Topical Lidocaine to Improve Oral Intake in Children With Painful Infectious Mouth Ulcers: A Blinded, Randomized, Placebo-Controlled Trial

Hopper, Sandy M; McCarthy, Michelle; Tancharoen, Chasari; Lee, Katherine J.; Davidson, Andrew; Babl, Franz E

doi:10.1016/j.annemergmed.2013.08.022

Cited by 40 publications

(24 citation statements)

References 21 publications

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“…A blinded, placebo‐controlled, randomised trial conducted by Hopper et al . compared 2% lidocaine versus placebo in 100 children aged between 6 months to 8 years with painful, infectious mouth ulcers.…”

Section: Efficacy Of Topical Lidocaine For Teethingmentioning

confidence: 99%

Are teething gels safe or even necessary for our children? A review of the safety, efficacy and use of topical lidocaine teething gels

Teoh

Moses

2020

J Paediatrics Child Health

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Lidocaine-based teething gels have been widely available in Australia for decades in both commercial preparations and those compounded by pharmacies. However, many case reports have highlighted potential risks and toxicity associated with lidocaine-based teething gels when used in infants and young children, including seizures, respiratory arrest and death. The Australian and New Zealand Society of Paediatric Dentistry and the American Academy of Paediatrics do not recommend topical agents for teething, and the US Food and Drug Administration does not recommend topical lidocaine for this purpose due to concerns of toxicity. Literature supporting the efficacy of lidocaine for teething is scant and difficult to interpret due to the flawed design of the trials conducted and varied formulations used. This opinion article aims to summarise the available literature showing the limited effectiveness and associated risks of topical lidocaine gels for use in teething. In light of these findings, the authors recommend that regulatory bodies such as the Australian Therapeutic Goods Administration review the efficacy and safety of this type of medicine and consider removing the indication for teething or limiting the age of use to older children.

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Section: Efficacy Of Topical Lidocaine For Teethingmentioning

confidence: 99%

Are teething gels safe or even necessary for our children? A review of the safety, efficacy and use of topical lidocaine teething gels

Teoh

Moses

2020

J Paediatrics Child Health

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“…Применение местных препаратов с лидока-ином для анальгезии полости рта (растворы, спреи, гели) не продемонстрировало эффективности при сопоставлении с плацебо [8]. Сыпь в специальной обработке не нуждается, при возникновении признаков воспаления могут быть локально применены антибактериальные и антисепти-ческие средства.…”

Section: мероприятия направленные на облегчение симптомов болезниunclassified

Should We All Save Ourselves From Coxsackie?! Or Fear Makes the Wolf Bigger Than He Is

Алачева¹,

Рыбалка²,

Куличенко³

2017

Vopr. sovr. pediatr.

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ВВЕДЕНИЕ Не важно, название какого вируса указывают после термина «эпидемия», в любом случае становится страш-но. Поставьте заморское непонятное слово «Коксаки», и большинство родителей в отчаянии начнут метаться, не зная каким «оружием» обзавестись, чтобы их дети не заболели. Вместе с тем одной из самых распростра-ненных эпидемий в летние месяцы является «эпидемия» туризма. Связанный с этим ажиотаж по поводу неко-торых «особо опасных» заболеваний порой приводит медиков в недоумение.Действительно, в летне-осенний период обычно регистрируется подъем заболеваемости энтеровирус-ными инфекциями, в т. ч. инфекциями, вызванными вирусами Коксаки [1][2][3]. Однако их повсеместное рас-пространение, аналогичная ежегодная ситуация не позволяют в настоящий момент говорить об эпидемии. Забо левание не является эндемичным.Вот и в летний период 2017 г. заголовки в средствах массовой информации о «турецкой заразе» стали пугаю-щими. Страницы журналов и Интернет-порталов пестрят фотографиями и интервью о новых случаях болезни, только усиливая всеобщую панику. Ростуризм разре-шает считать вирусы Коксаки форс-мажором. Россияне отказываются от купленных путевок или прерывают свой отдых на морских побережьях и возвращаются обратно в Россию. Знают ли они, что эти вирусы ждут их и на родине? В любом людном месте -будь то дет-ская площадка, детский сад или пляж, в России, Турции, Греции, Италии, Испании, на Кипре -повсеместно можно заразиться вирусом Коксаки. Опасность пре-увеличена в разы. Только значительное превышение уровня заболеваемости, обычно регистрируемого для данной территории, называется эпидемией. При этом никаких официальных данных об эпидемии в России на сегодняшний день нет.

