Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries

Esparza, Francisco A.; Cobian, C.; Jiménez, J.F. Masa; Garcia-Cota, J. J.; Sanchez, C Puente; Maestro, Annamaria Del; Santiago, Darby E.; Cusi, Mel

doi:10.1136/bjsm.2006.030239

Cited by 21 publications

(13 citation statements)

References 12 publications

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“…Various topical therapies have been employed in an attempt minimize pain and enhance muscle strength after soft-tissue injury. [1][2][3] These therapies including the application of ice and menthol gels have been employed by athletic trainers, physical therapists, and other health care providers in an attempt to minimize the injury and return the individual to training or competition as soon as possible. 4 The cooling effect of menthol has also been postulated to affect blood fl ow, although there are limited data to support this claim.…”

mentioning

confidence: 99%

Comparison of the Effects of Ice and 3.5% Menthol Gel on Blood Flow and Muscle Strength of the Lower Arm

Topp¹,

Winchester²,

Mink³

et al. 2011

Journal of Sport Rehabilitation

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Context:Soft-tissue injuries are commonly treated with ice or menthol gels. Few studies have compared the effects of these treatments on blood flow and muscle strength.Objective:To compare blood flow and muscle strength in the forearm after an application of ice or menthol gel or no treatment.Design:Repeated-measures design in which blood-flow and muscle-strength data were collected from subjects under 3 treatment conditions.Setting:Exercise physiology laboratory.Participants:17 healthy adults with no impediment to the blood flow or strength in their right arm, recruited through word of mouth.Intervention:Three separate treatment conditions were randomly applied topically to the right forearm: no treatment, 0.5 kg of ice, or 3.5 mL of 3.5% menthol gel. To avoid injury ice was only applied for 20 min.Main Outcome Measures:At each data-collection session blood flow (mL/min) of the right radial artery was determined at baseline before any treatment and then at 5, 10, 15, and 20 min after treatment using Doppler ultrasound. Muscle strength was assessed as maximum isokinetic flexion and extension of the wrist at 30°/s 20, 25, and 30 min after treatment.Results:The menthol gel reduced (−42%, P < .05) blood flow in the radial artery 5 min after application but not at 10, 15, or 20 min after application. Ice reduced (−48%, P < .05) blood flow in the radial artery only after 20 min of application. After 15 min of the control condition blood flow increased (83%, P < .05) from baseline measures. After the removal of ice, wrist-extension strength did not increase per repeated strength assessment as it did during the control condition (9−11%, P < .05) and menthol-gel intervention (8%, P < .05).Conclusions:Menthol has a fast-acting, short-lived effect of reducing blood flow. Ice reduces blood flow after a prolonged duration. Muscle strength appears to be inhibited after ice application.

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mentioning

confidence: 99%

Comparison of the Effects of Ice and 3.5% Menthol Gel on Blood Flow and Muscle Strength of the Lower Arm

Topp¹,

Winchester²,

Mink³

et al. 2011

Journal of Sport Rehabilitation

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“…Detailed information can be found in the Supplemental Table (available online at http:// www.mayoclinicproceedings.org). The most commonly studied agents were NSAIDs (n¼26), [30][31][32]37,39,51,52,54,58,61,64,71,72,74,78,[80][81][82][84][85][86][87][88][89][90][91] followed by lidocaine (n¼9), 33,36,[40][41][42][43]55,65,83 capsaicin (n¼6), 29,35,38,53,73,75 and amitriptyline (n¼5). 45,47,59,67,68 Other agents studied included glyceryl trinitrate (n¼3), 44,48,69 opioids (n¼2), 50,60 menthol (n¼2), ...…”

Section: Study Characteristicsmentioning

confidence: 99%

Topical Analgesics in the Management of Acute and Chronic Pain

Argoff

2013

Mayo Clinic Proceedings

109

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Oral analgesics are commonly prescribed for the treatment of acute and chronic pain, but these agents often produce adverse systemic effects, which sometimes are severe. Topical analgesics offer the potential to provide the same analgesic relief provided by oral analgesics but with minimal adverse systemic effects. This article describes the results of a systematic review of the efficacy of topical analgesics in the management of acute and chronic pain conditions. A literature search of MEDLINE/PubMed was conducted using the keywords topical analgesic AND chronic pain OR acute pain OR neuropathic pain and focused only on individual clinical trials published in English-language journals. The search identified 92 articles, of which 65 were eligible for inclusion in the review. The most commonly studied topical analgesics were nonsteroidal anti-inflammatory drugs (n=27), followed by lidocaine (n=9), capsaicin (n=6), amitriptyline (n=5), glyceryl trinitrate (n=3), opioids (n=2), menthol (n=2), pimecrolimus (n=2), and phenytoin (n=2). The most common indications were acute soft tissue injuries (n=18), followed by neuropathic pain (n=17), experimental pain (n=6), osteoarthritis and other chronic joint-related conditions (n=5), skin or leg ulcers (n=5), and chronic knee pain (n=2). Strong evidence was identified for the use of topical diclofenac and topical ibuprofen in the treatment of acute soft tissue injuries or chronic joint-related conditions, such as osteoarthritis. Evidence also supports the use of topical lidocaine in the treatment of postherpetic neuralgia and diabetic neuropathy. Currently, limited evidence is available to support the use of other topical analgesics in acute and chronic pain.

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“…A recent systematic review of randomised controlled trials concluded that topical NSAIDs are effective in relieving the pain associated with soft tissue injuries without causing serious adverse effects. [15][16][17][18][19] However, NSAID patches are not effective in prophylactic use to prevent delayed onset muscle soreness (DOMS) in trained athletes. 20 …”

Section: Topical Nsaidsmentioning

confidence: 99%

Pain management in sports medicine: Use and abuse of anti-inflammatory and other agents

Derman

Schwellnus

2010

South African Family Practice

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Topical ketoprofen TDS patch versus diclofenac gel: efficacy and tolerability in benign sport related soft-tissue injuries

Cited by 21 publications

References 12 publications

Comparison of the Effects of Ice and 3.5% Menthol Gel on Blood Flow and Muscle Strength of the Lower Arm

Comparison of the Effects of Ice and 3.5% Menthol Gel on Blood Flow and Muscle Strength of the Lower Arm

Topical Analgesics in the Management of Acute and Chronic Pain

Pain management in sports medicine: Use and abuse of anti-inflammatory and other agents

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