Topical Leptospermum Honey (Medihoney) in Recalcitrant Venous Leg Wounds

Smith, Tanisha; Legel, Kennedy; Hanft, Jason R.

doi:10.1097/01.asw.0000345283.05532.9a

Cited by 9 publications

(10 citation statements)

References 11 publications

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“…Several in vitro studies have confirmed the antibacterial effects of these products [ 99 , 100 ]. Furthermore, randomized controlled trials and case studies have demonstrated the antibacterial and wound healing effects of these products in the clinical setting [ 73 , 101 , 102 , 103 , 104 , 105 ]. Simon et al detailed the treatment of various surgical wounds and drainage sites in pediatric oncology patients with a Medihoney ® alginate wound covering, and reported that the honey reduced irritation and cleared infections.…”

Section: Commercializationmentioning

confidence: 99%

Honey-Based Templates in Wound Healing and Tissue Engineering

2018

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Over the past few decades, there has been a resurgence in the clinical use of honey as a topical wound treatment. A plethora of in vitro and in vivo evidence supports this resurgence, demonstrating that honey debrides wounds, kills bacteria, penetrates biofilm, lowers wound pH, reduces chronic inflammation, and promotes fibroblast infiltration, among other beneficial qualities. Given these results, it is clear that honey has a potential role in the field of tissue engineering and regeneration. Researchers have incorporated honey into tissue engineering templates, including electrospun meshes, cryogels, and hydrogels, with varying degrees of success. This review details the current state of the field, including challenges which have yet to be overcome, and makes recommendations for the direction of future research in order to develop effective tissue regeneration therapies.

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Section: Commercializationmentioning

confidence: 99%

Honey-Based Templates in Wound Healing and Tissue Engineering

2018

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“…Manuka honey has, however, been used to treat animals with surgical or accidental wounds, particularly horses, with positive outcomes ( Dart et al, 2015 ; Bischofberger et al, 2016 ). Case reports using honey for non-healing wounds and ulcers have noted significant improvement with resolution of infection where conventional antibiotics had failed ( Regulski, 2008 ; Smith et al, 2009 ). However, despite this and the evidence from numerous in vitro and in vivo models that honey kills problematic wound pathogens, there is a paucity of robust clinical data for manuka honey.…”

Section: Evidence Of Efficacy From Animal Studies Case Reports and mentioning

confidence: 99%

Therapeutic Manuka Honey: No Longer So Alternative

et al. 2016

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Medicinal honey research is undergoing a substantial renaissance. From a folklore remedy largely dismissed by mainstream medicine as “alternative”, we now see increased interest by scientists, clinical practitioners and the general public in the therapeutic uses of honey. There are a number of drivers of this interest: first, the rise in antibiotic resistance by many bacterial pathogens has prompted interest in developing and using novel antibacterials; second, an increasing number of reliable studies and case reports have demonstrated that certain honeys are very effective wound treatments; third, therapeutic honey commands a premium price, and the honey industry is actively promoting studies that will allow it to capitalize on this; and finally, the very complex and rather unpredictable nature of honey provides an attractive challenge for laboratory scientists. In this paper we review manuka honey research, from observational studies on its antimicrobial effects through to current experimental and mechanistic work that aims to take honey into mainstream medicine. We outline current gaps and remaining controversies in our knowledge of how honey acts, and suggest new studies that could make honey a no longer “alternative” alternative.

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“…179,180 However, the published data pointed out to a considerable enhancement of infection clearing after unsuccessful antibiotic treatment. 179,180 …”

Section: Control Of Human Pathogens With Honeymentioning

confidence: 99%

Honey as a Complementary Medicine

Miguel

Antunes

Faleiro

2017

Integr Med�Insights

137

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The beneficial effects of honey on human health have long been recognized. Today, many of those positive effects have been studied to elucidate its mode of action. This review briefly summarizes the best studied features of honey, highlighting it as an appealing alternative medicine. In these reports, the health benefits of honey range from antioxidant, immunomodulatory, and anti-inflammatory activity to anticancer action, metabolic and cardiovascular benefits, prebiotic properties, human pathogen control, and antiviral activity. These studies also support that the honey’s biological activity is mainly dependent on its floral or geographic origin. In addition, some promising synergies between honey and antibiotics have been found, as well as some antiviral properties that require further investigation. Altogether, these studies show that honey is effectively a nutraceutical foodstuff.

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Topical Leptospermum Honey (Medihoney) in Recalcitrant Venous Leg Wounds

Cited by 9 publications

References 11 publications

Honey-Based Templates in Wound Healing and Tissue Engineering

Honey-Based Templates in Wound Healing and Tissue Engineering

Therapeutic Manuka Honey: No Longer So Alternative

Honey as a Complementary Medicine

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