Topical Ivermectin for Permethrin-Resistant Scabies: A Useful Application

Gnesotto, Laura; Cutrone, Mario; Mazzatenta, Carlo; Bassi, Andrea; Piccolo, Vincenzo; Sechi, Andrea

doi:10.5826/dpc.1401a29

Dermatol Pract Concept

2024

DOI: 10.5826/dpc.1401a29

|View full text |Cite

Topical Ivermectin for Permethrin-Resistant Scabies: A Useful Application

Laura Gnesotto,

Mario Cutrone,

Carlo Mazzatenta

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Escalating Threat of Drug-Resistant Human Scabies: Current Insights and Future Directions

Simonart,

Lam Hoai

2024

JCM

View full text Add to dashboard Cite

Background: Scabies is a prevalent dermatological condition with significant public health implications. The recent rise in drug-resistant scabies presents new challenges for effective disease management and control. Methods: A comprehensive literature review was conducted using PubMed, Cochrane Library, and Web of Science. Studies published from 2000 to August 2024 were considered, focusing on those reporting drug-resistant scabies and advancements in treatment approaches. Results: Clinical studies, in vitro investigations, and case reports show significant resistance of human scabies to permethrin. Main resistance mechanisms involve genetic mutations in the mites’ voltage-gated sodium channels (VGSCs) and enhanced activity or expression of the detoxifying enzyme glutathione S-transferase (GST). Resistance to ivermectin and benzyle benzoate, although suggested by some authors, seems less obvious. The clinical evidence of widespread ivermectin resistance in human scabies infestations is lacking, despite indications of increased tolerance in laboratory settings and anecdotal reports of resistance in patients with crusted scabies. Benzyl benzoate resistance in scabies mites remains unconfirmed. Conclusions: Permethrin-resistant scabies is an escalating threat requiring new management strategies and updated guidelines. Infection control measures, alternative treatments, and ongoing research into new therapeutics are crucial to mitigate the impact of drug-resistant scabies.

show abstract

Escalating Threat of Drug-Resistant Human Scabies: Current Insights and Future Directions

Simonart,

Lam Hoai

2024

JCM

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Topical Ivermectin for Permethrin-Resistant Scabies: A Useful Application

Cited by 1 publication

References 2 publications

Escalating Threat of Drug-Resistant Human Scabies: Current Insights and Future Directions

Escalating Threat of Drug-Resistant Human Scabies: Current Insights and Future Directions

Contact Info

Product

Resources

About