Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review

Fields, Jaime R.; Vonu, Peter; Monir, Reesa L; Schoch, Jennifer J.

doi:10.1111/dth.13202

Cited by 21 publications

(16 citation statements)

References 37 publications

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“…The process of miniaturization is androgen‐mediated in males. In women, female pattern hair loss (FPHL) has emerged as the preferred term for androgenetic alopecia due to the uncertain relationship between androgens and this entity 4‐6 . However, literature supports the effectiveness of finasteride and dutasteride therapy in women with FPHL 7,8 .…”

Section: Introductionmentioning

confidence: 99%

5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety

Dhurat

Sharma

Rudnicka

et al. 2020

Dermatologic Therapy

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Androgenetic alopecia (AGA) is a multifactorial disease that carries a significant psychological burden with it. Dihydrotestosterone, the main pathogenic androgen in AGA, is produced by conversion of testosterone, which is catalyzed by the 5‐alpha reductase (5‐AR) isoenzyme family. Finasteride and dutasteride are inhibitors of these enzymes. Finasteride, which is a single receptor 5‐alpha reductase inhibitor (5‐ARI), acts by blocking dihydrotestosterone (DHT). Dutasteride, a dual receptor DHT blocker, has a higher potency than its predecessor, finasteride. This review corroborates the evidence of superiority of dutasteride over finasteride, and its comparable safety profile concerning fertility, teratogenicity, neurotoxicity, and hepatotoxicity.

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Section: Introductionmentioning

confidence: 99%

5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety

Dhurat

Sharma

Rudnicka

et al. 2020

Dermatologic Therapy

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“…This systematic review suggests a randomized controlled trial to evaluate this drug. 26 Moreover, the treatment modality is co-adjuvant therapy. The first choice is hair transplantation.…”

Section: Discussionmentioning

confidence: 99%

Update Treatment of Male Androgenetic Alopecia

Trilisnawati

Diba

Kurniawati

et al. 2021

BIKK

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Background: Male androgenetic alopecia (MAGA), also known as androgenetic alopecia, is the most common hair loss in males who have a genetic predisposition. The pattern of baldness in MAGA starts from the frontal area in a triangular pattern, followed by progressive thinning of the vertex until baldness occurs. Generally, the diagnosis of MAGA is established by clinical examination. FDA has approved a combination of topical minoxidil and oral finasteride for MAGA treatment. Currently, there is another treatment option like dutasteride, a prostaglandin analog, ketoconazole, and co-adjuvant therapy like laser therapy, hair transplantation, and so on. Purpose: To provide an updated treatment for MAGA. Review: Etiopathogenesis of MAGA is influenced by genetic susceptibility and hormonal factors. The European Consensus Group set the evaluation diagnosis of MAGA to include a historyof hair fall, physical examination, hair examination, supporting examination, and clinical documentation. There are therapeutic options for MAGA, including antiandrogen therapies, androgen-independent therapies, and co-adjuvant therapies. The FDA has approved a combination of topical minoxidil and oral finasteride for MAGA treatment. MAGA may affect patients’ quality of life and self-esteem. In general, patients expect higher. Conclusion: MAGA is the most common progressive hair loss in males. The MAGA therapy is expected to achieve cosmetically significant regrowth and to slow additional hair loss.

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“…A systematic review of ketoconazole for the treatment of AGA revealed increased hair shaft diameter and increase in pilary index (percent anagen phase ×diameter) following treatment. Studies also demonstrated clinical improvement of AGA based on photographic evaluation 149 . Shampoos containing 2% ketoconazole may be applied to the scalp as a promising adjuvant or alternative therapy in the treatment of AGA.…”

Section: Supplements and Otc Treatmentsmentioning

confidence: 96%

Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics

Nestor

Ablon

Gade

et al. 2021

J of Cosmetic Dermatology

181

105

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Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review

Cited by 21 publications

References 37 publications

5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety

5‐Alpha reductase inhibitors in androgenetic alopecia: Shifting paradigms, current concepts, comparative efficacy, and safety

Update Treatment of Male Androgenetic Alopecia

Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics

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