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“…No difference was found in fluid intake or the need for rescue medication. 4 Amir et al compared oral acyclovir to placebo in herpetic gingivostomatitis and found that, when started within the first 72 hours, acyclovir shortened the duration of feeding and drinking difficulties. 5 This study did not address other causes of gingivostomatitis.…”

Section: Percent Agreementmentioning

confidence: 99%

“…[1][2][3] Most of those affected have a self-limited viral infection, 4 and management is usually supportive. There is some limited evidence for the use of anti-viral agents 5,6 ; however, this does not address children's acute pain needs.…”

Section: Introductionmentioning

confidence: 99%

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Analgesia for acute gingivostomatitis: a national survey of pediatric emergency physicians

MacLellan

Ali

Curtis

et al. 2016

CJEM

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Objectives: Gingivostomatitis is a common, painful pediatric presentation, and yet, few studies are available to guide management. We aimed to describe pediatric emergency physicians' current practice patterns, with respect to analgesic use in children with acute gingivostomatitis, in order to inform future studies. Methods: A national survey was conducted at all 15 national academic pediatric centres.Electronic surveys were distributed to pediatric emergency physicians using a modified Dillman protocol; non-respondents received paper surveys via post. Data were collected regarding demographic characteristics, clinical behaviour, factors that may influence practice, and future directions. Results: Response rate was 74% (150/202). Most physicians (72%) preferred the combination of acetaminophen and ibuprofen to either agent alone (ibuprofen 19%, acetaminophen 7%). The preferred second-line analgesics were oral morphine (48%, 72/150) and compounded topical formulas (42%, 64/150). The most commonly cited compounded agent was Benadryl plus Maalox (23%, 35/150). Clinical experience with a medication had the greatest influence on practice pattern, with 52% (78/149) strongly agreeing. The most commonly cited barrier to adequate analgesia was difficulty in the administration of topical or oral medication to children. Conclusions: As with many other painful conditions, the combination of acetaminophen and ibuprofen was preferred, followed by either agent alone. Oral morphine and topical compounded agents were also frequently prescribed. Regardless of patient age, physicians preferred oral morphine as a secondline agent to treat pain from severe gingivostomatitis. Future research will focus on determining which analgesic and route (oral or topical) is the most effective and best-tolerated choice. . Le facteur qui influait le plus sur la pratique était l'expérience clinique d'un médicament; en effet, 52% (78/149) des participants se sont dits « tout à fait d'accord » sur l'énoncé. Enfin, le plus grand obstacle à une analgésie suffisante était la difficulté d'administration des médicaments topiques ou oraux aux enfants. Conclusions: Comme dans bien d'autres affections douloureuses, l'association d'acétaminophène et d'ibuprofène était la formule préférée, suivie de l'utilisation seule de l'un ou l'autre de ces médicaments. Étaient souvent prescrits aussi la morphine par voie orale et les composés topiques. Indépen-damment de l'âge, les médecins préféraient la morphine par voie orale comme médicament de deuxième intention pour traiter la douleur causée par une gingivostomatite importante. Enfin, les futurs travaux de recherche devraient porter sur l'analgésique le plus efficace et la meilleure voie d'administration (orale ou topique) ainsi que sur la formule la mieux tolérée.

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Topical Lidocaine to Improve Oral Intake in Children With Painful Infectious Mouth Ulcers: A Blinded, Randomized, Placebo-Controlled Trial

Cited by 40 publications

References 21 publications

Are teething gels safe or even necessary for our children? A review of the safety, efficacy and use of topical lidocaine teething gels

Are teething gels safe or even necessary for our children? A review of the safety, efficacy and use of topical lidocaine teething gels

Should We All Save Ourselves From Coxsackie?! Or Fear Makes the Wolf Bigger Than He Is

Analgesia for acute gingivostomatitis: a national survey of pediatric emergency physicians

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