proliferation and perhaps promotes apoptotic cell death as a result of a reduction in TRPC1-mediated Ca 2+ influx [44].…”

Section: Mitigation Perspectivementioning

confidence: 99%

“…Use of oral and topical retinoid therapy seems to be promising at present, albeit with a modest rate of success. Use of accutane/isotretinoin, a 13-cis retinoic acid formulation, commonly prescribed for the treatment of nodular acne, has proven to provide temporary symptomatic relief in DD [1,10,60]. Withdrawal from an accutane regimen has been reported to cause the return of DD symptoms [10,60].…”

Section: Mitigation Perspectivementioning

confidence: 99%

Darier’s disease: a calcium-signaling perspective

Pani

Singh

2007

Cell. Mol. Life Sci.

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Ca 2+ influx evoked across the plasma membrane upon internal store depletion is essential for a myriad of cellular functions including gene expression, cell proliferation, differentiation and even apoptosis. Darier's disease (DD), an autosomal dominant inherited disorder of the skin, arising due to mutations in the isoform 2 of the sarco (endo) plasmic reticulum Ca 2+ ATPase (SERCA2), exemplifies an anomaly of Ca 2+ signaling disturbances. Owing to loss of function mutations in SERCA2, keratinocytes in DD patients have a reduced pool of endoplasmic reticulum (ER) Ca 2+ . Importantly, the status of ER Ca 2+ is critical for the activation of a class of plasma membrane Ca 2+ channels referred to as store operated Ca 2+ channels (SOCs). The widely expressed transient receptor potential (TRP) family of channels is proposed to be SOCs. In this review we discuss DD from the viewpoint of Ca 2+ signaling and present a potential role for TRPC1 in the disease pathogenesis.

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“…Als Therapiemöglichkeiten stehen Anwendungen mit topischen Steroiden [7], Vitamin-A-Säure (0,2-1%; [8]), aktiviertem Vitamin D 3 [28], Tacrolimus [27], 5-Fluorouracil [21,32] oder oralen sowie topischen Retinoiden [13,24] zur Verfü-gung. Ferner wurde bereits über Therapieversuche mittels photodynamischer Therapie [31], Dermabrasion [12], Kryotherapie [14], verschiedener Lasersysteme [4,22] und elektrokaustische Therapien [30] [19].…”

Section: Diskussionunclassified

Segmentaler Morbus Darier

et al. 2009

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Darier disease is often associated with pruritus and an unpleasant odor, causing medical and emotional problems. Ablative laser therapy has proven effective in ameliorating these symptoms. Side effects of this approach include permanent hypopigmentation and a risk of scarring. We present two cases where non-ablative therapy with pulsed dye lasers proved a safe and effective way to manage the intertriginous lesions. Although the mechanism of action is unclear, our success indicates that pulsed dye laser therapy is an option in Darier disease. Larger numbers of patients, ideally in multicenter studies, must be treated in this way to confirm our results.

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Topical isotretinoin in Darier's disease

Cited by 49 publications

References 14 publications

Darier disease

Darier disease

Darier’s disease: a calcium-signaling perspective

Segmentaler Morbus Darier

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