Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery

Solomon, Kerry D.; Cheetham, Janet K; DeGryse, Ronald; Brint, Stephen F.; Rosenthal, Allan

doi:10.1016/s0161-6420(00)00543-1

Cited by 73 publications

(48 citation statements)

References 12 publications

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“…In the earlier studies which were done, the topical NSAIDs like flurbiprofen ketorolac, bromofenac and diclofenac had been evaluated for their anti-inflammatory actions and the prevention of intraoperative miosis and cystoids macular oedema [15][16][17][18].…”

Section: Group I Flurbiprofenmentioning

confidence: 99%

A Prospective, Open-label Study to Compare the Efficacy and the Safety of Topical Loteprednol Etabonate and Topical Flurbiprofen Sodium in Patients with Post-Operative Inflammation after Cataract Extraction

Bannale

Pundarikaksha²,

Sowbhagya³

2012

JCDR

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Purpose: To study the effect of the topical Non-Steroidal Anti Inflammatory Drug (NSAID), Flurbiprofen 0.03%, as an alternative to the topical steroids for the postoperative control of inflammation in cataract surgeries. Methods:The effect of the topical NSAID, flurbiprofen sodium 0.03%, was studied and compared with that of the topical steroid -Loteprednol etabonate 0.5% suspension (as eye drops) in a prospective, open labelled study. Both the groups (20 patients each) were similar in the baseline parameters. The postoperative inflammatory response following the standard, small incision, extra capsular cataract extraction was assessed in both the groups for 28 post-operative days. The parameters which were considered for the study were conjunctival hyperaemia, ciliary congestion, corneal oedema, cells in the anterior chamber, aqueous flare and ocular pain. The severity of the postoperative inflammatory responses for both the drugs was graded on the post-operative days 1, 7, 14, 21 and 28 and it was statistically analyzed. Results:The 2 groups did not differ statistically in the effect of the treatment for any of the variables, which included aqueous cells, flare, ciliary congestion and conjunctival congestion (p< 0.001). Both the drugs were well tolerated and no severe adverse Drug Reactions (ADRs) were caused by the topical NSAID and the topical steroid. Conclusion:The topical NSAID, Flurbiprofen, is as effective as the topical corticosteroid, Loteprednol and it can be used as an alternative in the routine postoperative treatment following uncomplicated cataract surgeries.

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Section: Group I Flurbiprofenmentioning

confidence: 99%

A Prospective, Open-label Study to Compare the Efficacy and the Safety of Topical Loteprednol Etabonate and Topical Flurbiprofen Sodium in Patients with Post-Operative Inflammation after Cataract Extraction

Bannale

Pundarikaksha²,

Sowbhagya³

2012

JCDR

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“…4 Required quantity of diclofenac sodium was dissolved in 100 ml of 0.0667M isotonic phosphate buŠer (pH 7.4) to have 0.05, 0.1 and 0.15％ (w/v) concentrations.…”

Section: Experimental Materialsmentioning

confidence: 99%

“…1) Non-steroidal anti-in‰ammatory drugs (NSAIDs) such as indomethacin, 2) ‰urbiprofen, 3) ketorolac 4) and diclofenac, 5) have been found to be viable alternative to corticosteroids in the management of ocular in‰ammation. Diclofenac and ketorolac were found neither to attenuate the antiviral activity of cefdovir nor to facilitate the adenoviral replication.…”

Section: Introductionmentioning

confidence: 99%

Effect of Formulation Factors on <i>In Vitro</i> Permeation of Diclofenac from Experimental and Marketed Aqueous Eye Drops through Excised Goat Cornea

Ahuja

Dhake²,

Majumdar

2006

YAKUGAKU ZASSHI

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The eŠect of formulation factors on permeation of diclofenac from some experimental and marketed aqueous eye drops through excised goat cornea was evaluated. Raising the pH of formulation from 6.0 to 8.0 or diclofenac concentration from 0.05 to 0.15％ (w/v) or adjusting tonicity with mannitol or addition of viscolizing agent decreased apparent permeability coe‹cient (Papp). Formulation (pH 7.4) containing sodium metabisulˆte or EDTA or combination of methyl and propyl paraben showed signiˆcantly (p＜0.05) higher Papp whereas benzalkonium chloride (BAC) had no eŠect and sorbic acid (SA) had reduced permeation. Surprisingly marketed drops containing BAC or SA, showed signiˆcantly ( p＜0.05) higher Papp and decreased in the order of Difen＞Voveran＞NSAID＞Dicol＞Diclolab. Lower pH (7.1-7.3) and surface tension of drops indicating presence of surfactant, could mediate increased permeation and presence of buŠer could cause irritation on in vivo instillation. The marketed formulations showed corneal hydration ＞ 83％ suggesting corneal damaging potential.

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“…1) Steroids also exacerbate ocular infections and diminish corneal/stromal wound healing. 2) Nonsteroidal antiin‰ammatory drugs (NSAIDs) like indomethacin, 3) ‰urbiprofen, 4) ketorolac, 5) and diclofenac 6) have been found to be viable alternatives to steroids in treating ocular in‰ammation. Diclofenac is reported to be more eŠective than prednisolone sodium phosphate in inhibiting the breakdown of the bloodaqueous barrier.…”

Section: Introductionmentioning

confidence: 99%

<i>In Vitro</i> Corneal Permeation of Diclofenac from Oil Drops

2007

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Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery

Cited by 73 publications

References 12 publications

A Prospective, Open-label Study to Compare the Efficacy and the Safety of Topical Loteprednol Etabonate and Topical Flurbiprofen Sodium in Patients with Post-Operative Inflammation after Cataract Extraction

A Prospective, Open-label Study to Compare the Efficacy and the Safety of Topical Loteprednol Etabonate and Topical Flurbiprofen Sodium in Patients with Post-Operative Inflammation after Cataract Extraction

Effect of Formulation Factors on <i>In Vitro</i> Permeation of Diclofenac from Experimental and Marketed Aqueous Eye Drops through Excised Goat Cornea

<i>In Vitro</i> Corneal Permeation of Diclofenac from Oil Drops

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